Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study, the role of psychological make-up was assessed as a risk factor in the etiology of vasospasm in variant angina (VA) using the Cornell Medical Index (CMI). Study subjects consisted of 15 patients with VA; 32 with effort angina or old myocardial infarction having no vasospasm (EA + OMI); and 34 healthy men. For a neurosis discriminative diagram, the areas I and II were judged as normal and the areas III and IV were judged compatible with a neurotic disorder. Correlation of serum lipid levels with psychological factors was attempted. 1. Among the VA patients, 46.7% belonged to the areas III and IV, as compared to 18% of the patients with EA + OMI, and 2.6% of the healthy subjects. 2. Seventy-three percent of the VA group showed anxiety states indicating a correlation with a psychological disorder. 3. A majority of the VA patients had a variety of psychological symptoms unrelated to myocardial ischemia. 4. Total cholesterol, triglycerides, LDL cholesterol, serum uric acid and the atherogenic index were all lower in the VA group than in the EA + OMI group. 5. In the EA + OMI group, triglycerides, serum uric acid and the atherogenic index were higher in the psychological group than in the non-psychological group. However, total cholesterol, LDL cholesterol and HDL cholesterol were lower in the former than in the latter group. It was concluded that an anxiety state constitutes a contributing background for developing VA and it was speculated that such an anxiety state may lead to an exaggerated secretion of stress hormones, resulting in vasospasm of the coronary arteries.
 ...
PMID:[Psychological background as a risk factor of variant angina]. 248 35

Mental illness was recorded in 17% of men and 30% of women at the first examination of a random sample of the population of north Edinburgh consisting of 215 men and 272 women aged 62-90 years. Chronic brain syndrome (CBS) was found in 6% of men and 10.7% of women. CBS severe enough to constitute clinical dementia occurred in 3% of the sample. CBS increased in prevalence with age, particularly in women. Depressive illness was found in 3.7% of men and 6.6% of women. Anxiety states were present in 7% of men and 16.5% of women. Physical health and measurements were recorded in the same random sample in respect of ischaemic heart disease, stroke, blood pressure, chronic bronchitis, respiratory function, visual acuity, audiometry, urinary incontinence and food intake. The physical findings related to CBS were poor vision, poor hearing, urinary incontinence and poor diet. Five years later 113 men and 148 women were re-examined. The annual incidence of CBS was 0.4% in men and 1.4% in women. The annual incidence of depressive illness was 0.8% in both sexes, and of anxiety neurosis was 0.3%. Mortality rates were high in subjects with CBS. All moderate/severe cases of CBS had died by the end of seven years, but 15% of the mild cases were alive after 14 years. Prevalence and incidence of CBS in the study were similar to those reported by other authors. Figures for depressive illness and anxiety neurosis tended to be higher than in other surveys.
 ...
PMID:Mental illness and physical health in older people. 633 87

We investigated the post-operative delirium in elderly patients of over 65 years of age. This investigation consisted of two studies, a prospective study and a retrospective study. In the prospective study, we evaluated the incidence of post-operative delirium and the incidence of post-operative delirium was estimated pre-operatively using State-Trait Anxiety Inventory (STAI) and Mini Mental State Examination (MMSE) in 24 patients scheduled for elective surgery under general anesthesia in the period from Nov. 1995 to Oct. 1996. In the retrospective study, we selected patients with post-operative delirium from 1600 patients who had undergone scheduled and emergency operation under general anesthesia in the same period as in the prospective study and analyzed the incidence of post-operative delirium and background of these patients. Twenty four patients in the prospective study were excluded from the retrospective study. In the prospective study, although post-operative delirium was observed in 2 cases (8.3%), no specific changes were observed in anxiety state and the ability of recognition. In the retrospective study, post-operative delirium was observed in 22 cases (1.37%). In these patients, several factors such as blood transfusion, emergency operation, dehydration, thrombosis of the superior mesenteric artery, history of ischemic heart disease, brain infarction and atrial fibrillation were thought to be major risk factors triggering post-operative delirium. In this study we could not conclude that STAI or MMSE are useful to estimate the incidence of post-operative delirium preoperatively. However, our result suggests that we should be careful about the incidence of post-operative delirium in elderly patients with pre-operative risk factors as mentioned above.
 ...
PMID:[A study of post-operative delirium in elderly patients]. 956 May 39