Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0151744 (
myocardial ischemia
)
31,282
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The UNC5 receptor family are chemorepulsive neuronal guidance receptors with additional functions outside the central nervous system. Previous studies have implicated that the
UNC5B
receptor influences the migration of leukocytes into sites of tissue inflammation. Given that this process is a critical step during the pathophysiology of
myocardial ischemia
followed by reperfusion (IR) we investigated the role of
UNC5B
during myocardial IR. In initial in-vitro experiments, the functional inhibition of
UNC5B
resulted in a significant reduction of chemotactic migration of neutrophils. In-vivo, using a model of acute
myocardial ischemia
in
UNC5B
(+/-) and wild type (WT) animals, we found a significant reduction of infarct sizes in
UNC5B
(+/-) animals. This was associated with significantly reduced levels of troponin-I and IL-6 in
UNC5B
(+/-) mice. The repression of
UNC5B
using siRNA and the functional inhibition of
UNC5B
significantly dampened the extent of myocardial IR injury. Following depletion of neutrophils, we were not able to observe any further reduction in infarct size through functional inhibition of
UNC5B
in WT and
UNC5B
(+/-) mice. In summary our studies demonstrate an important role for
UNC5B
during myocardial IR injury, and that
UNC5B
might be a potential therapeutic target to control reperfusion injury in the future.
...
PMID:The uncoordinated-5 homolog B (UNC5B) receptor increases myocardial ischemia-reperfusion injury. 2393 25
