Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The therapeutic effects of interferon in chronic hepatitis C and many of its adverse effects have been well documented. However, there are only a few reports regarding its adverse effects on the cardiovascular system. The aim of this study was to clarify the clinical features of the adverse effects of interferon on the cardiovascular system in patients with chronic hepatitis C. We monitored 295 patients with chronic active hepatitis C during 312 courses of interferon therapy and for 1 year after the end of treatment for the presence of cardiovascular adverse effects. We found 6 patients with cardiovascular adverse effects during interferon therapy and 4 more patients within 1 year after the end of therapy (10/312, 3.2%). The adverse effects of interferon on the cardiovascular system included arrhythmia (n = 4), ischemic heart disease (n = 4) and myocardial disease (n = 2). None of the clinical factors, including history of cardiovascular disease, were related to these cardiovascular adverse effects. In all instances the patient's condition improved after discontinuation of interferon and adequate therapy. The cardiovascular adverse effects of interferon occurred frequently in patients with chronic hepatitis C, even after the end of therapy and they were unpredictable. Thus, all patients undergoing interferon therapy should be monitored not only during but also after the end of treatment.
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PMID:Adverse effects of interferon on the cardiovascular system in patients with chronic hepatitis C. 905 85

Commonly seen in liquidators of the effects of the Chernobyl accident are affections of the liver (chronic hepatitis) and bile tract (chronic calculous cholecystitis) accompanied by IHD. The above patients demonstrate enhancement of the antioxidant defence in the blood with the values for free-radical peroxidation remaining unchanged. Absolute values for blood content of LTV4 in chronic active hepatitis were found out to be low, which fact suggests that such patients need to be kept under periodic oncological surveillance.
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PMID:[The antioxidant system of patients with chronic inflammatory liver diseases after exposure to ionizing radiation]. 1042 87