Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Post-IHD episode memory problems and their correlates were investigated among 157 male ischemic heart disease patients under the age of 65. Twenty-five per cent of these patients reported memory difficulties originating during the year following admission to hospital. Of the wide variety of socio-demographic factors, measures of disease severity, and lifestyle variables evaluated, only three differentiated those patients with post-IHD episode memory problems from patients with no memory difficulties. These three were: quitting smoking during the year following hospitalization, using psychotropic drugs (benzodiazepines), and having high psychosocial stress levels one year after discharge. Further analysis revealed that stress was related to memory problems primarily because stressed patients were more likely to use psychotropic drugs. It was suggested that the relationship between quitting smoking and memory problems could be explained by reference to two contradictory effects of tobacco use: a short-acting memory facilitating effect due to nicotine and a longer lasting memory impairment due to smoking-related atherosclerosis which might persist long after giving up smoking.
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PMID:Memory problems after ischemic heart disease episodes: effects of stress, benzodiazepines and smoking. 613 Nov 24

Only two cases connecting Sildenafil reception and acute memory impairment have been published. Two similar cases were observed in our clinic last year. Sildenafil is a potent inhibitor of cyclic guanosine monophosphate in the corpus cavernosum and therefore, increases the penile response to sexual stimulation and is used for erectile dysfunction. The most severe and life-threatening complications of Sildenafil are associated with combined administration with nitrates. The incidence of nonfatal myocardial infarction, stroke and death did not significantly differ between Sildenafil-treated and placebo-treated patients; therefore, Sildenafil does not appear contraindicated in subjects with ischemic heart disease (IHD). Scanty data are available regarding Sildenafil and cerebrovascular disease and there are only a few case reports regarding transient global amnesia (TGA) after Sildenafil use. Two cases of TGA are described immediately following the use of one dose of Sildenafil. The etiology of TGA is not yet completely understood but one of the hypothesizes suggests that the pathophysiology of this condition is related to intracranial vasomotor changes, especially due to venous congestion and venous ischemia of bilateral hippocampal structures. It is also well known that Sildenafil stimulates the relaxation of smooth muscle and causes vasomotor changes. Based on this report, as well as previous reports, it is suggested that a single dose of Sildenafil may stimulate TGA.
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PMID:[Two cases of transient global amnesia (TGA) following sildenafil use]. 1707 26