Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients are presented in whom ischaemic colitis followed some years after abdomino-perineal excision of the rectum for carcinoma. The first patient was a young man without evidence of arterial disease and the second patient suffered from auricular fibrillation, thought to be due to ischaemic heart disease. Ligation of the inferior mesenteric artery in the operation of abdomino-perineal excision of the rectum may reduce the blood flow through the marginal artery of Drummond rendering the remaining colon more liable to ischaemic damage. Patients who pass bright blood through a colostomy following abdomino-perineal excision of the rectum for carcinoma may have ischaemic colitis rather than a recurrence of the neoplasm.
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PMID:Ischaemic colitis and abdomino-perineal excision of the rectum. 454 Feb 95

Sumatriptan succinate, a serotonin-1 (5-hydroxytryptamine-1) receptor agonist, is an antimigraine drug that is reported to act by selectively constricting intracranial arteries. Recently, vasopressor responses that are distinct from the cranial circulation have been demonstrated to occur in the systemic, pulmonary, and coronary circulations. Cases have been published of coronary vasospasm, myocardial ischemia, and myocardial infarction occurring after sumatriptan use. We report on the development of 8 serious cases of ischemic colitis in patients with migraine treated with sumatriptan.
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PMID:Ischemic colitis and sumatriptan use. 1033 94

With the development of endovascular aneurysm repair, abdominal aortic aneurysms with short infrarenal necks (< or =10 mm, AAASN) are considered juxtarenal aneurysms. Minimally invasive treatment consists of hybrid procedures or fenestrated endografts. We present our experience with direct aortic repair for AAASN performed via a total laparoscopic approach. Data are expressed as median values with extremes. From February 2002 to December 2007, 32 patients had total laparoscopic AAASN repair. Length of the infrarenal aortic neck was 5 mm (0-10). Median age of the 29 men and three women was 70 years (range 50-84). Nine patients presented with preoperative grade 1 renal insufficiency (28.1%). The procedure was totally laparoscopic in 30 patients (93.7%). Aortic approaches included left retrorenal (n = 24) and transperitoneal left retrocolic (n = 8) exposures. Median operative and clamping times were 270 (range 215-410) and 83 (range 36-147) min, respectively. Aortic clamping was suprarenal in 14 cases (43.7%), with suprarenal clamping time of 24 min (range 9-37). Median blood loss was 850 mL (range 215-2,400). Thirty-day mortality was 3.1% (one patient died from myocardial infarction). Two patients presented with severe systemic complications (6.4%, postoperative coagulopathy with hemorrhagic syndrome, pneumopathy). Seventeen patients developed mild or moderate systemic nonlethal complications (53.1%): transient renal insufficiencies (n = 12), grade 1 ischemic colitis (n = 1), surrenal insufficiency (n = 1), myocardial ischemia (n = 1), and cardiac arythmia (n = 2). One patient was reoperated for an intestinal obstruction. Liquid diet was reintroduced after 1 day (range 1-13). Most patients were ambulatory by day 3 (range 2-17). Median lengths of stay were 48 hr (range 12-552) in the intensive care unit and 10 days (range 4-37) in the hospital. With a median follow-up of 27 months (range 1-50), 28 patients are alive, with complete recovery without graft anomalies. Three patients died, from pneumopathy (n = 1) and carcinoma (n = 2), respectively, at 29, 19, and 44 months' follow-up. Two patients presented stable juxta-renal aortic dilation <35 mm. Total laparoscopic juxtarenal AAA repair is feasible and worthwhile for patients with AAASN. Short- and midterm results match well with those of open surgery. Total laparoscopic repair in AAASN reduces the trauma of extensive surgical approaches. Based on these encouraging early results, we elected to perform laparoscopy whenever possible in good surgical risk patients with AASN.
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PMID:Total laparoscopic repair of abdominal aortic aneurysm with short proximal necks. 1913 10

Cocaine-mediated tissue injury is well established, particularly myocardial ischemia and infarction. Gastrointestinal complications including mesenteric ischemia, ischemic colitis and intestinal perforation occur less frequently. Cocaine-induced visceral arterial thrombosis is a rare finding. We report a case of a 49-year-old chronic cocaine user with superior mesenteric artery (SMA) thrombosis. The patient presented with a 24-h history of abdominal pain, nausea and vomiting. Physical examination documented tachycardia and a soft, non-rigid abdomen with voluntary guarding. Abdominal X-ray did not show any evidence of peritoneal free air or bowel obstruction. Laboratory investigations revealed elevated white blood cells and a high anion gap; a blood gas analysis was not done. Three hours after initial presentation, the patient had a cardiac arrest and died. At autopsy, the jejunum was ischemic, without obvious infarction. The SMA was occluded at its origin by significant atherosclerosis with superimposed thrombus. The myocardium had fibrosis, without acute infarction, and severe triple coronary artery atherosclerosis. Toxicological blood analysis confirmed cocaine use. This report emphasizes the need to consider chronic stimulant drug abuse in accelerated atheroma and thrombosis of visceral arteries.
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PMID:Sudden death from superior mesenteric artery thrombosis in a cocaine user. 2159 Apr 56