Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relation of carbon disulphide (CS2) exposure to risk factors for ischaemic heart disease was recently examined using data from a 1979 cross sectional study of 410 male textile workers, of whom 165 were exposed and 245 were unexposed to CS2. Average eight hour CS2 exposure concentrations ranged from 0.6 to 11.8 ppm by job title category among the exposed workers. A significant and positive linear trend in low density lipoprotein cholesterol concentration (LDLc) and diastolic blood pressure with increasing CS2 exposure was found after adjustment for potential confounders. When exposure was examined as a categorical variable (none, low, moderate, and high), the high exposure group had an adjusted mean LDLc that was 0.32 mmol/l greater than the non-exposed group (p = 0.02), and an adjusted mean diastolic blood pressure that was 3.16 mm Hg greater than the non-exposed group (p = 0.09). The effect of CS2 on diastolic blood pressure was strengthened in analyses limited to exposed workers: the high exposure group had an adjusted mean diastolic blood pressure that was 5 mm Hg greater than that of the low exposed group (p = 0.03). Triglyceride, high density lipoprotein cholesterol, and fasting glucose concentration, and systolic blood pressure were not affected by exposure. Blood lead concentration was positively associated with systolic and diastolic blood pressure. The results indicate that relatively modest exposure to CS2 may raise LDLc concentration and diastolic blood pressure and suggest mechanisms by which exposure to CS2 may influence risk of ischaemic heart disease. Also the results provide further support for the hypothesis of a possible association between blood lead concentration and blood pressure.
 ...
PMID:Effects of exposure to carbon disulphide on low density lipoprotein cholesterol concentration and diastolic blood pressure. 157 Dec 99

We examined 81 men exposed for a long time to carbon disulphide (CS2) and tested the possible electrocardiographic (ECG) changes of ischemic heart disease (I.H.D.). The subjects were examined twice in two years. In order to make the ECG evaluation more objective, the Minnesota Code was applied. Two obligatory ECG examinations and only one submaximal effort test were carried out. For comparative evaluation, the control group was examined once. We proved that, in spite of the accepted opinion concerning the atheromatous action of CS2, this compound does not cause ECG symptoms of I.H.D. in a higher percentage of exposed persons. It also does not cause any significant increase in I.H.D. symptoms in dynamic ECG observations.
 ...
PMID:Application of the Minnesota Code in evaluating electrocardiographic features of ischemic heart disease in patients exposed to carbon disulphide. 338 92

The review of published results of epidemiologic studies indicates that chronic exposure to carbon disulfide may cause functional and organic disorders of the nervous, circulatory, alimentary and endocrine systems as well as disorders of sight and hearing organs. The epidemiologic studies have been mainly carried out in populations occupationally exposed to carbon disulfide. The majority of data apply to pathologies caused by CS2 in concentrations exceeding MAC values. Some of the studies indicate that the frequency of disorders in lipid metabolism, circulatory and nervous systems as well as in the sight organ is significantly higher in workers exposed to lower concentrations of CS2 but for longer period of time. The studies of mortality show that an increased risk of death from ischaemic heart disease is a late effect of the chronic exposure to CS2. The question of teratogenic and carcinogenic effects of CS2 as well as the problem of health effects of exposure to CS2 of populations living in the vicinity of chemical fibre plants which emit CS2 into the atmosphere still remain without any clear answer.
 ...
PMID:[Epidemiologic evaluation of health effects of occupational and non-occupational exposure to carbon disulfide]. 796 5

A statistical analysis of the NIOSH (National Institute for Occupational Safety and Health) carbon disulfide (CS2) exposure database was conducted for purposes of establishing a benchmark concentration (BMC) for CS2. The analysis addressed the effects of CS2 exposure on the peripheral nervous system and on ischemic heart disease risk factors. The BMC is based on models relating response to exposure determined from statistical analysis of the continuous exposure data for individuals recorded in the NIOSH database. The results demonstrate that changes in the responses associated with increases in CS2 exposure at levels represented in the NIOSH database are relatively small after adjustment for confounders. The only response variables that had statistically significant relationships with CS2 were the peroneal nerve MCV (motor conduction velocity) and the peroneal nerve amplitude ratio. Based on these results, BMCs of 16.2 and 18.5 ppm were derived for MCV and amplitude ratio, respectively.
 ...
PMID:A benchmark concentration for carbon disulfide: analysis of the NIOSH carbon disulfide exposure database. 893 30

A mortality cohort study was carried out on 2,291 workers, including 169 women, with chronic occupational CS2 poisoning diagnosed during the years 1970-90. Information on vital status was available for 98.2% as of December 31, 1992. Mortality assessment was based on the standardized mortality ratio using the person-years method. The general population of Poland was the reference population. The number of subjects who died during the period of observation accounted for 658 men and 21 women. The analysis of mortality in male subjects showed statistically significant excess of deaths from the circulatory system diseases (SMR = 139), in this from ischaemic heart disease (SMR = 137), cerebrovascular disease (SMR = 188) and colon cancer (SMR = 233). Over a two-fold increased risk of death from diseases of the nervous system and sense organs, although statistically insignificant, was also observed. Among women a statistically significant risk of death from atherosclerosis was noted (SMR = 286). An elevated risk of death from the circulatory system diseases and from ischaemic disease (IHD) agrees with the results of some other cohort studies carried out in the viscose rayon workers. The increased mortality from malignant neoplasms is an unusual finding in cohorts of workers exposed to CS2. Our own data reported here showed a significantly increased mortality from colon cancer (9 cases). All these cases were noted in workers of the two oldest rayon plants and they require a detailed analysis. Further survey is also needed to elucidate the excess of deaths from the nervous system and sense organs diseases.
 ...
PMID:A mortality study of workers with reported chronic occupational carbon disulfide poisoning. 911 88

Recent regulatory efforts have devoted attention to carbon disulfide (CS2) exposure and its potential effects on the cardiovascular system. To investigate the association between CS2 exposure and ischemic heart disease (IHD) mortality, the analysis presented here had the following objectives: (i) to review historical CS2 exposure data in the viscose rayon industry and identify trends and (ii) to use these historical data to suggest a standard mortality ratio (SMR)-exposure relationship and a threshold level for occupational exposure to CS2, CS2 exposure data were extracted from published studies and used with the SMR versus exposure score relationship developed by Sweetnam et al. (Br. J. Ind. Med. 44, 220-227, 1987) to relate SMRs directly to exposure. Upper and lower bound exposure profiles were derived and used to identify exposure thresholds. For an IHD SMR equal to 100, the upper and lower bound exposures were 60 and 20 ppm, respectively. The analysis indicates that the risk of IHD mortality and its relationship to CS2 exposure is meaningful only for workers exposed to high level for many years. These high levels, which existed many years ago, are no longer found in the workplace. The results of this analysis suggest a safe regulatory exposure level for CS2 between 15 and 20 ppm.
 ...
PMID:A review of carbon disulfide exposure data and the association between carbon disulfide exposure and ischemic heart disease mortality. 933 88

According to literature data myocardial infarction was often the first noticeable effect of CS2 on the cardiovascular system. Therefore, a question arises whether earlier circulatory lesions are absent in CS2-exposed people, or they are present but are not detectable by the diagnostic methods used. The aim of our study has been to determine whether electrocardiological disturbances do occur in exposed people, and their association, if any, with the level of CS2 exposure. Modern diagnostic methods (resting and 24-h ECG, heart rate variability, late ventricular potential analysis, and long-term blood pressure monitoring) were used to answer this question. The examination comprised 177 male workers aged 24-66 years (44+/-12), employed under conditions of the exposure for 5-38 years (14+/-9), and 93 male workers non-exposed to CS2 aged 23-65 years (41+/-12). Results of our studies show that abnormalities in resting and/or 24-h ECG recordings occur significantly more frequently in people exposed to CS2 than in the controls. ECG abnormalities were found primarily among the workers with a long, over 20-year, period of exposure. The considerable coincidence between the questionnaire and ECG results was found (87% reported complaints were confirmed by ECG data). Therefore it seems that all CS2-exposed people reporting heart symptoms should be subjected to a detailed examination. The frequency of late ventricular potentials in CS2-exposed people was not higher than in the controls. It may indicate that the ECG disturbances observed in those people were associated with functional rather than organic changes. Results of long-term ABP monitoring did not show increased incidence of elevated blood pressure in the exposed group. As the levels of the risk factors of ischemic heart disease in the exposed and control groups were similar, it seems that exposure to CS2 was responsible for the significant changes in the circulatory system.
 ...
PMID:Cardiovascular disturbances in workers exposed to carbon disulfide. 1131 88