Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bronchial challenge with methacholine or histamine is associated with a reduction in arterial oxygen tension, which can be appreciable. In this study, oxygen saturation was monitored during methacholine challenge in subjects with and without respiratory disease, over a wide age range, in order to identify factors predicting a large fall in saturation during the challenge. Two hundred and twenty subjects aged 24-86 years were included, comprising 15 healthy adult volunteers, and 205 adults from a random sample of the local adult population taking part in a survey of bronchial responsiveness. Subjects with ischaemic heart disease or baseline FEV1 < 60% predicted were excluded. Methacholine challenge was performed by the Newcastle Dosimeter technique; oxygen saturation (SaO2) was monitored using a pulse oximeter and finger probe. Of the 220 subjects, 27% were current smokers and 39.5% were ex-smokers; 26% reported asthma or bronchitis. Mean baseline FEV1 was 100% predicted; mean baseline saturation was 97%. Mean fall in saturation was 3.2% (range 0-17.5%). Multiple regression analysis revealed that fall in saturation during methacholine challenge is related to baseline FEV1, baseline SaO2, log of total methacholine dose inhaled, and fall in FEV1 during challenge. Change in saturation was not related to subject age, smoking history, reported asthma or bronchitis, or the presence of respiratory symptoms. Methacholine challenge produces a significant fall in oxygen saturation, but this is not greater in subjects who are old or have low baseline saturation.
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PMID:Factors affecting oxygen saturation during methacholine challenge in a mixed population. 886 41

It has been widely supposed that human mortality from all causes increases with age nearly exponentially (at a constant rate) through adult ages except for very old ages, and that this exponential increase also holds fairly well for most major causes of death (CODs). However, the present analysis of death registration data for Japan, 1951-1990, reveals that the rate of age-related relative increase in mortality (the life table aging rate) changes with age significantly and systematically for many CODs. Above age 75, the mortality increase decelerates for most CODs; under age 75, it remains at a relatively stable pace for ischemic heart disease, decelerates for most major cancers, and accelerates for diseases related to a declining ability to maintain homeostasis (pneumonia, bronchitis, influenza, gastroenteritis, and heart failure). These results seem to suggest that significantly different types of senescent processes may underlie atherogenesis, oncogenesis, and immunosenescence.
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PMID:Age patterns of the life table aging rate for major causes of death in Japan, 1951-1990. 900 60

This cohort study investigated mortality patterns in Danish commercial fishermen between 1970 and 1985, compared to all economically active men. The population census in 1970 in Denmark was the source of information on individual occupation, age and economic status. Computerised linkage with the Danish Mortality Register gave information about deceased persons' date and cause of death. Standarised mortality ratio (SMR) for all causes among crew members was 1.50; 95% confidence intervals (95% CI) 1.34-1.65) highest in the age group 20-34 years (SMR = 2.09, 95% CI 1.68-2.58). The increased SMR among fishermen was primarity due to deaths by accident other than road accidents (SMR = 5.76, 95% CI = 3.09-7.46), ischemic heart disease (SMR = 1.27, 95% CI, 1.01-1.57) and causes without information (SMR = 6.44 95% CI 4.31-9.27). SMR due to bronchitis and emphysema among 35-64 years old crew members was 1.96, 95% CI 1.01-3.45. Among skippers, the SMR for all causes was 1.12, 95% CI 1.03-1.20). The study confirms earlier findings of a high mortality among fishermen, especially due to accidents, and a slightly increased risk of dying from cancer, respiratory and cardiovascular diseases.
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PMID:Mortality in Danish fishermen. 910 Oct 46

Quantum therapy was conducted in 29 patients with functional class II-III exertional angina concurrent with a first to second degree obstructive bronchitis presenting with respiratory failure. The control group was formed of 20 patients matched by illness, sex, and age, who received basic therapy. The clinical course of IHD has been shown to be improved, the concomitant pathology alleviated by the therapies applied; there was an improvement in intracardiac and regional pulmonary hemodynamics.
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PMID:[The effect of ultraviolet irradiation of the blood on lung-heart hemodynamics in patients with ischemic heart disease and concomitant chronic obstructive bronchitis]. 1042 4

Blackfoot disease was prevalent in a limited area on the southwest coast of Taiwan, where artesian well water containing arsenic (median = 0.78 ppm arsenic) had been used for many years. Previous studies of arsenic exposure in the blackfoot disease endemic area have been focused on malignant tumors. We, therefore, conducted this study to analyze mortality of all death causes in blackfoot disease endemic areas and to determine other neglected cancers or noncancer diseases related to artesian well water containing high levels of arsenic. We calculated standardized mortality ratios for cancer and noncancer diseases, by sex, during the period from 1971 to 1994 and compared them to the local reference group (i.e, Chiayi-Tainan County) and the national reference group (i.e., Taiwan population). The results revealed marked standardized mortality ratio differences for the 2 reference groups. Greater mortality was found for males and females with bladder, kidney, skin, lung, nasal-cavity, bone, liver, larynx, colon, and stomach cancers, as well as lymphoma than in the local reference population. With respect to noncancer diseases, we found greater mortality for males and females who had vascular disease, ischemic heart disease, diabetes mellitus, and bronchitis than in the local reference group. Mortalities for other diseases--including rectal cancer, cerebrovascular disease, and other diseases--were higher among cases than the local reference group. Our results indicated that the hazardous effect of arsenic is systemic. Diseases related to arsenic exposure included those reported previously by other investigators, as well as diseases reported in the present study.
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PMID:Mortality for certain diseases in areas with high levels of arsenic in drinking water. 1044 40

The study enrolled 53 patients (29 males, 24 females) with respiratory mycoplasmosis aged 15-88 years. Most of them were 59 years of age and younger. In 1/3 of the patients the diseases started with symptoms of acute respiratory viral infection, in 2/3 of them--with pulmonary affection. Pneumonia was diagnosed in 50 patients (94.3%), acute bronchitis--in 3 patients. ECG changes were registered in about half of the examinees who had no cardiac complaints. 25 of them had alterations in the end part of the ventricular ECG complex; rhythm and conduction disturbances occurred rarely. Mycoplasmosis patients suffering from ischemic heart disease (IHD) had stable ECG changes while in those free of IHD the changes were short. Myocardial necrosis foci were absent. Cardiac damage comparison in patients with respiratory mycoplasmosis and in other acute respiratory infections has found that cardiovascular system suffers less in acute mycoplasmosis. These data are useful in differential diagnosis of myocardial infections.
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PMID:[Cardio-vascular system condition in respiratory mycoplasmosis]. 1263 9

To compare the impact of therapy with dialtiazem and enapril on myocardial ischemia, this randomized study included 25 patients with chronic obstructive bronchitis and myocardial ischemia. A comparative assessment of the results of therapy showed a uniform time course of changes in the parameters of Holter monitoring and bicycle ergometry (BEM). In a group of patients receiving dialthizem, there were reduces in the number of episodes of painful and silent ischemia by 66.6 and 72.2%, respectively; the duration of myocardial ischemia and the value of the maximum ST depression decreased by 47.4%. In patients receiving enalapril, the episodes of painful and silent ischemia became fewer by 55.9 and 63.6%, respectively; the duration of ischemia and the value of the maximum ST depression decreased by 46 and 43%, respectively.
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PMID:[Drug correction of myocardial ischemia in patients with chronic obstructive bronchitis]. 1468 92

It is well known that there are social inequalities in health. Following the ecological approach, unemployment has been one of the most used indicators to study social inequalities. The aim of the present study was to investigate the relationships between indicators of extreme poverty and social unrest, along with unemployment, and mortality in Barcelona, during the years 1989 to 1993. A cross-sectional ecological study was carried out using Primary Health Care Areas (PHCAs) as the unit of analysis. The study population consisted of residents in Barcelona City. The indicators studied as dependent variables were the age-standardized mortality rates of the following causes of death: total mortality; lung cancer; bronchitis, emphysema, and asthma; cirrhosis; cerebrovascular disease; ischemic heart disease; breast cancer; traffic accidents; acquired immunodeficiency syndrome (AIDS); and drug overdose. Independent variables were male unemployment rate of the primary health care areas and indicators of extreme poverty and social conflict. A descriptive analysis, a bivariate analysis using Spearman correlation coefficients, and a multivariate analysis fitting Poisson regression models were carried out. For the main results, one group of causes of death was associated only with unemployment: bronchitis, emphysema and asthma, cerebrovascular disease, and ischemic heart disease (both men and women); lung cancer (only among men); total mortality and cirrhosis (only among women). Among men, another group of causes of death was associated with extreme poverty and/or social unrest, as well as unemployment: total mortality, cirrhosis, and drug overdose. AIDS in men was only associated with extreme poverty and social unrest. We concluded that we see different types of relationships between deprivation and mortality. Unemployment has been related to mortality because of pathologies with socially accepted risk factors (tobacco and alcohol). Causes of death with risk factors not socially accepted (illegal drug use) have been related to indicators of marginality as well as unemployment.
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PMID:Weighing social and economic determinants related to inequalities in mortality. 1527 61

To reveal latent IHD, the authors performed stress testing (veloergometry and transesophageal cardiac electric stimulation) in 63 patients with chronic obstructive dust bronchitis (CODB) and CODB complicated with bronchial asthma varying in severity. Latent IHD was diagnosed in 8% of the patients. Higher tolerance of physical exertion was seen in all groups of the patients, except for those with severe bronchial asthma--who had lower and medium tolerance. Patients with positive veloergometry test performed medium and high level of exertion.
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PMID:[Diagnosis of ischemic heart disease in patients with bronchial asthma caused by cytotoxic dust]. 1681 95

Using precipitation method, low-density (LDL) and high-density (HDL2 and HDL3) lipoproteins were isolated from blood serum of human (donors, patients with ischemic heart) diseases--IHD, with bronchial asthma--BA, with chronic obstructive bronchitis--COB), of mammals predisposed (pig, rabbit) and resistant (rat, mink, Arctic fox) to atherosclerosis, of birds (hen, pigeon), of bony fish (trout, white-fish, pike-perch, pike, bream, burbot), and of cartilaginous fish (sturgeon, white sturgeon). From each lipoprotein group, lipids were extracted, separated by thin-layer chromatography, and analyzed quantitatively by the spectrophotometric method. In phosphatidylcholine and HDL2 cholesterol esters, bound fatty acids (FA) were determined by the method of gas-liquid chromatography. The main amount of total cholesterol has been established to be concentrated in human LDL, especially in the cases of IHD, and in LDL in mammals predisposed to atherosclerosis. In mammals resistant to atherosclerosis and in fish the almost entire cholesterol was revealed in HDL. The phospholipid content in HDL was lower in patients with pathologies and in mammals predisposed to atherosclerosis, while the highest content--in fish and mammals resistant to atherosclerosis. In homoiothermal animals and in human the main FA amount in HDL was represented by the omega6-series. Acids of the omega3-series amounted to a negligible percentage, especially in IHD. On the contrary, the HDL FA composition of poikilothermal animals (fish) had a very high content of polyunsaturated FA of the omega3-series. A conclusion is made that composition of lipid components in animal lipoproteins by the example of several studied species and of human has a non-stable character and is submitted to changes. Their most pronounced modifications with a negative trend took place in human LDL and HDL in IHD.
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PMID:[Content of the main lipid components in blood serum lipoproteins of human and of various animal species]. 1767 8


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