Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum amyloid A concentrations were determined in serial serum samples of 41 patients with confirmed acute myocardial infarction (10 with acute ischaemia and two with myocarditis). A sharp increase in serum amyloid A concentration was observed early at onset of infarct; it peaked on the third day (up to 2200 fold of normal values) and declined towards normal during the following days, if no complications occurred. Different patterns were observed in patients with acute ischaemia or myocarditis. Although serum amyloid A is not a specific marker, it may, because of its high sensitivity and characteristic patterns of change, represent an additional useful biochemical variable in the diagnosis, follow up, and prognosis of acute ischaemic heart disease.
 ...
PMID:Serum amyloid A concentrations during the course of acute ischaemic heart disease. 372 15

Exercise testing is contraindicated during active pericarditis because of the possibility of myocarditis. In a patient suspected of having ischemic heart disease, a pericardial rub appeared for the first time following a maximal exercise test, during which the elevated J-points descended to baseline. In two normal volunteer subjects with early repolarization during a maximal exercise test, the elevated J-points behaved similarly. We conclude that, contrary to previous belief, electrocardiographic exercise responses cannot distinguish between pericarditis and early repolarization.
 ...
PMID:Electrocardiographic responses to maximal exercise during acute pericarditis and early repolarization. 374 68

Two cases of acute myocardial infarction occurred in association with myocarditis, which was confirmed by biopsy. The first patient suffered an anteroseptal and the second patient an inferior wall myocardial infarction shortly after an acute viral illness. In both patients, coronary angiography showed normal coronary arteries, and right ventricular endomyocardial biopsy confirmed myocarditis. Histological abnormalities attributable to ischaemic heart disease were absent. The first patient's condition became stable after immunosuppressive treatment. Myocarditis resolved spontaneously within three months in the second patient. Coronary artery spasm and myocardial involvement with a systemic disease were unlikely. Endomyocardial biopsy in patients with acute myocardial infarction and normal coronary arteries may be useful in identifying myocarditis associated with myocardial necrosis. Myocarditis in acute myocardial infarction in the absence of coronary artery obstruction has not previously been documented during life.
 ...
PMID:Myocarditis confirmed by biopsy presenting as acute myocardial infarction. 396 48

One hundred consecutive female patients with active systemic lupus erythematosus (SLE) were studied from the cardiovascular point of view by means of non invasive methods. Seventy percent of the cases presented some type of cardiovascular anomaly. Seventy four percent of the resting electrocardiograms were abnormal as well as 72% of the M mode echocardiograms and 55% of the cardiac X ray series. The most frequent observed complications were: pericarditis and or pericardial effusion (39%), arterial hypertension (22%), ischemic heart disease (16%), myocarditis (14%), congestive heart failure (10%), pulmonary hypertension (9%), valvular heart disease (9%), pleural effusion (7%) and cerebro vascular accident (3%). We analyzed each one of these complications and found of special interest the high incidence of ischemic heart disease which is more frequent than has been hitherto reported. Ischemic heart disease was observed in two types of patients: a) Those with long term steroid therapy. In these, the mechanism seems to be an atherosclerotic disease probably induced by the chronic use of steroids. The management of these cases do not differ from other types of coronary heart disease due to atherosclerosis. b) Those with frank episodes of vasculitis in whom the basic mechanism is an inflammatory process of the coronary arteries and its treatment is fundamentally that of the vasculitis. We consider necessary to study routinely all patients with SLE through non invasive cardiological methods.
 ...
PMID:Cardiovascular manifestations in systemic lupus erythematosus. Prospective study of 100 patients. 402 48

Focal electrocardiographic abnormalities have been noted in three young adults who developed acute diabetes after an illness bearing the hallmarks of a viral infection. The persistent S-T and T wave changes were inexplicable in terms of acute electrolyte imbalance or ischaemic heart disease and were ascribed to viral myocarditis. The significance of this is discussed.
 ...
PMID:Three cases of acute ketotic diabetes mellitus with myocarditis: a common viral origin? 421 2

The chest X-ray films of 251 patients with cardiovascular lesions, collected in the major hospitals of Papua New Guinea, were reviewed. Cor pulmonale (18%) and rheumatic heart disease (16%) were the predominant cardiac disorders, and cor pulmonale was the most common cause of cardiac failure (58%). Cardiomegaly or cardiac failure of unknown cause, possibly due to cardiomyopathy or myocarditis, made up 9% of the group and may be more important than has been thought previously. Aortic-arch calcification typical of atheroma was present in 21% of the patients, and is thus quite common, even though ischaemic heart disease remains very rare (1%). More than half of the patients with aortic atheroma had chronic lung disease, and though this could be explained by the coincidental frequency of both conditions, the possibility of an association or link in pathogenesis between them deserves further consideration. Anaemia was a common cause of cardiac enlargement (14%), and sometimes led to cardiac failure. Only 16 patients had hypertension (essential in 10 patients and renal in six), and this may indicate a change from the previously reported predominance of renal hypertension in Papua New Guinea towards a more equal incidence of the two conditions. Aneurysms of unknown cause were encountered in three fairly young patients. They had some resemblance to the aneurysms in arteritis of obscure origin described in Africa. There were also two dissecting aneurysms and one syphilitic aneurysm of the aorta. Congenital lesions (8%), pericarditis due to various causes (including tuberculosis), bacterial endocarditis (in four patients with rheumatic heart disease), and miscellaneous conditions made up the remainder of the series.
 ...
PMID:Cardiovascular disease in Papua New Guinea. 644 34

Oxygen free radicals and their metabolites generated from activated neutrophils have been implicated in mediating the cardiovascular dysfunction of such diverse etiologies as myocardial ischemia and reperfusion injury, Gram negative sepsis, myocarditis and acute cardiac allograft rejection, but a direct demonstration of neutrophil derived oxygen free radical mediation of cardiovascular dysfunction has not been accomplished. In this study, we have demonstrated that activation of the canine neutrophil system, in vivo, results in the generation of oxygen free radicals that are capable of disrupting cardiovascular function producing a significant decrease in mean arterial pressure and cardiac index without any significant effect on the conduction system of the myocardium. Neutrophil depletion or pretreatment with superoxide dismutase and catalase inhibited the effects of activated neutrophils. This study provides evidence that neutrophil-derived reduced oxygen intermediates are able to induce severe cardiovascular dysfunction.
 ...
PMID:Neutrophil-derived, oxygen free radical-mediated cardiovascular dysfunction. 652 Aug 76

Four hundred and eight sudden cardiac deaths are reviewed from epidemiological and pathological viewpoints. All cases were investigated by Otago coroners between 1971 and 1979. Necropsies were performed personally by the author, these representing over 80% of such examinations in the specified period. Fifty-four point nine percent of the deaths occurred at home, 9.1% in public places, 9.1% in hospitals and 3.7% in sports grounds. The majority (88.7%) occurred between the ages 41-80, the peak being 51-70 (61.3%). Seventy-one point three percent were male. There was an associated history of physical exertion in 19.4% but relevant information was unobtainable in 46.6%. Judging from gastric contents, food had been consumed recently in 64.9%. There was a relevant medical history in 44.6%. In 40.9% significant symptoms were recorded prior to the deaths. At necropsy 84.8% were attributed to ischaemic heart disease, 7.1% to myocarditis, 4.7% to cardiomyopathy and 3.4% to valvular disease.
 ...
PMID:Sudden cardiac death in Otago: a review of 408 cases. 657 61

Arrhythmias may be controlled in most patients with recurrent supraventricular tachycardia or atrial fibrillation with small to moderate maintenance doses of amiodarone (100 to 400 mg/day). Moderate doses (400 mg/day) are also highly effective in suppressing "warning" ventricular arrhythmias in patients with chronic ischemic heart disease, particularly if the goal of treatment is to eliminate ventricular couplets, runs of ventricular tachycardia (VT), and the "R on T" phenomenon. Treatment and prevention of sustained recurrent VT and the malignant arrhythmias of chagasic myocarditis require, however, doses of about 800 mg/day, which may be higher than those needed for ischemic heart disease complicated by VT and ventricular fibrillation. Clinical studies suggest an elimination half-life for amiodarone of about 30 days (range 15 to 100 days). Thus there is a pretherapeutic latency period that varies according to the type of arrhythmia and the doses employed. The maximal effects (as well as the most significant adverse effects) are not attained before 90 to 150 days of treatment, and the antiarrhythmic protection may persist for varying intervals, up to 150 days or more, after the drug has been discontinued. Side effects are not negligible but are generally dose dependent. Despite these side effects, many patients have been treated by us with amiodarone for as long as 5 to 8 years--and for up to 10 years in some cases. Amiodarone appears to be one of the most promising drugs for the possible prevention of ventricular fibrillation and sudden death.
 ...
PMID:Ten years of experience with amiodarone. 661 43

Though habitual, but not excessive use of laxatives can be observed frequently, no accompanying clinical symptoms have yet been described. The frequent observation of tetany and edema is striking, there is a marked decrease of potassium clearance and an incipient impairment of creatinine clearance. A secondary hyperaldosteronism can be ruled out. The electrocardiograms of 9 patients show signs of mild hypokalemia, which in 2 patients were first misinterpreted as myocardial ischemia and in one patient taken as indication of myocarditis. Oral administration of potassium normalizes the electrocardiograms.
 ...
PMID:[Consequence of habitual use of laxatives (author's transl)]. 678 58


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>