Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

29 cases of sudden heart death (SHD) which occurred in hospital after heart surgery within 1989-1998 are reported. More than 50% were SHD after aortocoronary shunting, it occurred in stenosing atherosclerosis of more than 3 arteries. An important role in tanatogenesis belongs to ischemic heart disease (IHD) with complications (chronic aneurysm of the left ventricle, postinfarction failure of the mitral valve) and combination of IHD with aortal heart deficiency which is followed by pronounced hypertrophy of the left ventricle which is an important factor of SHD risk. Interventricular defects and Fallot's tetrad are most frequent among heart malformations with SHD after heart surgery. Cardiomegaly, myocardial fibrosis, dilatation of the heart cavities, fibroelastosis of ventricular endocardium, anomalous chordal arrangement in the left ventricle, right ventricular lipomatosis are main factors of SHD of the arrhythmogenic type after heart surgery. Introduction of the new notion "sudden heart death at the hospital stage after heart surgery" is suggested.
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PMID:[Sudden arythmogenic death in hospitals after heart surgery]. 1139 89

Epidemiological studies on workers employed at the Mayak plutonium enrichment plant have demonstrated an association between external gamma ray exposure and an elevated risk of ischemic heart disease (IHD). In a previous study using fresh-frozen post mortem samples of the cardiac left ventricle of Mayak workers and non-irradiated controls, we observed radiation-induced alterations in the heart proteome, mainly downregulation of mitochondrial and structural proteins. As the control group available at that time was younger than the irradiated group, we could not exclude age as a confounding factor. To address this issue, we have now expanded our study to investigate additional samples using archival formalin-fixed paraffin-embedded (FFPE) tissue. Importantly, the control group studied here is older than the occupationally exposed (>500 mGy) group. Label-free quantitative proteomics analysis showed that proteins involved in the lipid metabolism, sirtuin signaling, mitochondrial function, cytoskeletal organization, and antioxidant defense were the most affected. A histopathological analysis elucidated large foci of fibrotic tissue, myocardial lipomatosis and lymphocytic infiltrations in the irradiated samples. These data highlight the suitability of FFPE material for proteomics analysis. The study confirms the previous results emphasizing the role of adverse metabolic changes in the radiation-associated IHD. Most importantly, it excludes age at the time of death as a confounding factor.
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PMID:Chronic Occupational Exposure to Ionizing Radiation Induces Alterations in the Structure and Metabolism of the Heart: A Proteomic Analysis of Human Formalin-Fixed Paraffin-Embedded (FFPE) Cardiac Tissue. 3295 60