Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although the safety and efficacy of esophagogastroduodenoscopy (EGD) after myocardial infarction (MI) are fairly well characterized, the safety of enteroscopy after recent MI is unstudied and unknown. Enteroscopy could potentially be particularly valuable to evaluate recurrent obscure gastrointestinal (GI) bleeding after MI because ongoing GI bleeding could induce recurrent myocardial ischemia. The safety of push enteroscopy is analyzed in a study of 4 cases among 8900 patients with acute MIs during an 8-year period at a tertiary care medical center. Four patients underwent enteroscopy at 1, 4, 28, and 45 days after MI, of whom three were prospectively monitored for enteroscopic complications. The patients were 82, 63, 72, and 76 years old. Three were male. The mean serum creatinine kinase level was 601 +/- 162 U/L, with an MB fraction of 15.9 +/- 13.2%. All MIs were subendocardial. Enteroscopy indications included recurrent fecal occult blood and anemia requiring multiple packed erythrocyte transfusions with no significant lesions identified by EGD and colonoscopy in two patients, maroon stools with no lesions identified by colonoscopy and only anastomotic erosions identified by EGD in one patient status post-Billroth I gastrectomy, and dark red blood per rectum in one patient with prior aortic graft revision for an aortoenteric fistula after failure to visualize the distal duodenum by EGD. The patients received a mean of 4.0 +/- 1.3 U of packed erythrocytes before enteroscopy. At enteroscopy the mean hematocrit was 32.7 +/- 1.6. The patients received a mean of 18.8 +/- 12.5 mg of meperidine and 2.6 +/- 2.2 mg of midazolam during enteroscopy. Enteroscopy was uniformly uncomplicated. Vital signs and arterial oxygen saturation remained stable during and following enteroscopy. Enteroscopy revealed no new lesions in two patients and distal duodenitis in one patient and ruled out an aortoenteric fistual in one patient at high risk for this lesion. These four cases suggest that enteroscopy is not absolutely contraindicated and might be considered after recent MI for strong indications in relatively clinically stable patients.
 ...
PMID:Safety of push enteroscopy after recent myocardial infarction. 1513 7

In recognition of Korea's rising burden of non-communicable diseases (NCDs), we investigated the nation's NCD status and extracted detailed information from the 2012 Korean Burden of Disease study. Consistent with that study, we used disability-adjusted life year (DALY) as a metric. Using national data sources and disability weights specific to the Korean population, we analyzed 116 disaggregated NCDs from the study's four-level disease and injury hierarchy for both sexes and nine age groups. Per 100,000 population, 21,019 DALYs were lost to 116 NCDs. Of those, 13.97% were due to premature death (death prior to the standard life expectancy for a subject's age) and 86.03% to non-fatal health outcomes. Based on traditional statistics, the main causes of health loss were mortality of neoplasms; cardiovascular and circulatory diseases; diabetes, urogenital, blood, and endocrine diseases; and chronic respiratory diseases. When combined with analyses of premature death and non-fatal outcomes, however, a substantially different view emerged: the main causes of health loss were diabetes mellitus, low back pain, chronic obstructive pulmonary disease, ischemic heart disease, ischemic stroke, cirrhosis of the liver, osteoarthritis, asthma, gastritis and duodenitis, and periodontal disease (in that order), collectively causing 49.20% of DALYs. Thus, burden of disease data using DALYs rather than traditional statistics brings a new perspective to characterization of the population's health that provides practical information useful for developing and targeting national NCD control programs to better meet national needs.
 ...
PMID:The Non-Communicable Disease Burden in Korea: Findings from the 2012 Korean Burden of Disease Study. 2777 53

There is a significant data about overlap of functional dyspepsia (FD) and irritable bowel syndrome (IBS), however mostly the data is based on the previous diagnostic criteria and do not include other pathologies. In the previous researches there were no differential statistical analysis performed for different types of FD - postprandial distress syndrome (PDS) and epigastric pain syndrome (EBS). Aim of the study - to assess potential risk factors and the prevalence of comorbid conditions associated with FD and to compare their frequency with the same in the group with no dyspeptic complaints and in patients with different types of FD - PDS and EPS. This study was conducted as a retrospective database analysis of the patients with newly set diagnosis of FD and control group. For all the cases the information on demographic (working status, family status) and lifestyle characteristics (body mass index, smoking status, and alcohol consumption), and comorbidities were collected from the medical files. We statistically analyzed the presence of risk factors, comorbidity and its frequency in the patients with FD and compared the results with control group and in the groups with different types of FD according to the generally accepted standards. This study included 158 patients with PDS, 87 patients with EBS, and 90 volunteers with no dyspeptic complaints. Smoking, alcohol consumption, and family status were not associated with the risk of FD. The presence of sleep disorders and being unemployed increased the risk of FD. The comparison of the results of the patients with different types of FD demonstrated that there were no statistical difference in risk factors for the PDS and EPS. Gastroesophageal reflux disease (GERD), IBS, chronic gastritis and / or duodenitis, anxiety, and depression occur more frequently in the group of patients with FD. No association between autoimmune thyroiditis (AIT), arterial hypertension and ischemic heart disease (IHD) was evaluated. There was no statistical difference for the frequency of GERD, chronic gastritis and / or duodenitis, anxiety, AIT, arterial hypertension, and IHD in the patients with different types of FD. However, it was evaluated that IBS and depression occur more frequently in the group of patients with PDS, than in the patients with EPS.
 ...
PMID:RISK FACTORS AND COMORBIDITY IN DIFFERENT TYPES OF FUNCTIONAL DYSPEPSIA: RETROSPECTIVE COHORT ANALYSIS. 3327 May 86