Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0151744 (myocardial ischemia)
 31,282 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The specific features of ischemic and arrhythmic manifestations and their relationship to the autonomic nervous system studied by analysis heart rhythm variability (CRV) were investigated in 87 patients with prior large myocardial infarction by using Holter monitoring. Spectral analysis of CRV revealed that in painful ischemia (PI) the total frequency (TF) of waves significantly decreased by 22%. In turn, episodes of silent ischemia (SI) were associated with a substantial (42%) increase in VLF-range power with a simultaneous significant reduction in the HF region of the spectrum by 53.8%. At the same time, the PI and SI groups greatly differed in the severity of complicated ventricular arrhythmias registered in 66.7 and 24.4% cases, respectively (p < 0.01). Thus, differences have been found in the episodes of myocardial ischemia: the pain equivalents are characterized by a higher risk for arrhythmia and SI is likely to be associated with the imbalance of ANS and with higher neurohumoral activity.
 ...
PMID:[Autonomic balance and some daily ECG monitoring parameters in patients with prior myocardial infarction]. 1466 68

The purpose of the case study was to investigate the effect from the bolus dosing of midazolam and ketamine on the autonomic hemostasis in patients with ischemic heart disease (IHD) with the prevalence of the activity of sympathetic or parasympathetic parts in the autonomic nervous system. The IHD patients (n = 75) were examined, after scheduled preoperative therapy, active orthostatic tests and tests of cardiac rate variability (CRV to determinine a type of autonomic response. After orthostatic-test results were analyzed, patients with sympathicotonic (n = 15) and vagotonic (n = 15) types of vegetative response were selected. After midazolam at 0.08-0.12 mg/kg and ketamine at 0.5-1.3 mg/kg were administered, CRV was analyzed in the operating theater.
 ...
PMID:[Effect of intravenous hypnotics on autonomic response in patients with ischemic heart disease]. 1557 15