Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0149958 (complex partial seizures)
 2,563 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Three consecutive studies were done with 12 wheat samples (4 per study), each of different variety (6 containing the 1B/1R rye translocation) to examine the effects of wheat variety, presence of 1B/1R and interactions with xylanase addition (Avizyme 1310). The wheat varieties covered a wide range of in vitro viscosity (6.3 to 19.8 cps). In each study 64 male, Ross broilers were individually caged and given the diets ad libitum from d 7 to 28. Bird performance, viscosity of ileal contents and diet metabolisability (AME) were measured. 2. The diets contained (g/kg): wheat 790, casein 134, dicalcium phosphate 21.4, potassium bicarbonate 10.8, sodium bicarbonate 7.5, soya oil 10, arginine 5, minerals etc. 21.3. 3. Within each study there were large differences in dry matter (DM) intake between varieties but the variety effect was significant (P<0.01) only in study 2. Liveweight gain (LWG) differences mirrored DM intake, being significant (P<0.01) in study 2. Mean gain:food was unaffected by variety in any study. 4. Calculated wheat AME (MJ/kg DM) ranged from 13.4 to 14.4 in study 2 (P<0.05), the values for studies 1 and 3 lying within this range. 5. Across all 3 studies, in vivo viscosity (proximal ileum) ranged from 5.0 to 37.6 in the absence of enzyme and from 3.9 to 12.1 with enzyme addition; in studies 1 and 2 variety differences were significant (P<0.05). 6. Enzyme addition had no effect on DM intake or LWG but gain:food tended to be improved (NS), metabolisability of energy (ME:GE) was increased (P<0.01) by 2.2% and calculated wheat AME by 4% while in vivo viscosity was reduced (P<0.001). 7. There were no significant differences in DM intake, LWG, gain:food, ME:GE or calculated wheat AME concentration associated with the presence of the 1B/1R translocation and no interactions between enzyme and 1B/1R. 8. There were poor relationships between either gain:food or wheat AME concentration and in vitro or in vivo viscosity. There was no significant relationship between AME concentration and either specific weight or thousand grain weight. 9. It was concluded that (a) variety differences tended to be small (b) there was no negative impact of the 1B/1R rye translocation with the diet formulation used (c) in vitro viscosity failed to predict satisfactorily any aspect of performance with the high wheat/low fat diet formulation used.
 ...
PMID:Effects of variety, the 1B/1R translocation and xylanase supplementation on nutritive value of wheat for broilers. 1181 16

1. This study used 4 wheat cultivars (Brigadier, Chaucer, Consort, Reaper) from three locations (Crossnacreevy, C; Downpatrick, D; Limavady, L), which had given rise to differences in wheat specific weight (SW), to examine the relationships between apparent metabolisable energy (AME) concentration, broiler performance and wheat SW. 2. The diets contained (g/kg): wheat 744, casein 142, blended vegetable fat 50, dicalcium phosphate 22, potassium bicarbonate 10.8, sodium bicarbonate 7.5, arginine 5, methionine 2, binder 8, trace minerals/vitamins 7.2, titanium dioxide 1.5. The diets were heat-treated (80 degrees C for 2 min) prior to pelleting (3 mm die). 3. SW ranged from 63 to 77 kg/hectolitre (hl), averaging 66, 69 and 76 kg/hl at D, C and L, respectively. In vitro viscosity of the wheat samples ranged from 5.2 to 17.5 cps and thousand grain weight (TGW) from 33.4 to 47.3 g. Mean TGW was similar at C and D (38.7, 37.0 g) but higher at L (43.1 g). In vitro viscosity was similar at C and L (11.2, 10.2 cps) but somewhat higher at D (14.4 cps). Crude protein (6.25 N) ranged from 116 to 147 g/kg and tended to be higher at D. Starch, which ranged from 612 to 656 g/kg, was least at D (617 g/kg) and greatest at L (641 g/kg). 4. Crude protein, crude fibre and total non-starch polysaccharide (NSP) were negatively correlated with SW, the R2 being respectively 0.38 (P<0.05), 0.16 (NS) and 0.45 (P<0.05). TGW and starch concentration were positively correlated with SW (R2=0.70, 0.44, respectively). There was a weak (NS) negative relationship (R2=0.19) between in vitro viscosity and SW. For both TGW and in vitro viscosity, correlations improved when variety was taken into account (R2=0.95, 0.92, respectively). 5. There were no significant effects of variety on dry matter (DM) intake or live weight gain (LWG). Gain: food was significantly higher (P<0.05) for Consort than for the other three varieties and the metabolisable energy ratio (ME:GE) just failed to attain significance (P=0.062). Calculated wheat AME (MJ/kg DM) was significantly (P<0.05) higher for Consort than for the other three wheats. There was a good correlation (R2=0.49) for the total data set between gain:food and ME:GE. In vivo viscosity varied from 13.6 to 28.6 cps for individual treatments and was significantly affected by variety (P<0001). 6. Although there were no significant differences in DM intake or LWG due to site the values for L (SW 76) were 6 and 5% lower, respectively, than for D (SW 66). Gain:food was lower (P<0.05) for C (SW 69) than for D. ME:GE, wheat AME and ME:gain were not significantly different between sites. 7. There was a weak (R2=0.18) positive relationship between ME:GE and SW corresponding to a 2.5% increase in energy value for a 10 kg/hl increase in SW and no relationship between gain:food and SW. When variety was taken into the regression the slope was similar but R2 increased to 0.82. 8. ME:GE and wheat AME concentration were negatively correlated with wheat in vitro viscosity (R2=0.64, 0.55, respectively). 9. It was concluded that in vitro viscosity appears to provide a better basis than SW for prediction of the nutritive value of wheats of unknown variety. If the variety is known then SW could be used to predict energy value. However, the effect of quite a large change in SW (10 kg/hl) was relatively small.
 ...
PMID:Effects of wheat variety and specific weight on dietary apparent metabolisable energy concentration and performance of broiler chicks. 1204 90

1. A study of the relationship between specific weight (SW) and nutritive value of wheat in diets offered to broilers up to 4 weeks of age was carried out using 10 varieties of wheat grown at three different locations; this gave rise to a range of specific weights from 59 to 76 kg/hl. 2. Because five varieties contained the 1B1R translocation and 5 did not, this allowed the effects of 1B1R on the performance of birds given high concentrations of dietary wheat to be further investigated. 3. The diets, which contained wheat at 744 g/kg with casein (142 g/kg) as the sole protein supplement, were heat-treated and pelleted. They were fed ad libitum to male, Ross broiler chicks from 7 to 28 d, in individual cages in a controlled environment room. 4. A 7 d excreta collection was made from 14 to 21 d for determination of apparent metabolisable energy (AME) content and wheat AME was calculated from the diet values. A separate determination of true metabolisable energy (TME) was undertaken using the method of McNab and Blair (British Poultry Science, 29: 697-707, 1988). 5. Wheat samples were analysed for proximate constituents, starch, total and soluble non-starch polysaccharides (NSP), amino acid content and gross energy and specific weight, thousand grain weight and in vitro viscosity were recorded. They were also subjected to near infrared reflectance spectroscopy (NIRS) with a view to establishing relationships with chemical constituents and performance parameters. 6. At 28 d the birds were humanely killed and in vivo viscosity was determined on the jejunal digesta supernatant. 7. There was quite a narrow range of crude protein content (N x 5.83) across the 30 wheat samples, the means for the three locations (Crossnacreevy, Downpatrick and Limavady, respectively) being 112, 121 and 122 g/kg. Starch contents of individual samples ranged from 604 to 679 g/kg, total NSP from 92.1 to 122.6 g/kg, soluble NSP from 17.6 to 32.6 g/kg and in vitro viscosity from 10.6 to 26.3 cps. 8. There were no significant varietal effects for dry matter intake (DMI), live weight gain (LWG) or gain:feed ratio. Apparent metabolisability of energy (ME:GE) for the diets ranged from 0.738 (Hussar) to 0.778 (Harrier) the effect being significant (P < 0.05) and there was a significant (P < 0.001) relationship (r(2) = 0.46) between ME:GE and gain:feed ratios. Calculated wheat AME for individual varieties ranged from 14.1 to 15.0 MJ/kg DM (P > 0.05). TME values ranged from 16.3 to 16.6 MJ/kg DM (NS). 9. In vivo viscosity ranged from 12.3 (Ritmo) to 23.7 cps (Hussar), the varietal effects being significant (P < 0.001). Viscosity was significantly higher for the 1B1R varieties than for the non-1B1R (22.7 vs 16.3 cps) but there were no significant effects on mean DM intake, LWG, gain:feed, ME:GE, calculated wheat AME, ME:gain (MJ AME per kg gain) or TME. 10. Wheat AME was negatively correlated (P < 0.05) with total NSP (slope -0.035) but was significantly affected by variety, constants ranging from 16.74 to 17.79. For wheat TME there were significant variety*total NSP interactions with slopes ranging from 0.29 to -0.07. There was no significant relationship between wheat AME and soluble NSP and there were significant variety*soluble NSP interactions for TME with slopes ranging from 0.09 to -0.14. 11. Despite the relatively wide range of in vitro viscosity there was no significant correlation of either calculated wheat AME or wheat TME with in vitro viscosity. For TME there were significant variety*viscosity interactions with slopes ranging from 0.21 to -0.13 (P < 0.001). There was also no significant correlation between soluble NSP and in vivo viscosity. 12. AME values for the NIRS calibration set varied from 13.7 to 15.6 MJ/kg and averaged 14.6 MJ/kg, whereas for the validation set, the values ranged from 14.0 to 16.1 MJ/kg with the mean value being 14.7 MJ/kg. The best correlation coefficient (r(2)) of 0.90 was obtained when the calibration sample set was subjected to SMLR using the second-order derivatised data. However, moving to validation, the outcome was extremely poor with 1-VR values being 0.12 and 0.09, respectively, for the external validation and an internal validation subset. 13. In summary, none of the production characteristics showed a good correlation with specific weight. Using the linear estimates for wheat AME and TME the effect of a 10 kg/hl change in SW equates to a 3 or 1.4% change, respectively. The estimate for AME is likely to be a worst-case value due to the high inclusion level of wheat. The range of calculated wheat AME (approximately 1 MJ) across the 30 wheat samples is similar to that seen in previous studies for wheat grown in Northern Ireland and much lower than in some other studies. 14. None of the other parameters examined gave any better relationship with nutritive value (assessed as AME or TME) than SW. This is a disappointing outcome, particularly in view of some previous studies which suggested that in vitro viscosity provides a good prediction of nutritive value.
 ...
PMID:Lack of relationship between either specific weight or presence of the 1B1R gene and nutritive value of wheat in broiler diets. 1870 93