Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149958 (complex partial seizures)
 2,563 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mice treated with barbital (0.1% in the drinking water) during 15 days showed a 63% increased endoplasmic reticulum mass. The carbon tetrachloride-stimulated chemiluminescence of the in situ liver was 51% increased after barbital treatment. Hydroperoxide-stimulated chemiluminescence of liver homogenates and microsomal suspensions were increased by 140 and 92%, respectively, in the barbital-treated mice. Spontaneous liver chemiluminescence (109 cps/cm2) was found unchanged after barbital treatment. Superoxide dismutase, catalase and glutathione peroxidase activities were 109, 61 and 103%, respectively, increased after barbital treatment. The results are consistent with a primary role of cytochrome P 450 in the biotransformation of CCl4, which initiates a radical chain reaction leading to the production of powerful oxidizing species. Apparently, superoxide dismutase, catalase and glutathione peroxidase are synthetized in a coincident manner with respect to cytochrome P 450.
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PMID:Increased carbon tetrachloride-stimulated chemiluminescence in the in situ liver of barbital-treated mice. 624 Sep 13

Rats fed ethanol (1.74 +/- 0.12 g/day/100 g body wt for 12 weeks) showed a 45% increased microsomal production of O-2 (2.23 +/- 0.14 nmol/min/mg protein) and a 28% increased content of endoplasmic reticulum protein (26.8 +/- 1.4 mg/g liver). This could lead, at substrate saturation, to a 86% increased cytosolic production of O-2 which is not compensated by cytosolic superoxide dismutase levels that remain normal. It is claimed that this unbalance between O-2 production and superoxide dismutase leads to a peroxidative stress in agreement with the 54% increased spontaneous liver chemiluminescence (37 +/- 2 cps/cm2) measured in the ethanol-treated rats. Hydroperoxide-induced chemiluminescence was 57, 43, and 28% higher, respectively, in homogenates, mitochondria, and microsomes isolated from ethanol-treated rats as compared with controls. Vitamins E and A were more effective inhibitors of the hydroperoxide-stimulated chemiluminescence in the liver homogenates from ethanol-treated rats as compared with the effect on the homogenates from control animals. The results are consistent with a peroxidative stress in chronic alcoholism leading to increased lipoperoxidation and decreased levels of antioxidants.
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PMID:Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats. 632 Jul 28