Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149958 (complex partial seizures)
 2,563 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 16-year-old boy who had been found at the age of 9 years to have complex partial seizures was referred to our department by a psychiatrist for evaluation for surgical treatment of epilepsy, in 1994. A diagnosis of multiple cerebral infarction accompanied with arachnoid cyst was made when he was 11 years old, in 1988, by computed tomography (CT) and magnetic resonance imaging (MRI) findings. Results of a neurological examination on admission revealed marked mental and speech retardation. MRI and CT studies demonstrated an enlarged Sylvian fissure and a mass lesion in the left frontal lobe which was enlarged, compared to the findings of MRI in 1988. A left fronto-temporal craniotomy with excision of the frontal lesion was performed. Histological examination revealed cortical dysplasia, multi-nodular pattern, and glioneuronal components, whose findings coincide with criteria for diagnosing dysembryoplastic neuroepithelial tumors. MIB1 antibody immunostaining study revealed no positivity, but immunostaining study for PCNA (proliferation of cell nuclear antigen) revealed from 0 to 6.5% positivity in each nodule. PCNA high positivity was observed in the nodules which were composed of packed oligodendrocyte-like cells. Enlargement in the size of the lesion in our case suggests increased cell proliferation activity during a 6-year period.
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PMID:[An enlarging dysembryoplastic neuroepithelial tumor during a 6-year period: a case report]. 988 50

Mesial temporal lobe epilepsy (MTLE) is a neurological disorder associated with spontaneous recurrent complex partial seizures and hippocampal sclerosis. Although increased hippocampal neurogenesis has been reported in animal models of MTLE, increased neurogenesis has not been reported in the hippocampus of adult human MTLE cases. Here we showed that cells expressing doublecortin (Dcx), a microtubule-associated protein expressed in migrating neuroblasts, were present in the hippocampus and temporal cortex of the normal and MTLE adult human brain. In particular, increased numbers of Dcx-positive cells were observed in the epileptic compared with the normal temporal cortex. Importantly, 56% of Dcx-expressing cells in the epileptic temporal cortex coexpressed both the proliferative cell marker, proliferating cell nuclear antigen and early neuronal marker, TuJ1, suggesting that they may be newly generated neurons. A subpopulation of Dcx-positive cells in the epileptic temporal cortex also coexpressed the mature neuronal marker, NeuN, suggesting that epilepsy may promote the generation of new neurons in the temporal cortex. This study has identified, for the first time, a novel population of Dcx-positive cells in the adult human temporal cortex that can be upregulated by epilepsy and thus, raises the possibility that these cells may have functional significance in the pathophysiology of epilepsy.
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PMID:Doublecortin expression in the normal and epileptic adult human brain. 1904 68