Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149958 (complex partial seizures)
 2,563 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical and electroencephalographical investigations were made on the 234 patients with neuropsychiatric disorders, showing small sharp spikes (sss) on EEG. Incidence of sss was significantly higher in patients with epilepsy (8.6%) than in the non-epileptic cases (2.5%), especially in early age groups (11-35 years). Some differences in clinical features and in characteristics of sss were found between the epileptic patients and the non-epileptic patients; namely, 1) In majority of the subjects (97%), sss were observed exclusively in stage 1 and 2 of sleep, however, 8 epileptic patients exhibited sss in deep sleep (stage 3) or in awake state, as well as in light sleep. 2) In the non-epileptic group, females (3.4%) showed significantly higher incidence of sss than males (1.7%), while there was no sex difference in the epileptic group. 3) Of the non-epileptic patients, 45% had autonomic symptoms, such as headache, dizziness, tinnitus, nausea and vomiting, while there was no significant correlation between particular neuropsychiatric diagnosis and the EEG pattern. Among the non-epileptics, 72% showed normal EEG except for sss and in 89% sss appeared bilaterally but commonly bilaterally independently. 4) As to relation of sss to seizure types of epilepsy, complex partial seizures showed significantly higher incidence of sss (25.2%) than simple partial seizures (7.5%) and generalized tonic-clonic seizures (6.5%). In the patients with epilepsy, sss were often observed unilaterally predominantly (49%), especially in the patients with complex partial seizure (57%). In complex partial seizure, unilateral sss coincided with laterality of anterior-temporal seizure discharges in 68%. According to the results, the authors suggested that sss has some electroencephalographical significance, probably on mechanisms relating to epileptogenic dysfunction, particularly that of complex partial seizures.
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PMID:[Clinico-electroencephalographical significance of small sharp spikes]. 686 May

The Erbium:YAG-laser is a good tool for microresection of bone and soft tissue from the ear drum, to the ossicles and extending to the footplate. The mechanism of ablation is based on the fact that the emission of infrared light is of the same wavelength at which water has its peak of optimal light absorption. 14% of bone is water, just sufficient force for ablation. At 50 mJ impulses the temperature in the centre stays below the coagulation point. 500 impulses of 50 mJoule definitely remain below the acoustic risk. In 44 guinea pigs 500 x 50 mJ caused a temporal threshold shift of maximal 38 dB at 2000 cps which recovered after 90-135 min. In 60 tympanoplasties neither tinnitus nor audiological side effects of the laser application were measured. The ear drum is perforated by 1 (-3) impulses. This can be done even in children after superficial anaesthesia (2% pantocaine drops) to drain the middle ear. The laser perforation of 0.3 mm [symbol: see text] will close after a day and has to be re-opened in the office to avoid tubes. We do not yet know how often general anaesthesia and removal by suction of too viscous mucus remain nevertheless necessary. With the Er:YAG laser parts of the ossicles can be cut out of the intact chain, without contact and trauma, nearly without loss of bone tissue. This allows better radicality in removing cholesteatomas or scars with less destruction. 500 impulses of 50 mJ ablate 32 mg of bone, i.e. the weight of an incus.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Suitability of various lasers for interventions from the tympanic membrane to the foot plate (Er:YAG, argon, CO2 s.p.--, Ho:YAG laser]. 788 17

A 37 year old man with a 2 year history of progressive cognitive decline, unilateral tinnitus and deafness presented with complex partial seizures and a fever. On examination there was a sluggish right pupillary response but no other abnormal findings. Serum and CSF syphilis serology were both strongly positive. High dose intravenous penicillin therapy was complicated by a severe Jarisch-Herxheimer reaction (JHR) characterised by fever, obtundation, fluctuating upper motor neuron signs and complex visual and auditory hallucinations. These symptoms resolved over three days and the course of penicillin was completed. At discharge the patient's cognitive functioning was unchanged from the pretreatment state. He made gradual improvement over the following months but remains unable to live alone or work. Clinical, pathologic and radiologic findings of neurosyphilis are reviewed, as is the JHR, a self-limiting, systemic febrile response related to massive cytokine release that can occur in response to treatment of a number of bacterial infections. The similarities in pathophysiology of the JHR and the Septic Shock Syndrome are discussed, with particular reference to use of the JHR as a potential model for therapeutic agents in the treatment of septic shock.
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PMID:A case of neurosyphilis with a florid Jarisch-Herxheimer reaction. 1260 86