Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149958 (complex partial seizures)
 2,563 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Advances in fully three-dimensional (3D) image reconstruction techniques have permitted the development of a commercial, rotating, partial ring, fully 3D positron emission tomographic (PET) scanner, the ECAT ART. The system has less than one-half the number of bismuth germanate detectors compared with a full ring scanner with the equivalent field of view, resulting in reduced capital cost. The performance characteristics, implications for installation in a nuclear medicine department, and clinical utility of the scanner are presented in this report. The sensitivity (20 cm diameterx20 cm long cylindrical phantom, no scatter correction) is 11400 cps.kBq-1.ml-1. This compares with 5800 and 40500 cps.kBq-1.ml-1 in 2D and 3D respectively for the equivalent full ring scanner (ECAT EXACT). With an energy window of 350-650 keV the maximum noise equivalent count (NEC) rate was 27 kcps at a radioactivity concentration of approximately 15 kBq.ml-1 in the cylinder. Spatial resolution is approximately 6 mm full width at half maximum on axis degrading to just under 8 mm at a distance of 20 cm off axis. Installation and use within the nuclear medicine department does not appreciably increase background levels of radiation on gamma cameras in adjacent rooms and the dose rate to an operator in the same room is 2 microSv. h-1 for a typical fluorine-18 fluorodeoxyglucose (18F-FDG) study with an initial injected activity of 370 MBq. The scanner has been used for clinical imaging with18F-FDG for neurological and oncological applications. Its novel use for imaging iron-52 transferrin for localising erythropoietic activity demonstrates its sensitivity and resolution advantages over a conventional dual-headed gamma camera. The ECAT ART provides a viable alternative to conventional full ring PET scanners without compromising the performance required for clinical PET imaging.
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PMID:ECAT ART - a continuously rotating PET camera: performance characteristics, initial clinical studies, and installation considerations in a nuclear medicine department. 904 79

The development of secondary anaemia is a constant associated phenomenon of chronic renal failure. During its treatment by recombinant human erythropoietin (rHuEPO) erythropoiesis is accelerated and this increases demands on the supply of dietary erythropoietic precursors (Fe, pyridoxine, folic acid, vitamin B12). In particular as regards iron, frequently the dietary amount is not sufficient and supplementation is necessary. The objective of the present work is to compare oral and intravenous iron supplementation in the treatment of secondary anaemia by rHuEPO in patients with chronic renal failure treated by haemodialysis. A group of haemodialyzed patients (n = 61) treated with erythropoietin, where the serum ferritin concentration had dropped beneath 300 ng/ml, or the transferrin concentration below 0.20 was divided at random into two sub-groups. To group "A" Actiferrin was administered 3 x 1 cps/d (Ferrosi sulfas heptahydricus, corresponding to 34.5 mg elemental Fe and serine 129 mg per capsule, i.e. a total of 724.5 mg elemental Fe per week). To group "A" Ferrum-Lek was administered 1 vial per week by the i.v. route (Ferri oxidum saccharatum, corresponding to 100 mg elemental iron per week). The two groups were comparable as to the mean erythropoietin dose (50 U/kg per week) and the patients' mean age (61 years), the male/female ratio and the spectrum of basic diseases. After six weeks of treatment a comparable increase of the haematocrit and serum iron concentration was observed in both groups. As to transferrin saturation, there was a more marked increment in the intravenously supplemented group. The serum ferritin values in group "A" declined, while in group "F" they increased. After both types of iron supplementation a comparable increase of the haematocrit and serum iron concentration occurred, the iron reserves represented by serum ferritin differed however and from the long-term aspect they are in favour of intravenous iron supplementation in haemodialyzed patients treated with erythropoietin.
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PMID:[Iron supplementation during erythropoietin therapy in patients on hemodialysis]. 907 85