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Query: UMLS:C0149958 (complex partial seizures)
 2,563 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with right hemisphere complex partial seizures exhibited extreme emotional lability resembling mania, neologisms resembling those found in fluent aphasia, and hallucinations during ictal periods. The electroencephalographic and clinical findings in this case suggest that cortical and subcortical structures of the right hemisphere may play a role in mediating the expression of language content.
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PMID:Right hemisphere partial complex seizures: mania, hallucinations, and speech disturbances during ictal events. 333 19

A 40-year-old man developed an acute state of manic exultation when given carbamazepine for complex partial seizures. The symptoms subsided when carbamazepine was discontinued, but recurred when the drug was inadvertently given again. This observation does not accord with previous evidence of a beneficial psychotropic effect for carbamazepine in some epileptic patients and of some effect in the treatment of mania. Carbamazepine has been shown to have complex actions on multiple neurotransmitter and neuromodulator systems, and it is possible that paradoxical effects of this nature may occur in susceptible individuals, as has been found with other sedative and anticonvulsant agents. The patient recalled brief euphoric periods after seizures, which may suggest that carbamazepine exacerbated or prolonged preexisting cerebral dysfunction.
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PMID:Manic state with carbamazepine therapy of seizures. 379 91

In order to evaluate the effect of lateralization of epileptogenic lesions on mood changes (depression-mania) and anxiety (state and trait), twenty patients with complex partial seizures and nineteen controls were assessed with depression scales (Beck, Columbia M-D) and the State and Trait Anxiety Inventory. Nine patients had left temporal foci, eight had right foci, as assessed by the side of seizure onset during closed-circuit television-EEG telemetry recording. Left patients scored significantly higher than both right and control groups on depression and trait anxiety. Our results are consistent with those of previous reports on patients with localized epileptogenic and nonepileptogenic lesions. Patients with left side involvement seem more prone to experience dysphoric changes and depressive symptoms than those with right involvement.
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PMID:Depression and anxiety in complex partial seizures. 642 54

A 29 year old male with primary generalized seizures for 13 years stopped his anticonvulsants leading to an increase in seizure frequency. Five months later he developed a severe manic episode postictally which responded well to a combination of neuroleptics and anticonvulsants. Postictal psychoses usually follow complex partial seizures. Manic episodes are uncommon. This case had some similarities with other cases of postictal psychoses reported previously. It underlines the need for further investigation of several facets of this complex relationship between mood disorders and epilepsy.
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PMID:Postictal mania following primary generalized seizures. 1062 13