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Query: UMLS:C0149958 (complex partial seizures)
 2,563 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Giorgio de Chirico is one of the most admired and at the same time most discredited painters of the 20th century. As the 'inventor' of metaphysical painting, he has been considered as a precursor of Surrealism, while his later works have been harshly criticized as representative of the painter's decay. The mystery and dream-like atmosphere irradiating from his works has led to speculations that de Chirico may have taken his inspiration from migraine attacks or complex partial seizures. However, a careful study of his life and his own writings suggests that while de Chirico probably suffered from recurrent malaria, he had neither migraines nor epilepsy. De Chirico also denied that dreams were a major source of his inspiration, but he insisted on his fertile inner imagery, which allowed him to put in a new, poetic, often conflictual perspective, places and objects, which he had actually seen (Hofgarten arcades, Italian piazzas, statues, antique ruins, etc.) in Athens, Munich, Florence, Turin, Ferrare, and other towns. De Chirico was accused of self-plagiarism because he commonly used his former themes in new works, sometimes in what may look like servile copies of his early paintings. This 'replay syndrome' is quite unique in modern art, which has been dominated by the obligation, dogma and cult of newness and renewal. At odds with most of his contemporaries, Andy Warhol suggested that de Chirico made such recurrent series because 'he liked it'. Indeed, as a lifelong admirer of Nietzsche, de Chirico may just have applied the philosopher's concept of the 'eternal return', in which one is supposed to live and accomplish tasks that one would want to repeat forever. In that way, de Chirico's work should not be considered as that of a genius who fell into decadence, but may appear as a continuous, organized process to which organic brain dysfunction never contributed.
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PMID:The last myth of Giorgio De Chirico: neurological art. 2037 20

The Alice in Wonderland syndrome is a term applied to altered bizarre perceptions of size and shapes of a patient's body and illusions of changes in the forms, dimensions, and motions of objects that a patient with this syndrome encounters. These metamorphopsias arise during complex partial seizures, migraine headaches, infections, and intoxications. The illusions and hallucinations resemble the strange phenomena that Alice experienced in Lewis Carroll's Alice's Adventures in Wonderland. Charles Lutwidge Dodgson, whose nom de plume was Lewis Carroll, experienced metamorphopsias. He described them in the story that he wrote for Alice Liddell and her two sisters after he spun a tale about a long and strange dream that the fictional Alice had on a warm summer day. The author of this chapter suggests that Dodgson suffered from migraine headaches and used these experiences to weave an amusing tale for Alice Liddell. The chapter also discusses the neurology of mercury poisoning affecting the behavior of Mad Hatter character. The author suggests that the ever-somnolent Dormouse suffered from excessive daytime sleepiness due to obstructive sleep apnea.
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PMID:The Alice in Wonderland syndrome. 2429 Apr 80

The appearance of untreated severe hydrocephalus with long-term survival is infrequent; here we report a case with these characteristics, mild neurological alterations and kidney and skeletal anomalies. A female patient showed severe hydrocephalus (initially mistaken with hydranencephaly) at 4 years old and left kidney ectopia (initially mistaken with renal agenesis); however, she was derived to the neurology service until she was 12 years old, when she began to present migraine and seizures. At 13 years old the patient was diagnosed with arrested hydrocephalus secondary to aqueduct stenosis, and the seizures worsen thereafter from atonic seizures to complex partial seizures (at 14 years old), presenting generalized seizures at 15 years old. At 17 years old, the seizures were more frequent despite the anticonvulsant treatment and also presented automations, she was also diagnosed with genu recurvatinn and scoliosis. The seizures finally diminished and partially controlled at 19 years old. Despite a cerebral mantle < 2.0 cm at the computer tomography, the patient always presented a satisfactory intellectual development. In this case, the relatively good and long evolution of the severe hydrocephalus is probably related with the late-onset of the disease that permitted a better development of the brain; however, the worsening of the seizures after the hydrocephalus arrested, suggests that arrest is not necessarily associated with a compensation and better evolution of the disease, at least at the beginning of the process. The presence of kidney ectopia and skeletal alterations did not associate with a known genetic disease, however a possible inheritance mechanism is not discarded.
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PMID:SEVERE HYDROCEPHALUS, KIDNEY AND SKELETAL ANOMALIES IN A FEMALE PATIENT WITH MILD NEUROLOGICAL ALTERATIONS. 3020 73

History A 36-year-old left-handed woman with a history of developmental delay and medical refractory seizures since birth most recently presented with continuous simple partial seizures and occasional breakthrough complex partial seizures with postictal migraines. These were described as the patient "becoming pale with sinking to the floor and staring for approximately 1 minute with confusion thereafter." The patient had years of reported seizure freedom until 2010 when she was evaluated for intractable headaches, and electroencephalography revealed her focal subclinical status. At that time, ambulatory electroencephalography findings showed asymmetric left parietal-occipital high-amplitude spike-and-wave discharges in her best awake and alert state. Since that time, the patient developed and continues to have complex partial seizures every 2-3 months that are persistent despite the implementation of several medical regimens. At the time of recent presentation, the patient initially underwent unenhanced head CT in the emergency department followed by unenhanced MRI of the brain due to increased seizure activity at the patient's group home despite continued compliance with her antiepileptic regimen. Contrast material-enhanced imaging was not available at the time of recent presentation, so comparison was made with gadolinium-enhanced brain MRI performed approximately 9 years earlier (Figs 1-5).
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PMID:Case 284. 3268 58

History A 36-year-old left-handed woman with a history of developmental delay and medical refractory seizures since birth most recently presented with continuous simple partial seizures and occasional breakthrough complex partial seizures with postictal migraines. These were described as the patient "becoming pale with sinking to the floor and staring for approximately 1 minute with confusion thereafter." The patient had years of reported seizure freedom until 2010 when she was evaluated for intractable headaches, and electroencephalography revealed her focal subclinical status. At that time, ambulatory electroencephalography findings showed asymmetric left parietal-occipital high-amplitude spike-and-wave discharges in her best awake and alert state. Since that time, the patient developed and continues to have complex partial seizures every 2-3 months that are persistent despite the implementation of several medical regimens. At the time of recent presentation, the patient initially underwent unenhanced head CT in the emergency department followed by unenhanced MRI of the brain due to increased seizure activity at the patient's group home despite continued compliance with her antiepileptic regimen. Contrast material-enhanced imaging was not available at the time of recent presentation, so comparison was made with gadolinium-enhanced brain MRI performed approximately 9 years earlier.
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PMID:Case 284: Posterior Quadrantic Dysplasia. 3319 72


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