Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0149925 (
small cell lung cancer
)
6,491
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We aimed to unveil the clinical roles and biological function of lncRNA
TUBA4B
in on-
small cell lung cancer
(NSCLC). The relative expression level of
TUBA4B
was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of
TUBA4B
to clinical data of NSCLC patients was analyzed. We found
TUBA4B
was lower expressed in NSCLC and five cell lines. The lower expression of
TUBA4B
was remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. After overexpression of
TUBA4B
, cell proliferation ability of A549 and NCI-H1299 remarkably decreased. Our study ascertained low expression
TUBA4B
in NSCLC tissue, cell lines and is a poor predictor for prognosis and can regulate cell proliferation in NSCLC.
...
PMID:Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer. 2741 23
