Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0149871 (
deep vein thrombosis
)
12,364
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The pathophysiological mechanisms of venous thromboembolism are venous stasis, endothelial damage, and hypercoagulability, while less attention has been given to the role of both innate and native immunity. In this paper, we investigate the involvement of the activated immune system detected through some indicators such as TIM3 and
Dectin-1
expressed by T lymphocytes. TIM3 and
Dectin-1
, two surface molecules that regulate the fine-tuning of innate and adaptive immune responses, were evaluated in patients affected by
deep vein thrombosis
of lower limbs (DVTLL). CD3
+
, CD4
+
and CD8
+
T lymphocytes obtained from patients affected by DVTLL were analysed using fluorescence-conjugated antibodies for TIM3 and
Dectin-1
by an imaging flow cytometer. DVTLL patients showed a higher number of CD4
+
and CD8
+
T lymphocytes. TIM3 expression in T lymphocytes was very low in both DVTLL patients and controls. On the contrary, an increase in
Dectin-1
+
cells among CD4
+
and CD8
+
T lymphocytes from DVTLL patients was observed.
Dectin-1
is known to play a role in inflammation and immunity and our result suggests its potential involvement in thrombotic venous disease.
...
PMID:Dectin-1 and TIM3 Expression in Deep Vein Thrombosis of Lower Limbs (DVTLL). 3312 75
