Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A previously healthy woman was admitted to the intensive care unit (ICU) with severe H1N1 influenza. She had prolonged hospital stay due to multiple complications of critical illness, including pelvic deep vein thrombosis (DVT), which was treated with subcutaneous enoxaparin. The patient was referred to the ophthalmology service for bilateral proptosis. On examination, she had bilateral tense proptosis, worse on the left side with exposure keratopathy. Laboratory tests showed that she had thrombocytopenia and raised activated partial thromboplastin time (APTT). A CT scan revealed well-circumscribed soft tissue density lesions in the superolateral orbits and was reported as bilateral lacrimal gland enlargement. However, based on a clinical suspicion of subperiosteal hematoma collection, a diagnostic tap was performed. Following aspiration of six mls of dark blood from the left superior orbit, there was a reduction of proptosis with improvement in chemosis and resolution of exposure keratopathy. Enoxaparin is one of several antithrombotic agents which are increasingly being used for DVT prophylaxis in severely compromised patients. Furthermore, ICU patients ventilated for prolonged periods are at risk of developing chemosis and exposure keratopathy. Thus, the clinician should maintain a high index of suspicion in identifying subperiosteal hematomas, when managing such cases. The spontaneous bilateral vision threatening subperiosteal hematoma was probably caused by a combination of enoxaparin therapy and prolonged ventilation.
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PMID:Bilateral orbital haematomas in an anticoagulated patient with severe H1N1 influenza. 2129 3

Sjogren's syndrome is a chronic autoimmune condition characterized by reduced lacrimal and salivary gland secretions. In a minority of the cases, patients can develop rarer complications, such as vasculitis and, even less commonly, ischemic colitis. Herein, we present a challenging case of a 73-year-old woman with a background of Sjogren's syndrome (SS) who initially presented with a purpuric rash on the right leg. She was initially managed with antibiotics and referred for an outpatient rheumatology review. A few days later, she was readmitted to the hospital generally unwell with a widespread rash. She developed deep vein thrombosis and per rectal bleeding secondary to ischemic colitis. She had excellent response to medical management including steroid therapy and azathioprine. This case highlights the very rare complications of SS. Whilecutaneous vasculitis is not uncommon in primary Sjogren's, ischemic colitis is very rare and is a potentially serious complication, which requires prompt diagnosis and management.
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PMID:Challenging case of ischemic colitis, necrotic cutaneous vasculitis and thromboembolic disease in an elderly patient with Sjogren's syndrome. 3184 26