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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was performed to determine the accuracy of D-Dimer fibrin derivatives, thrombin-antithrombin III (TAT) complexes and prothrombin fragments 1 + 2 (F 1 + 2) determinations for the diagnosis of deep vein thrombosis (DVT). One hundred and sixteen consecutive patients referred to the angiology unit of our hospital for a clinically suspected DVT were investigated. They were submitted to mercury strain gauge plethysmography and to ultrasonic duplex scanning examination; in cases of inconclusive results or of proximal DVT (n = 35), an ascending phlebography was performed. After these investigations were completed, the diagnosis of DVT was confirmed in 34 and excluded in 82. One half of the patients were already under anticoagulant therapy at the time of investigation. The 3 biological markers were assayed using commercially available ELISA techniques and the D-Dimer was also assayed with a fast latex method. The normal distribution of these markers was established in 40 healthy blood donors. The most accurate assay for the diagnosis of DVT was the D-Dimer ELISA which had both a high sensitivity (94%) and a high negative predictive value (95%). The D-Dimer latex, TAT complexes and F 1 + 2 were far less sensitive and provided negative predictive values which ranged between 78 and 85%. In spite of positive and significant correlations between the levels of the 3 markers, their association did not improve their overall accuracy for detecting DVT. Therefore, with the exception of the D-Dimer ELISA, these markers were of little value for the diagnosis of DVT in this specific population.
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PMID:D-Dimers, thrombin antithrombin III complexes and prothrombin fragments 1+2: diagnostic value in clinically suspected deep vein thrombosis. 202 37

To evaluate the relationship between maximum venous outflow (MVO) of the leg and development of deep vein thrombosis (DVT), venous occlusion plethysmography (VOP) using a Mercury strain gauge was carried out in 56 unilateral DVT patients. The data from these patients were compared with those obtained from several control groups. Then, the relationship between plethysmographic and 9 clinical variables was statistically analysed in the normal legs of these patients. The mean MVO of the normal legs of these patients was significantly higher than that of the affected legs, but it was significantly lower than those of normal controls and patients with mild congestive heart disease. However, it was similar to those in patients with lymphedema and obese men. A decrease in the MVO of the normal legs of these patients was noted in older females with femoral vein obstruction of the left leg, with a shorter number of days from the onset of symptoms or with higher values for the obesity index and calf circumference. Significant correlations between the MVO and the obesity index (r = -0.59), venous capacitance (VC, r = 0.49) and the number of days from the onset of symptoms (r = 0.40) were found in the normal right legs of these patients (n = 40). In the normal left legs (n = 16), on the other hand, significant correlations were found between the MVO and the VC (r = 0.65) and the MVO and age (r = -0.65).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Maximum venous outflow and development of deep vein thrombosis. 203 May 45

Associated ultrasonic Doppler study (D) and plethysmography (P) were evaluated as compared to phlebography in diagnosis of venous thrombosis of the lower limbs (TVP). Probes (5 and 7.5 MHz respectively) were used in D for examination of proximal and calf veins. Plethysmography using a mercury ring gauge (Perivein, ETNA) was considered pathologic if filling volume was less than 1.5 vol% and/or emptying volume less than 40 ml/min/100 ml. One hundred and four patients hospitalized in an internal medicine department for suspected deep venous thrombosis were studied, including 97 for whom phlebography interpretation was unmistakable: 11 calf vein, 28 collector trunk and 42 total limb involvement TVP. In these localizations, D sensitivity was respectively 55, 72 and 100% (mean 85.5%) and that of P 63.5, 68 and 88% (mean 77.7%); association of D or P improved sensitivity: 82, 82 and 100% (mean 91.5%). Specificity was 86.6% for D, a poor 62.5% for P and 93.5% for associated D and P. The results are comparable to those in the literature but disappointing for diagnosis of isolated calf vein TVP. False-negatives in both D and P were due to strong collateral circulation or limited thrombus extension.
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PMID:[Non-invasive diagnosis of phlebothrombosis of the limbs. Prospective evaluation of mercury gauge plethysmography associated with ultrasonic Doppler]. 217 46

Calf blood flow was measured in 19 patients with deep venous thrombosis (DVT) of the lower limb using a mercury strain gauge. The affected limb had a significantly (P less than 0.05) higher blood flow (2.9 +/- 1.4 ml/min. 100 g of tissue) then the contralateral limb (2.3 +/- 1.2 ml/min. 100 g). Blood flow velocity in the common femoral artery measured with a pulsed Doppler ultrasound flowmeter in 13 patients was also significantly (P less than 0.05) higher in the limb with DVT (6.6 +/- 2.8 cm/s) compared to the contralateral limb (5.3 +/- 3.0 cm/s). Interstitial fluid hydrostatic pressure (Pif) was measured by the "wick-in-needle" technique in the deep posterior compartment of the leg. There was a significant (P less than 0.001) increase in the limb with DVT (6.3 +/- 5.5 mmHg) compared to the contralateral limb (1.2 +/- 3.4 mmHg).
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PMID:Arterial blood flow in deep venous thrombosis of the lower limbs. 350 62

Mercury strain gauge venous occlusion plethysmography is a non invasive exploration of the lower limb venous hemodynamic. Classically, venous distensibility (delta V/V %) is expressed in terms of time during venous inflow (venous occlusion) and venous outflow (after cuff deflation). The authors proposed to express the total flow Q of the limb (obtained by a differentiator of the electric signal of the strain gauge) in terms of the venous distensibility (delta V/V %) whatever recording a top each second. This new representation Q = f(delta V/V) permit a more acute visualisation of the initial part of the venous emptying: more differentiation between venous drainage and systolic arterial waves, acceleration then deceleration of the venous emptying, return of the venous wall to its initial position later than venous emptying, active venous constriction. Some parameters are proposed to described this curve and the values obtained in 50 patients without and 10 patients with deep venous thrombosis are reported.
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PMID:[The flow-volume curve. Expression of emptying as a function of venous distensibility]. 358 86

Mercury gauge plethysmography with venous occlusion (PJC) is an atraumatic procedure for the diagnosis of deep venous thrombosis (TVP) of the lower limbs: 103 patients were studied both by plethysmography and phlebography (the reference examination). 54 were hospitalised for a suspicion of pulmonary emboli (EP), 21 for clinical phlebitis and finally 28 subjects had the studies as part of a systematic work-up. 60 cases of TVP of the lower limbs were discovered: 47 were recent, 34 were proximal and 13 sural. The clinical examination failed to reveal these in 36% of cases; the phlebographic and PJC results were concordant for 75% of cases: PJC seemed particularly to be the technique of high sensibility for the early diagnosis of proximal TVP but of a lesser interest for the early diagnosis of peripheral TVP (sensibility 69%). This examination makes an important contribution: for the early diagnosis of hidden proximal TVP; for the diagnosis of EP in its deceptive forms where the presence of a peripheral embolic focus constitutes one weighing factor towards the diagnosis of peripheral thrombo-embolic disease (MIE); for the control of anti-coagulant therapy in the clinic where the local inflammatory process and the biology controlling the consumption of heparin are jointly observed and the study of venous drainage allows an appropriate decision to be made as to the cessation of anticoagulant therapy and minimises the risk of recurrence or avoiding postphlebitis disease by a prolonged treatment.
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PMID:[Thromboembolic disease in pneumology. Value of mercury-gauge plethysmography with venous occlusion]. 408 Dec 78

Previous research has shown that MVO (Maximum Venous Outflow), VR (Venous Reflux), VE (Venous Emptying) and the respiratory waves recording are useful in differentiating occlusion and recanalization in postphlebitic syndrome. In the present work strain-gauge plethysmography was employed to quantitate the venous function after deep venous thrombosis of the legs. The studies were performed in a vascular laboratory with controlled temperature (23 to 25 C); records were obtained by a plethysmograph Parks mod. 270 connected to a Hewlett-Packard multi-channel mod. 7700. 17 patients (12 males, 5 females), mean age 55 years (range 24-75) that presented femoropopliteal thrombophlebitis documented by phlebography at the admission to the hospital were examined. MVO with and without superficial veins occlusion was measured by a mercury in silastic strain-gauge placed circumferentially about the calf. A pneumatic cuff thigh was inflated to 60 mm Hg. VE was measured in patients lying in inclined bed with the lower extremities 100 cm below the heart level compressing the calf with a pneumatic cuff 10 times for 5 seconds; the strain-gauge was placed on the foot level. VR after Valsalva's maneuver and the respiratory waves were recorded by a strain-gauge positioned at the maximum girth about the calf in patients lying on inclinated bed with the lower extremities 50 cm below the heart level. The result are here indicated: (Table: see text) There was differences in the evolution of venous function after deep venous thrombosis of the legs for each patient. Strain-gauge plethysmography may become evaluable non invasive technique in the evaluation of deep venous thrombosis evolution in the legs. The therapeutic assessment of postphlebitic syndrome.
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PMID:[Strain-gauge plethysmography in the evaluation of the evolution of deep vein thrombosis of the legs]. 647 45

Mercury strain gauge plethysmography will play an increasingly important role in vascular function exploration, participating in the detection of deep vein thrombosis and replacing arteriopathy in its arterio-capillary context. This required the development of a standardized reporting form for entering results of venous and arterial examinations and providing simple, clear evaluations of vascular function to assist therapeutic decisions. A standardized sheet in the form of rapidly scanned graphs and tables was established, this simplified representation facilitating decision making. Wider use of this type of form is proposed, with the aim of providing uniformity of data from mercury strain gauge plethysmography and statistical and computerized analysis of results of multicentre studies.
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PMID:[Development of a standardized form for mercury gauge plethysmography of veins and arteries]. 652 73

In 33 patients with acute deep venous thrombosis of the lower extremity, all verified by phlebography, and in 36 healthy subjects arterial inflow, venous volume and maximum venous outflow were measured by mercury-strain gauge plethysmography. The measurements were performed simultaneously in both legs at the calf and foot level with a cuff pressure of 60 mm Hg for 4 min. In contrast to thrombotic occlusions proximal to the knee and multi-level thromboses, which could be identified by a significantly (p less than 0.001) reduced venous volume and maximum venous outflow (measurement at the calf level), isolated calf vein thromboses could not be detected even by sensing from the foot level or only if all three deep veins of the calf were occluded. The best diagnostic criterion for proximal deep venous thrombosis was the correlation of maximum venous outflow and venous volume (83% right positive), if these parameters were determined from the calf. The results indicate that deep calf vein thrombosis can be detected, even if sensed from the foot, only in cases with cross sectional thrombotic occlusions.
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PMID:[Comparative plethymography studies of arterial and venous hemodynamic parameters in the calf and foot in deep venous thrombosis]. 684 49

Mercury strain gauge plethysmography with programme and ECG synchronous venous occlusion was tested in 14 normal subjects (28 lower limbs). The results obtained in the case of recent deep venous thrombosis of the lower limbs were compared with those of phlebography ni 39 patients: 26 proximal thromboses and 15 calf thromboses. Interpretation of the results must take into account the strict conditions under which the plethysmography was carried out: position of the subject and especially of the lower limbs and the technical characteristics of the apparatus used. Specificity was 96.4% for the group of normal subjects. Sensitivity calculated for all the cases of venous thrombosis studied was 97.5% whilst it was 100% for proximal thromboses (femoral and iliac).
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PMID:[Mercury gauge plethysmography. Sensitivity and specificity compared with standard phlebography (author's transl)]. 707 78


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