Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There are many reports of how IPC is used effectively in the clinical setting; including the prevention of deep venous thrombosis, improvement of circulation in patients with lower extremity arterial diseases, reduction of lymphoedema, and the healing of venous ulcers. However, despite the widely accepted use of IPC, it is still unclear how IPC actually exerts its beneficial effects. The exact physiological mechanisms of action are unknown. The clinical utility of IPC and the putative mechanisms by which IPC could exert its therapeutic effect will be reviewed. The paper will examine the mechanical effects of IPC exerted on the lower extremity, and the subsequent biochemical changes in the circulation. In vitro studies of the effects of mechanical stress such as compressive strain and shear on cultured endothelial cells, and their clinical relevance to IPC will also be reviewed.
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PMID:Intermittent pneumatic compression devices -- physiological mechanisms of action. 1135 11

Neurosurgical patients are at significant risk of thromboembolic complications. A survey of 58 consultant neurosurgeons in United Kingdom confirmed that 84.5% regularly used some form of prophylaxis. For all forms of neurosurgery, the most preferred method of prophylaxis was mechanical (graduated compression stockings-TEDS and intra-operative pneumatic calf compressors-IPC) or in the post-operative period a combination of mechanical methods and low molecular weight heparin (LMWH). LMWH was rarely administered in the perioperative period. The majority of neurosurgeons believed that TEDS and LMWH reduced post-operative DVT (79% and 90%, respectively) and PE (43% and 67%), but 29% associated LMWH with bleeding complications. A review of current literature revealed that TEDS, IPC, and LMWH are effective in reducing the incidence of DVT, but the evidence over the safety of heparin is inconclusive in neurosurgical patients. There is still room for improvement as a minority of neurosurgeons continue to ignore the importance of prophylaxis against thrombo-embolism in neurosurgery.
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PMID:Attitudes to the use of prophylaxis for thrombo-embolism in neurosurgical patients. 1285 88

Intermittent pneumatic compression is a well-known technique, which can be used for several therapeutic treatments like sports recovery, lymphoedema drainage, deep vein thrombosis prevention or others, which may require very different operating characteristics as regards the desired pressure values and the operating velocity. The performance and the effectiveness of the device are often difficult to predict and must be usually optimized through empirical adjustments. This article presents a general method based on the mathematical modelling of a generic IPC system, aimed at studying and developing such a device with physical and dynamical characteristics suitable for the intended application.
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PMID:A model-based method for the design of intermittent pneumatic compression systems acting on humans. 2435 83

Thromboembolic disease (TED) is a considerable social and health problem. The solution evidently consists in the prevention of TED in clinical fields, not in the treatment itself. We can assume that effective prevention consequently reduces the cost of the following treatment. A lethal pulmonary embolism (PE) can be the first and the final clinical manifestation in patients with an asymptomatic deep venous thrombosis. This makes the systematic prevention of venous thromboembolism in higher risk patients necessary. Unfortunately, pharmacological prevention has been used less than would be needed. Inseparable from the TED prevention are physical methods. Pharmacological possibilities of the thromboembolic disease prevention were significantly extended within the past decade. To ensure the TED prevention after the total replacement (TEP) of hip and knee joints the following rules need to be observed: the TED prevention should be effected with LMWH, fondaparinux, dabigatran, rivaroxaban or apixaban for a period of 28-35 days after the hip joint replacement surgery and for 14 days after the knee joint replacement. The use of ASA, dextran and UFH as a thromboprophylaxis after the hip and knee joint TEP is not justified within the Czech Republic. Physical means (graduated compression stockings or IPC) can be used to support the recommended pharmacological treatment, they should not be used individually except in cases where pharmacological thromboprophylaxis is contraindicated.Key words: apixaban - dabigatran - LMWH - rivaroxaban - total hip and knee joint replacement - thromboembolic disease.
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PMID:[Acute and chronic anticoagulation therapy in relation to joint replacements]. 2625 75