Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary thrombosis of the deep veins of the upper arms accounts for less than 2% of total cases of deep venous thrombosis, and fewer than 10 reported cases of venous thromboembolism in association with oral contraceptive (OC) use have involved the upper extremity. This article describes the case of a 20-year old woman with recurrent arm swelling and pain who had been in good health until developing a small area of redness in her right arm and fever to 99.8 degrees Fahrenheit 6 weeks previously. The condition had been diagnosed as spider bite, for which no medication was given, and cellulitis with axillary lymphadenopathy, for which oral antibiotics were prescribed. Gradual improvement in pain and swelling occurred, but the arm did not return to normal size or consistency. Hospitalization and treatment with 9 days of intravenous Cefamandole provided some resolution. The patient had taken OCs for 2 1/2 years to regulate menses and was a cigarette smoker. She was discharged on oral Tetracycline but was referred for further evaluation because of persistent symptoms. The physical examination was normal except for an increased right upper extremity circumference, increased turgor of upper arm tissues, and some tenderness along the axillary vein and in the axilla itself. A venogram showed complete obstruction of the axillary and subclavian veins on the right with remarkable collateral circulation. The superior vena cava was patent. Treatment with intravenous Heparin followed by oral Warfarin produced no improvement in clinical condition. Primary upper extremity thrombosis is generally a disease of young men. In this case OCs may have served as a thrombogenic risk factor.
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PMID:A painful swollen arm in a young woman. 657 28