Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

New plasma assays for fibrin(ogen) degradation products have become available which are based upon monoclonal antibodies and can be performed in plasma. In this study we have evaluated four of such specific enzyme immuno assays i.e.: for the total of degradation products of fibrin and of fibrinogen (TDP), fibrin degradation products (D-dimer and FbDP) and fibrinogen degradation products (FgDP) in patients suspected of having deep venous thrombosis of the leg (DVT) and patients with cirrhosis of the liver. DVT was assessed by impedance plethysmography (IPG). In each of the (sub) groups of patients, a very good correlation (0.90 less than r less than 0.98) was observed between the actually measured TDP values and the calculated sum of the separately measured FbDP and FgDP levels. Only 2% (5 patients) of the cases showed a discrepancy of more than a factor two between the found TDP values and the calculated sum of the measured FbDP and FgDP levels. About 90% of the fibrin degradation products were crosslinked. FbDP levels correlated well with the FgDP levels (0.72 less than r less than 0.94) and D-dimer levels (0.82 less than r less than 0.91) in both patients with DVT and cirrhotics. In those patients also a good correlation (0.67 less than r less than 0.83) was observed between FgDP and D-dimer levels, but not in patients suspected of having DVT but with a normal IPG test result. Secondary fibrinolysis appeared to be accompanied by fibrinogenolysis.
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PMID:Correlations between plasma levels of fibrin(ogen) derivatives as quantified by different assays based on monoclonal antibodies. 195 61

This study was carried out in order to compare the coagulation balance in patients with colorectal cancer before and after surgical removal of tumor with an age matched non-malignancy control group. Furthermore, it was studied whether preoperative coagulation state in cancer patients was correlated to the postoperative development of deep venous thrombosis (DVT) diagnosed by venography. Plasma was collected preoperatively in 93 cancer patients and 30 controls, and postoperatively on day one, two, seven, and ninety in 88 cancer patients and 18 controls. Prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex (TAT), and total fibrin(ogen) degradation products (TDP) were quantitated in plasma by enzyme linked immunosorbent assays (ELISA). As compared to controls, patients admitted for cancer treatment displayed significantly higher levels of F1 + 2 and TAT. Patients suffering from advanced colorectal cancer had significantly higher levels of TAT and TDP as compared to patients with localized colorectal cancer. Twenty-three percent of cancer patients developed DVT postoperatively. Preoperatively these patients displayed significantly higher TDP levels, and postoperatively higher levels of F1 + 2, TAT, and TDP compared to cancer patients without DVT. The marked activation of blood coagulation and fibrinolysis observed in all patients following major abdominal surgery was even more pronounced in patients not cured for cancer.
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PMID:Pre- and postoperative state of coagulation and fibrinolysis in plasma of patients with benign and malignant colorectal disease--a preliminary study. 890 90