Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0149871 (
deep vein thrombosis
)
12,364
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
18
F-
GP1
is a derivative of elarofiban with a high affinity to activated platelet glycoprotein IIb/IIIa (GPIIb/IIIa) and favorable in vivo characteristics for thrombus imaging in preclinical models. We aimed to explore the detection rate of thromboembolic foci with
18
F-
GP1
positron emission tomography/computed tomography (PET/CT) in patients with acute venous thromboembolism (VTE), and to evaluate the safety, biodistribution, pharmacokinetics, and metabolism of
18
F-
GP1
.
Methods:
We studied patients who had signs or symptoms of acute
deep vein thrombosis
(
DVT
) of the leg or acute pulmonary embolism (PE) within 14 days prior to
18
F-
GP1
PET/CT, and had thromboembolic foci confirmed by conventional imaging (
n
= 10 for
DVT
and
n
= 10 for PE). Dynamic whole-body PET/CT images were acquired for up to 140 minutes after injection of 250 MBq of
18
F-
GP1
.
Results:
18
F-
GP1
PET/CT was well tolerated without any drug-related adverse events, and showed high initial uptake in spleen, kidney, and blood pool, followed by rapid clearance. The overall image quality was excellent and allowed interpretation in all patients.
18
F-
GP1
PET/CT identified thromboembolic foci in all 20 patients with either
DVT
or PE. Vessel-level analysis revealed that
18
F-
GP1
PET/CT detected 89% (68/76) of vessels with
DVT
, and 60% (146/245) for PE. Importantly,
18
F-
GP1
PET/CT showed increased uptake in 32 vessels that were not detected by conventional imaging, of which 25 were located in distal veins of the lower extremity in 12 patients. A positive correlation was found between
18
F-
GP1
uptake and P-selectin-positive circulating platelets (
r
= 0.656,
P
= 0.002).
Conclusion:
18
F-
GP1
is a promising PET tracer for imaging acute VTE in patients.
18
F-
GP1
PET/CT may identify thrombi in distal veins of the leg, where conventional imaging has limitations.
...
PMID:Glycoprotein IIb/IIIa receptor imaging with
18
F-GP1 positron emission tomography for acute venous thromboembolism: an open-label, non-randomized, first-in-human phase 1 study. 2995 14
