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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A double blind study of 134 patients was undertaken to compare the effectiveness of hydroxychloroquine sulfate, Plaquenil, and heparin in the prophylaxis of deep venous thrombosis. By the 125I fibrinogen scanning technique, deep venous thrombosis was detected in six patients in the placebo group, in one patient in the Plaquenil group and none in the heparin group. These results indicate that both heparin and Plaquenil do diminish the incidence of thrombosis.
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PMID:Prophylaxis of deep venous thrombosis by hydroxychloroquine sulfate and heparin. 33 43

The rate of postoperative deep vein thrombosis was studied by the 125I-fibrinogen method in 35 patients after total hip replacement. 12 out of 18 patients treated prophylactically with hydroxychloroquine sulfate developed deep vein thrombosis compared with 11 out of 17 patients in the control group. Platelet aggregability was inhibited in vitro by high concentrations of hydroxychloroquine sulfate, but these concentrations were not obtained in vivo and platelet aggregation was not limited in patients treated with hydroxychloroquine sulfate (Plaquenil).
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PMID:Clinical and experimental evaluation of the thromboprophylactic effect of hydroxychloroquine sulfate after total hip replacement. 700 79