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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Isotope phlebography is a reliable examination in the diagnosis of deep venous thrombosis. Too complicated and expensive to be suggested for the purpose of routine detection, it nevertheless is of definite interest in three circumstances: --Suspicion of pulmonary embolism, with visualisation of any possible reservoir of peripheral clot and proof of the embolism. --Postoperatively, for repeated follow up to evaluate permeability after surgical procedures. --Finally, dynamic information by calculation of transit time of the radioactive embolus. Combined with Doppler measurement of peripheral venous pressures, it reflects the emptying capacities of a limb affected by post-phlebitis syndrome and hence plays a role in the decision to stop oral anticoagulants.
J Mal Vasc 1982
PMID:[Isotope phlebography. Value and limitations. Reliability in recent deep venous thrombosis of the lower limbs (author's transl)]. 707 75

The diagnosis of deep venous thrombosis of the lower limbs often poses difficult problems. Whilst it is usually obvious in cases of massive thrombosis of the ilio-femoral veins, it is often much more difficult in the presence of isolated minimal obstruction of a leg vein. Clinical findings are often inadequate, various laboratory investigations fail to provide definite arguments and only phlebography can confirm venous occlusion. Ultrasound examination by Doppler effect can offer great service in all cases by confirming the clinical impression and aiding in determining the indication for radiological investigation. The reliability of the examination is excellent above the knee and much more hazardous below. At any event, it is based upon a strict protocol and depends essentially upon the experience of the individual performing it.
J Mal Vasc 1982
PMID:[Doppler examination. Specificity and sensibility in comparison with standard phlebography in recent deep venous thrombosis of the lower limbs (author's transl)]. 707 76

Although phlebocavography remains the ideal technique of diagnosis and reference, impedance plethysmography is a simple non-invasive technique which records variations in impedance of a limb segment through which a H.F. current is injected and with distal venous occlusion. Variations in impedance go hand in hand with variations in volume. It is thereby possible to demonstrate any obstacle to venous flow, either of an obstructive type if there is thrombosis of the major proximal collecting vessels, or of a restrictive type if there is thrombosis in the leg. The technical conditions of the examination and measurement are here fundamental and hence the value of a specially designed apparatus and multi-input abacuses in order to determine indices of emptying, filling and filling rate with simultaneous examination of both limbs. The method is selective for the diagnosis of recent deep venous thrombosis: 83% correlation between impedance and phlebography, 16% false positive and 1% false negative, reliability at the level of the thigh in 98% of cases, lesser reliability in the calf though the score can be improved and touch 94% by comparison of the two legs (Franco). Wuydin has reported a specificity of 85% and a sensitivity of 96%. This reliable, specific, objective, atraumatic, inexpensive and easily repeatable method may be used to give an overall quantification of a proximal obstructive thrombosis and define the existence of a thrombosis in the calf.
J Mal Vasc 1982
PMID:[Impedance plethysmography. Comparison of sensibility and specificity in recent deep venous thromboses of the lower limbs (author's transl)]. 707 77

Mercury strain gauge plethysmography with programme and ECG synchronous venous occlusion was tested in 14 normal subjects (28 lower limbs). The results obtained in the case of recent deep venous thrombosis of the lower limbs were compared with those of phlebography ni 39 patients: 26 proximal thromboses and 15 calf thromboses. Interpretation of the results must take into account the strict conditions under which the plethysmography was carried out: position of the subject and especially of the lower limbs and the technical characteristics of the apparatus used. Specificity was 96.4% for the group of normal subjects. Sensitivity calculated for all the cases of venous thrombosis studied was 97.5% whilst it was 100% for proximal thromboses (femoral and iliac).
J Mal Vasc 1982
PMID:[Mercury gauge plethysmography. Sensitivity and specificity compared with standard phlebography (author's transl)]. 707 78

Twenty four patients suffering from unilateral venous disturbances revealed by Doppler and secondary to a deep venous thrombosis were examined. The calf venous haemodynamics was analyzed by use of a strain-jauge plethysmograph. We determined the increase in venous volume due to the inflation of a thigh pneumatic cuff (pressure at 20, 40 and 60 mm Hg; delta V20, delta V40, delta V60). The maximal venous output (Vout) was measured after a quick release of the 60 mm Hg pressure. The maximal venous drainage (VMM) was assessed during a rhythmic exercise (tiptoeing) while standing; delta V20, delta V40 and delta V60 were nearly constantly reduced on the abnormal side (t of Student respectively 3.49; 6.09 and 5.07). Vout dropped proportionaly to delta V60. Some abnormalities due to valvular insufficiency were frequently present in the beginning of the inflation curve at the level of the abnormal limbs. VMM was nearly always largely decreased on the affected side (t = 5.43). The unilateral flow disturbances displayed by the Doppler were regularly going with abnormalities of the capacitive system, well demonstrated by comparison with the non-affected limbs.
J Mal Vasc 1982
PMID:[Sequelae of unilateral deep venous thrombosis in plethysmography of the calf]. 714 24

Recent deep vein thrombosis of the iliofemoral segment often leads to pulmonary embolism and to impaired valve function. Although more common, occlusions in the calf veins are less dangerous, and often a self-limiting disorder as almost half of these thrombi lyse spontaneously. Approximately 70% of fresh deep venous thrombi dissolve under intensive and prolonged thrombolytic treatment with streptokinase and long-term follow-up studies indicate that normal valve function is preserved in those patients in whom thrombus clearance was obtained. Thrombosis with streptokinase or urokinase appears to be the current treatment of choice for most cases of massive and severe, life-threatening pulmonary embolism; those patients surviving more than an hour or so after massive infarction comprise a prognostically better group, in whom the chances of surviving embolectomy is today smaller than the probability of survival without surgery but with thrombolytic treatment. Obviously there are problems in the evaluation but also in the thrombolytic treatment with streptokinase and urokinase of deep venous thrombosis and pulmonary embolism. These problems do not concern the principle of thrombolysis, but are largely due to the fact that the drugs so far used also induce a systemic fibrinogenolysis resulting in a bleeding risk. There is already good evidence that tissue activator of plasminogen is highly specific for fibrin and can induce thrombolysis in experimental animals without inducing systemic fibrinogenolysis.
J Mal Vasc 1981
PMID:[Actual state of thrombolytic treatment of recent vein thrombosis and pulmonary embolism (author's transl)]. 719 77

Three angeiologists from different regions and in different ways suggest, on the basis of their experience, a method for the management of the non-hospitalised patient suspected of suffering from a deep venous thrombosis of the lower limbs. They consider the early clinical diagnosis, clinical forms, differential diagnosis and the special investigations which must be prescribed, remembering a therapeutic trial with heparin. First they deal on the one hand with systemic treatment, i.e. anticoagulants and their contraindications, anti-inflammatory agents, vasodilators and procaine, and secondly local treatment. The authors conclude in the need for a rapid and precise diagnosis and treatment adapted to each individual case, closely observed and continued until a return to normal.
J Mal Vasc 1980
PMID:[The diagnosis and treatment of recent deep venous phlebitis outside hospital (author's transl)]. 746 58

Recombinant hirudin (HBW 023) has a pure and specific antithrombotic activity. It could be more effective than heparin in the treatment of deep venous thrombosis. Its half life is about three hours when administered intravenously which requires continuous infusion whereas subcutaneous administration can ensure stable plasma concentrations and antithrombotic activity over a period of approximatively 12 hours. The aim of the study was to check the safety and clinical and radiographic efficacy of recombinant hirudin administered subcutaneously to patients with recent deep venous thrombosis and to analyse the pharmacokinetics of the product and its effects on tests of coagulation. Ten patients were treated with 0.75 mg/kg of subcutaneous recombinant hirudin twice a day for 5 days. Anticoagulation was performed with standard heparin and acenocoumarol. Bilateral phlebography, pulmonary angiography or ventilation and perfusion scintigraphy were carried out before and on the 5th day of recombinant hirudin treatment. The activated cephalin time and standard anticoagulant tests and the plasma kinetics of recombinant hirudin were assayed between the 1st and 12th hour on the first and fifth days of treatment. The clinical course was simple in all but one patient who had a recurrence of pulmonary embolism on the 4th day justifying thrombolytic treatment. No haemorrhagic complications or secondary biological effects were observed. On the 5th day, control phlebography was unchanged or improved in all patients. The peak plasma concentration of recombinant hirudin was observed between the 3rd and the 4th hour following subcutaneous injection. The activated cephalin time was increased in parallel with increased concentrations of recombinant hirudin.(ABSTRACT TRUNCATED AT 250 WORDS)
Arch Mal Coeur Vaiss 1995 Mar
PMID:[Subcutaneous recombinant hirudin in the treatment of deep venous thrombosis. A pharmacokinetic study]. 748 86

The positive and negative clinical symptoms and signs of deep venous thrombosis are both insensitive and non-specific. Venography is the reference investigation: Duplex ultrasonography is the usual diagnostic procedure for distal deep venous thrombosis but it is less reliable in proximal lesions. The sensitivity of plethysmography in proximal deep venous thrombosis is high but the diagnosis of isolated calf vein thrombosis and non-obstructive proximal thrombosis escape diagnosis in this technique. Most cases of deep venous thrombosis occur after major surgery, during pregnancy, in the post-partum period, after prolonged immobilisation and in obese patients or those with varicose veins. Congenital and acquired causes should also be investigated when spontaneous deep venous thrombosis occurs or when the condition complicates minor surgical trauma in a young patient. The incidence of deep venous thrombosis varies with the type of surgical procedure: 25% in general surgery, 50% after hip or knee arthroplasty, 43% after fracture of femur, 24% after neurosurgery. Graduated pressure stockings should be used for the prevention of deep venous thrombosis. Other measures include aspirin, dextran, oral and subcutaneous anticoagulants, non-fractionated and low molecular weight heparins. The relative efficacy of these different measures is discussed with respect to each type of surgical procedure.
Arch Mal Coeur Vaiss 1995 Jan
PMID:[Prevention of deep venous thrombosis]. 764 53

The authors report the case of a 10 year old child who presented with an uncomplicated deep venous thrombosis associated with an antiphospholipid syndrome. The diagnosis was established by the finding of spontaneous prolongation of the activated cephalin time, the finding of a lupus-like antibody and an anti-cardiolipin antibody. The clinical outcome was good with oral anticoagulants but a recurrence was observed when they were stopped. The authors discuss the question of the duration of preventive therapy.
Arch Mal Coeur Vaiss 1995 May
PMID:[Antiphospholipid syndrome in children. Apropos of a case]. 764 91


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