Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There is a lack of information on the use of contraceptives among women with sickle cell disease in the United Kingdom, and 150 babies are born with sickle cell disease every year. This study examines the questionnaire responses of 156 women who had sickle cell disease and were known to the hematology departments and sickle cell centers in north London. 42 of the women had sickle cell hemoglobin C disease; 12 women had sickle thalassemia disease, and 102 had homozygous sickle cell disease. 149 were sexually active. The mean age was 28.4 years. 100 of the women had 207 pregnancies of which 133 were unplanned. 25 women with 31 pregnancies miscarried. 31 women (39 pregnancies) terminated the pregnancies for social or medical reasons. 4 (3 with homozygous sickle cell disease and 1 with sickle cell thalassemia) of the 67 women, who used combined oral contraceptives, reported increased crises, and 2 women, with homozygous sickle cell disease, reported deep vein thrombosis. 54 of the 148 sexually active patients had been counseled not to get pregnant. Only 3 women said this advice influenced their plans. There were only 44 women (28%) who adequately understood the inheritance patterns of sickle cell disease although 94 (60%) knew about the possibility of prenatal diagnosis. Many factors affect decision- making including a poor obstetric history and rejection of abortion on moral grounds. 45% have used oral contraceptives at one time or another and 19% used the intrauterine device. This is similar to use patterns in North America. The medical community may to blame for the inadequate use of contraceptives, because of not knowing which contraceptives to recommend in these cases. There are no contraindications to prevent sickle-cell women from using oral contraceptives.
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PMID:Contraceptives, counselling, and pregnancy in women with sickle cell disease. 840 Sep 60