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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The following case report presents a rare complication, bilateral adrenal hemorrhage, following low dose heparin prophylaxis for deep vein thrombosis in a 59-year-old total hip replacement patient. Symptoms associated with adrenal hemorrhage included nausea, vomiting, epigastric pain, increased temperature and white blood-cell count, and a drop in the hematocrit. At no time either pre- or postoperatively were hematological studies abnormal.Adrenal hemorrhage has been documented following therapeutic doses of heparin but is exceedingly rare following low doses of the drug. It has rarely been diagnosed before death occurred. It is concluded that use of low doses of heparin for prevention of deep vein thrombosis is of limited efficacy in patients undergoing total hip replacement surgery and its routine use is therefore not recommended.
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PMID:Bilateral adrenal hemorrhage: a complication of prophylactic anticoagulation. 2482 88

BACKGROUND Adrenal hemorrhage is an uncommon and under-recognized disorder with a wide array of etiologies ranging from pregnancy to septic shock. It is one of the complications of anticoagulation therapy, including direct anticoagulant medications. CASE REPORT Here, we present a case of a 68-year-old female with recent right knee arthroplasty who was on rivaroxaban for deep vein thrombosis (DVT) prophylaxis presented to the emergency department (ED) for severe acute onset abdominal pain, computed tomography (CT) of abdomen and pelvis revealed possible left adrenal hemorrhage that was confirmed with magnetic resonance imaging (MRI). On repeat CT, her unilateral adrenal hemorrhage converted to a bilateral adrenal hemorrhage (BAH) and, as a result, the patient developed adrenal insufficiency. CONCLUSIONS An undiagnosed and untreated adrenal hemorrhage can have catastrophic consequences, leading to adrenal insufficiency with potential shock and death. Therefore, it is important for clinicians to have an increased awareness and knowledge about adrenal hemorrhage.
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PMID:Rivaroxaban Related Bilateral Adrenal Hemorrhage: A Rare Complications of Direct Oral Anticoagulants - A Case Reports. 3167 47