Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A male child, born at 37+5 gestational weeks (GWs) (birthweight 2000g) after intrauterine growth retardation (IUG; -3 SD), to a mother treated during pregnancy for asthma, developed periventricular leukomalacia and retinopathy with total retinal detachment in the left eye and partial detachment in the right eye. Apart from basic asthma treatment with terbutalin, budesonid, and fenoterolhydrobromid throughout the pregnancy, she was treated with intravenous or oral cortisone for 6.5 weeks from 28+5 GWs. In addition she developed deep venous thrombosis at 29 GWs and was treated with heparin until delivery. Psychotic symptoms during the 31st GW were treated with diazepam, haloperidol, and levomepromazin. Functional sequelae for the child were visual impairment (visual acuity 5/60), uneven intellectual profile (Wechsler Pre-school and Primary Scale of Intelligence, Verbal IQ 94 and Performance IQ 32 at 8y of age), and autistic-like behaviour. The possibility that pre- and perinatal risk factors (e.g. severe maternal illness, IUGR, and cortisone treatment) in a term infant may create conditions for developing eye and brain pathologies commonly closely related to preterm birth should be considered.
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PMID:Periventricular leukomalacia and retinopathy in a term infant born to a mother with asthma. 1654 19

About one-third of patients undergoing vitreoretinal surgery are receiving anticoagulation therapy. There are no consensus guidelines on anticoagulation in this setting. Sixty patients (mean age 73 y) on anticoagulation therapy underwent vitreoretinal surgery. The indications for anticoagulation included atrial fibrillation, coronary insufficiency, cerebrovascular disease, deep vein thrombosis and prosthetic heart valves. Twenty-two patients (36.7%) were treated with vitamin K antagonists and 38 (67.3%) with antiplatelet agents (clopridogel or aspirin). After sub-tenon anesthesia, the surgical procedure was performed as usual, regardless of preoperative treatment and intercurrent disease. One patient who underwent a major procedure for complicated retinal detachment had an intraoperative subretinal hemorrhage requiring retinectomy. No other complications occurred. These results suggest that no change in ongoing anticoagulation therapy is required for patients scheduled for vitreoretinal surgery.
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PMID:[Anticoagulation and vitreoretinal surgery]. 1822 42

In March 2014, a 56-year-old woman without previous underlying disease underwent encircling scleral buckling, 20-gauge pars plana vitrectomy, cryotherapy around a retinal tear, and gas-fluid exchange with 15% perfluoropropane flush for upper rhegmatogenous retinal detachment of the left eye. However, she developed progressive left leg swelling, pain, warmth, and redness, associated with difficulty in elevating her left leg after continuously maintaining a prone head position when either lying down or sitting for 2 days. When she arrived at the emergency room, she had an elevated D-dimer level. After undergoing Doppler ultrasound imaging, she was diagnosed as having deep vein thrombosis of the left leg. She received anticoagulation therapy with enoxaparin and warfarin overlapping for 7 days. The edema, pain, and paresthesia of her left leg were relieved. However, because of the risk of bleeding with anti-coagulation drug usage, the patient needed to be monitored for 6 months. Prone positioning for gas tamponade is important for anatomic and functional success in retinal detachment surgery; however, timely walking and rest between periods of continuous prone positioning should be encouraged to prevent deep vein thrombosis and other impaired circulation-related complications.
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PMID:Deep vein thrombosis due to continuous prone positioning after retinal detachment surgery. 2901 20