Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149871 (deep vein thrombosis)
 12,364 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Proteus syndrome is a rare and sporadic disorder that causes postnatal overgrowth of multiple tissues in a mosaic pattern. The overgrowth can involve skin, subcutaneous tissue, connective tissue (including bone), the central nervous system, and viscera. Complications of Proteus syndrome include, among others, progressive skeletal deformities, invasive lipomas, benign and malignant tumors, and deep venous thrombosis with pulmonary embolism. Care of patients with Proteus syndrome presents significant challenges to both physicians and parents because of the various medical as well as psychosocial consequences of the disease. Herein, the case of a 5-year-old patient who manifested a number of these complications is presented. Current knowledge about the diagnosis, natural history, etiology, and management of the disorder is reviewed.
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PMID:The multifaceted challenges of Proteus syndrome. 1132 26

There is a need for developing alternative safe, inexpensive and noninvasive methods for rapid and effective recanalization of thrombosed arteries and veins that can be commenced immediately upon admission to hospital, or even prior to admission. Transcutaneous delivery of low-frequency, high-intensity ultrasound has the potential to be used clinically in various types of thrombotically occluded blood vessels including acute myocardial infarction, strokes, ischemic limbs, obliteration of A-V fistulas of patients undergoing hemodialysis, retinal vein thrombosis, deep vein thrombosis, and even thrombotically stuck prosthetic heart valves. Thus far, various noninvasive ultrasound systems have been used in several animal models. These systems vary in the mode of ultrasound delivery (continuous versus pulse, diffuse versus concentrated or pulsed beam), frequency (between 20 kHz and 1 mHz), and intensity. In general, lower frequencies have better penetration through overlying tissue (skin, fat, bone) and, probably, better efficacy.
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PMID:Augmentation of reperfusion by noninvasive, transcutaneous delivery of low-frequency, high-intensity ultrasound. 1247 Mar 63

The study accrued 257 patients with mechanical traumas of varying severity and sites, complicated by post-traumatic phiebothrombosis. In 87 (33.85%) patients, traumatic disease was aggravated by pulmonary artery thromboembolism (PTE). In the course of the study we evaluated risk factors of PTE related to the patient's condition and trauma. It has been established as a result that of 14 recognized risk factors of PTB determined by the patient's condition, only six influenced this disease outcome, namely: age over 40 years, a history of PTE or deep venous thrombosis (DVT), overweight, circulatory and respiratory insufficiency, bed regime. Among risk factors of PTE linked with trauma, the following factors had a significant impact on the emergence of PTE: treatment by means of skeletal traction, the site of trauma in the lower extremity (femoral or tibial bone), the site of previous thrombosis in the deep veins of the leg and thigh as well as floating thrombus.
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PMID:[Pulmonary artery thromboembolism in patients with trauma]. 1647 96