Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149521 (chronic pancreatitis)
 7,199 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors examined antibodies against antigen of gastric parietal cells using the method of reaction of complement-binding and the immunofluorescence test in 662 patients. Concurrently they examined in 443 patients of this group also antibodies against thyroglobulin. The group comprised 312 men and 350 women. For statistical evaluation the chi 2 test was used. Antibodies against the antigen of parietal cells were positive at the level of significance p less than 0.05 in the group with other diseases, at the level of significance of p less than 0.01 in dyspeptic syndrome, and at the level of significance p less than 0.001 in hypothyroidism and in chronic hepatopathies. The immunofluorescence test was statistically significant at the level of p less than 0.01 only in duodenal ulceration, at the level of p less than 0.001 in dyspeptic syndrome, hypothyroidism, hyperthyroidism, chronic hepatopathies, chronic pancreatitis, cholecystopathies, nephropathies and in the group of other diseases. Thyroid antibodies were positive with titres of p less than 1: 50 in 5.63, with titres of p less than 1: 5000 in 3.03%. The mentioned disease have not only pathomorphological and aetiological similarities but there is also serological overlapping.
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PMID:[Antibodies against gastric parietal cells and thyroglobulin in various diseases in humans]. 163 92

Pancreatic adenocarcinoma (PA) patients often present high serum titres of several autoantibodies including autoantibodies against beta-islet cells and insulin. In the present study we examined with an hemagglutination method the sera of 33 patients with PA for the presence of both anti-mitochondrial and anti-thyroglobulin antithyroid autoantibodies (ATA). Twenty-six surgical patients with other non-malignant gastrointestinal tract (GI) disease (chronic pancreatitis or hernia) and 40 healthy volunteers were used as controls. Eight of the 33 PA patients were found to have ATA autoantibodies, whereas only one patient with chronic pancreatitis and 2 normal individuals had high serum ATA titres. The difference between the PA patients and either of the control groups was statistically significant (p < 0.05). The production of autoantibodies could be attributed to impaired immunoregulation caused by the malignant cells.
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PMID:Thyroid autoantibodies and thyroid function in patients with pancreatic adenocarcinoma. 909 Sep 69