Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0149521 (
chronic pancreatitis
)
7,199
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
YPEL1
is a nuclear protein that is suggested to be involved in mesenchymal to epithelial-like transition during tissue development. Recently we have identified
YPEL1
as a gene whose expression is deregulation in perineural invasive pancreatic cancer cells. In this study we assessed the expression of
YPEL1
in normal and diseased pancreatic tissues and pancreatic cancer cell lines. Quantitative real time polymerase chain reaction was used to analyze the expression of
YPEL1
mRNA in nine cultured pancreatic cancer cell lines and pancreatic bulk tissues of the normal pancreas (n=19),
chronic pancreatitis
(n=19) and pancreatic adenocarcinoma tissues (n=31). Quantitative real time polymerase chain reaction analysis revealed a significant down-regulation of
YPEL1
mRNA expression in pancreatic adenocarcinoma tissues compared to normal tissues (54.1+/-5.2 vs. 85.8+/-14.1 copies/10,000 copies cpb) and low expression of this gene indicated a tendency for better survival of pancreatic cancer patients (16 vs. 13 months; p=0.17). Expression of
YPEL1
mRNA was present in all tested pancreatic cancer cell lines with comparably low to moderate expression levels of 4.3 - 88.0 copies/10,000 copies cpb. Reduced expression of
YPEL1
in pancreatic cancer might be related to perineural invasion. and prognosis.
YPEL1
might be an important factor during the development and malignant transformation of tissues. Further studies are required to better assess the role of human
YPEL1
in pancreatic cancer pathogenesis.
...
PMID:Expression of YPEL1 in pancreatic cancer cell lines and tissues. 1989 29
