Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0149521 (
chronic pancreatitis
)
7,199
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Thrombotic thrombocytopenic purpura (
TTP
) constitutes a poorly understood multisystemic disease of vascular origin that may involve any organ by thrombotic occlusions of the small vessels. Treatment with plasmapheresis is the best therapeutic option at this present moment. Involvement of the pancreas is a well established feature of this disease, which has generally been interpreted as a consequence of pancreatic vascular compromise. However, there are a few cases in the literature in which the clinical signs of
TTP
developed well after the clinical and laboratory demonstration of acute pancreatitis (AP). Therefore, the possibility of pancreatic inflammation as a triggering factor of
TTP
may need to be considered. This cause-effect relationship between AP and
TTP
remains unclear. We report a patient with
chronic pancreatitis
presenting with two episodes of
TTP
, triggered by acute relapses of pancreatitis.
TTP
may, thus, constitute a hematological complication of AP. We discuss the pathophysiological aspects of this association, along with therapeutical options.
...
PMID:Acute pancreatitis as a triggering factor for thrombotic thrombocytopenic purpura. 982 Mar 99
Pancreatitis is a known complication of thrombotic
thrombocytopenic purpura
(
TTP
) found in approximately 2% of cases. The development of
TTP
as a clinical sequelae of acute pancreatitis has also been reported, including one patient with
chronic pancreatitis
who developed
TTP
on two occasions following acute exacerbations of pancreatitis. We describe a case in which multiple distinct episodes of
TTP
have followed the clinical and laboratory demonstration of acute pancreatitis in the same patient. Supportive care of the patient's pancreatitis and plasmapheresis in each case resulted in clinical improvement and resolution of
TTP
. While the pathophysiologic mechanism explaining this association remains unclear, the recurrence of
TTP
associated with the "rechallenge" of relapsing episodes of pancreatitis in our patient suggests that a cause-and-effect relationship does exist.
...
PMID:Recurrent thrombotic thrombocytopenic purpura (TTP) as a complication of acute relapsing pancreatitis. 1201 6
