Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149521 (chronic pancreatitis)
 7,199 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty-five patients with painful chronic pancreatitis underwent side-to-side pancreaticogastrostomy. Correct diagnosis was ensured by endoscopic retrograde cholangiopancreatography, decreased exocrine pancreatic secretion, abdominal calcifications, and histologic verification. A main etiologic factor was alcohol abuse (84 percent of patients). At a median follow-up period of 3.8 years, good, fair, and poor results were achieved in 56, 23, and 21 percent of patients, respectively. The operative mortality rate was 4.4 percent. At follow-up, 16 of the patients were employed, weight was increased by a mean of 2.5 kg, and the use of opiates was significantly reduced. Poor results were significantly related to preoperative use of tranquilizers and postoperative alcohol consumption. Neither patency of the anastomosis nor the time of observation were related to the operative result. The 8-year cumulative survival rate was 83 percent.
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PMID:Pancreaticogastrostomy for chronic pancreatitis. 291 37

On the basis of 18 preoperative variables obtained consecutively in 31 patients undergoing drainage operation for pain in chronic pancreatitis, a preoperative discriminant score for satisfactory/unsatisfactory result is set up. The patient most likely to be free of pain after the operation has no preoperative use of tranquilizers, no diabetes, little dilatation of the pancreatic duct, no small pseudocysts, but daily use of opiates. This is probably not a matter of causal connection but rather an expression of common underlying pathophysiological mechanism(s), somatic or psychological. A pocket chart for the practical use in the preoperative assessment index is designed.
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PMID:Prediction of outcome of pancreaticogastrostomy for pain in chronic pancreatitis. 358 2