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Query: UMLS:C0149521 (chronic pancreatitis)
 7,199 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 6 patients with chronic pancreatitis the exocrine function was inhibited by occlusion of the pancreatic exocrine ducts leading to atrophy of the glands. The function of the pancreatic islets remained intact. This procedure can be combined to advantage with partial resections. Preliminary clinical results are promising and in all cases pancreatic pains disappeared immediately after the operation.
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PMID:[Blocking of pancreatic exocrine function in the treatment of chronic pancreatitis (author's transl)]. 32 Nov 99

The authors have employed external drainage of the pancreatic duct in 96 patients. Pancreaticostomy was performed with prophylactic and therapeutic purposes. Prophylactic pancreaticostomy after the Doubilet technic was accomplished in all cases of papillosphincteroplasty. In case of evident stenosis of the pancreatic duct ostimum (6 patients) papillosphinctero-wirsungoplasty with external drainage of the duct was performed. In acute pancreatitis pancreaticostomy would contribute to prompt normalization of pancreatic enzymes and subsidence of the inflammatory process. In chronic pancreatitis with involvement of the duct system along with papillosphinctero-wirsungoplasty and transpapillary drainage of the pancreatic duct terminal portion also cystodigestive and pancreaticodigestive anastomoses were constructed with external transanastomosis transenteric (after the Folker technic) drainage of the cyst cavity of pancreatic duct.
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PMID:[Practical use of external drainage of the pancreatic duct]. 32 5

The serum content of immunoreactive insulin and growth hormone was determined during the intravenous glucose tolerance test in 104 patients suffering from chronic pancreatitis at the stage of exacerbation and of clinical remission. Reduction of glucose tolerance was more pronounced during the exacerbation of the disease than at the period of clinical remission. In comparison with the control group, insulin hypersecretion (more pronounced during the exacerbation) was revealed in these groups of patients as a whole. A reduction of the insulin/glucose ratio in the patients indicated a relative character of insulin deficiency. The maximal reduction of the insulin/glucose ratio was noted in the patients with a diabetic character of glucose tolerance. Elevation of the growth hormone basal secretion in comparison with control was revealed in the patients at the period of exacerbation.
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PMID:[Intravenous glucose tolerance test and insulin and growth hormone secretion in chronic pancreatitis]. 32 69

The diagnosis of both acute and chronic pancreatitis continues to be a challenge despite the development of new techniques and the refinement of old methods. The problem is best approached by the application of a combination of tests which can provide a reasonable degree of sensitivity and specificity applicable to the different forms of pancreatitis. In acute pancreatitis an elevation of serum amylase and amylase/creatinine clearance ratio is diagnostically useful. In chronic pancreatitis, several tests are needed to enhance the diagnostic yield, and such tests can include the secretin-pancreozymin test, ERCP, fecal fat measurement, Lundh test meal, and the administration of the synthetic peptide BZ-Ty-PABA.
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PMID:Laboratory aids in the diagnosis of pancreatitis. 34 Aug 13

Secretin (1 CU/Kg) plus Caerulein (100 ng/Kg) or Cholecystokinin (1 or 2 IvyU/Kg) were given by rapid intravenous injection (Schedule 1) or by continuous infusion (Schedule 2) to 63 control subjects (C) and 69 patients affected by chronic pancreatitis (CP). Duodenal juice was collected for two and four 30-minute periods in schedule 1 and schedule 2, respectively. Volume, bicarbonate, and enzyme content were measured. Secretin-Daerulein, by rapid intravenous injection, showed a strong overlapping between C and CP values and led to some side-effects. Secretin-Caerulein by continuous intravenous infusion gave almost identical results as the Secretin-Cholecystokinin.
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PMID:The role of caerulein in tests of exocrine pancreatic function. 34 11

The clearance of pancreatic and salivary amylase relative to creatinine was measured in 26 control subjects and 22 patients with chronic pancreatitis. Control values for pancreatic amylase clearance (+/- SD) were 2.64 +/- 0.86% compared with 1.54 +/- 0.95% for salivary amylase. In chronic pancreatitis, pancreatic amylase clearance ratios were significantly higher than controls (P less than 0.0005, mean 4.09 +/- 1.63 SD). The difference in clearance rate of salivary amylase did not reach a level of significance when compared with the control group. Twelve of the 22 patients showed pancreatic amylase clearance values above the normal limit of 4.4, while only five were abnormal when the clearance of total amylase was measured. The patients also showed statistically higher (P less than 0.0005) levels of serum salivary amylase when compared with 69 control sera. No such difference was found for the pancreatic component of serum amylase. Comparison of beta2-microglobulin clearance values showed no statistical difference between patients and controls.
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PMID:Pancreatic and salivary amylase/creatinine clearance ratios in normal subjects and in patients with chronic pancreatitis. 35 Jul 26

Immunoglobulins A, M and G in the pancreato-duodenal fluid (PDF) of 35 pancreatic disease-free individuals and 48 patients with chronic pancreatitis (25), hypersecretory disorders (10), renal transplanted (4) and with pancreatic cancer (9), were determined by a single radial immunodiffusion method. Although a trend of immunoglobulin hypersecretion in benign diseases and hyposecretion in malignancies was present, individual levels of Ig-A and Ig-M differed statistically only between cancer and other groups. Calculating the ratios of Ig-A to Ig-M (A/M) and Ig-A to total immunoglobulin contents (A/T) in the PDF of patients with chronic pancreatitis or cancer, however, a significantly higher or lower ratio, respectively, was found compared to control group. Differences in A/M ratios could not be detected between patients with benign diseases, but were constantly present when these patients were compared to pancreatic cancer. The underlying mechanism(s) of the disturbed immunosecretory system in pancreatic diseases remains speculative. Nevertheless, immunoglobulin measurements in the PDF of patients with pancreatic diseases offer a simple diagnostic aid in clinical differentiation of pancreatic pathology.
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PMID:The diagnostic significance of the immunoglobulin A to M and A to total ratios in the pancreatoduodenal fluid of patients with benign and malignant pancreatic diseases. 35 94

In Germany alcohol is responsible for 40--60 per cent of cases with chronic or chronic relapsing pancreatitis. The histologic lesions for a long time remain clinically asymptomatic. Their degree depends on the duration and the total amount of alcohol which is ingested. Promoters of alcoholic damage to the pancraes are a high intake of fat and protein and a genetic disposition. Acute application of alcohol leads to an inhibition of pancreatic secretion when the entrance of gastric acid into the duodenum is prevented. Otherwise a weak stimulation occurs with release of secretin. Chronic application of alcohol after a few months abolishes the initially seen inhibition and leads to an increase of enzyme secretion of the gland. The raised concentration of protein in the pancreatic juice is the cause of precipitation of protein plugs, and thus probably leads to the alterations which are typical for chronic pancreatitis.
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PMID:[Effect of alcohol on the human and animal pancreas (author's transl)]. 35 68

Total ligation of the pancreatic ducts of a normal gland in dogs and man results in atrophy of the acinar cells with preservation of islet cell function. Theoretically, this might be applied in the therapy of chronic pancreatitis since, in effect, an exocrine pancreatectomy results. Sustained islet cell function, as evidenced by a normal glucose tolerance test, following pancreatic duct ligation, was demonstrated in dogs for periods of up to two years. Resection of the head of the pancreas and ligation of the distal gland in six patients with chronic pancreatitis and an abnormal glucose tolerance test resulted in the development of insulin-dependent diabetes in all instances. Insulin-dependent diabetes was also demonstrated in one patient with a normal preoperative glucose tolerance test. Recurrent pancreatitis developed in only one patient. The study suggests that pancreatic duct ligation is effective in treating chronic pancreatitis but casts considerable doubt on the effectiveness of this procedure in preventing the development of diabetes, if the glucose tolerance test is abnormal
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PMID:Pancreatic duct ligation in the therapy of chronic pancreatitis. 38 Apr 23

Plasma insulin, pancreatic glucagon and immunoreactive glucagon-like polypeptide of intestinal origin (enteroglucagon) have been measured in 10 patients with chronic pancreatitis and 5 normal subjects. Basal levels and changes following oral glucose (50 g) and an intravenous infusion of arginine (25 g in 30 min) have been studied. In patients with chronic pancreatitis the plasma insulin response to oral glucose and intravenous arginine was reduced. Basal pancreatic glucagon was increased in the patients and increased further with oral glucose. During an arginine infusion the pancreatic glucagon showed a brisk early increase greater than that seen in the normal subjects. Basal enteroglucagon levels were significantly increased in chronic pancreatitis but response to orla glucose and arginine infusion were little different from those seen in the normal subjects.
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PMID:Glucagon secretion in chronic pancreatitis. 38 67


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