Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0149520 (acute cholecystitis)
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Human Gene/Protein
PLCE 10.9
LAMS 9.3
IDA 8.1
ELC 7.6
LCE 7.0
CBD 6.6
AdipoQ 6.2
MUC3 6.1
NPO 6.1
API2 5.9
RPC 5.8
ABCB4 5.8
pT3 5.5
ABCG8 5.4
ASA 5.4
Factor XII 5.4
TCB 5.3
JAM 5.3
AWS 5.2
BCL10 5.2
MUM1 5.1
CLC 5.1
white cell 5.1
EPG 4.9
PFK 4.8
pancreatic secretory trypsin inhibitor 4.8
MUC5B 4.6
P63 4.6
histamine H2 receptor 4.6
ESP 4.6
renal) 4.6
SAPS 4.5
MALT1 4.5
GSA 4.5
GIST 4.5
AEC 4.5
MUC4 4.5
MIB1 4.5
GEM 4.4
MUC6 4.4
F18 4.4
thyroid transcription factor-1 4.4
SIL 4.3
arylsulfatase A 4.2
complement protein 4.2
LEC 4.2
HC1 4.2
cholecystokinin 4.1
TPN 3.9
TRAM 3.9
GPT 3.8
TACE 3.8
xanthine dehydrogenase 3.8
ACG 3.8
EST) 3.7
LPC 3.7
EFS 3.7
version 1 3.6
She 3.6
S100A9 3.6
CD10 3.6
gamma-glutamyltransferase 3.6
cytokeratin 7 3.6
CDX2 3.5
alpha 1-antitrypsin 3.5
SMD 3.4
CYP7A1 3.4
C-reactive protein 3.4
factor XII 3.4
INF 3.4
BCL6 3.3
CD47 3.3
CLL 3.3
version 3 3.3
S100A8 3.2
caldesmon 3.2
CCK 3.2
MUC2 3.2
haptoglobin 3.2
PTC 3.2
MUC1 3.2
antichymotrypsin 3.2
CRP 3.2
ACR 3.1
CD43 3.1
DES 3.1
MUC5AC 3.1
interleukin 1 beta 3.1
visfatin 3.1
ADC 3.0
Leu5 3.0
HPA 3.0
DSS 3.0
MTHFR 3.0
ISS 2.9
chromogranin A 2.9
reserved 2.9
BID 2.8
AE3 2.8
thyroid peroxidase 2.8
GSD 2.7
alkaline phosphatase 2.7
CD15 2.7
NHL 2.6
S100 2.5
IVA 2.5
amylase 2.5
synaptophysin 2.5
CK20 2.5
AII 2.4
ara 2.4
PGD2 2.4
CD5 2.4
SAGE 2.4
MDS 2.4
Genesis 2.4
COX-1 2.3
alanine aminotransferase 2.3
troponin I 2.3
EPI 2.3
CD23 2.3
AE1 2.3
CDS 2.2
aspartate aminotransferase 2.2
CPR 2.2
E.coli 2.2
interleukin 6 2.1
CRH 2.1
carcinoembryonic antigen 2.0
tie 2.0
PSS 1.9
TdT 1.9
MOF 1.9
AFP 1.9
IVF 1.8
FEV 1.8
MRC 1.8
neutral endopeptidase 1.7
LDH 1.7
SBP 1.7
enolase 1.7
transthyretin 1.7
EST 1.6
ESR 1.6
vasoactive intestinal peptide (VIP) 1.6
non-Hodgkin's lymphoma 1.6
AML 1.6
alpha-fetoprotein 1.6
mucin 1.6
Ki-67 1.5
Men 1.5
non-functional 1.5
myeloperoxidase 1.5
Nei 1.5
ALP 1.4
xanthine oxidase 1.4
somatostatin 1.4
ICD 1.4
chronic renal failure 1.3
API 1.3
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Disease
Subhepatic abscess 13.5
acute cholecystitis 13.5
Pericholecystic abscess 12.9
Emphysematous cholecystitis 12.6
Acute gangrenous cholecystitis 12.5
Courvoisier's gallbladder 12.5
Duodenocutaneous fistula 12.5
Gangrenous cholecystitis 12.4
recurrent cholecystitis 12.2
Acute emphysematous cholecystitis 11.9
gallbladder empyema 11.8
Acalculous cholecystitis 11.5
gallbladder gangrene 11.5
chronic cholecystitis 11.4
biliary colic 11.2
Biliary colic 11.2
Calculous cholecystitis 11.2
Acute acalculous cholecystitis 11.1
gallbladder neoplasm 11.0
cholecystitis 10.9
recurrent gallbladder cancer 10.9
periproctitis 10.9
intrahepatic gallbladder 10.8
head neoplasm 10.7
Biliary ascariasis 10.7
Xanthogranulomatous cholecystitis 10.5
Oriental cholangiohepatitis 10.2
visceroptosis 10.2
Acute cholangitis 10.2
omentitis 10.2
alcoholic gastritis 10.0
Streptococcus bovis infection 10.0
Biliary disease 10.0
squamous cell carcinoma of the gallbladder 10.0
Biliary sludge 10.0
choledocholithiasis 10.0
postvagotomy syndrome 9.8
biliary tract disease 9.8
cholecystolithiasis 9.7
cholesterolosis 9.7
Biliary tract infection 9.7
Ascaridiasis 9.6
Mirizzi syndrome 9.6
Intra-abdominal abscess 9.5
Biliary dyskinesia 9.4
gallstones 9.3
Rokitansky-Aschoff sinuses 9.3
Febrile illness 9.2
Gallbladder disease 9.1
AIDS cholangiopathy 9.1
Bile peritonitis 9.0
Epiploic appendagitis 9.0
Alkaline reflux gastritis 9.0
gallbladder polyp 8.9
Omental torsion 8.8
postcholecystectomy syndrome 8.7
Bile duct cancer 8.7
perihepatitis 8.6
cholangitis 8.6
Fitz-Hugh-Curtis syndrome 8.5
Serratia infections 8.5
gallbladder cancer 8.4
Hemobilia 8.2
acute appendicitis 8.2
narcotic dependence 8.2
Acute hepatitis A 8.2
perforated duodenal ulcer 8.1
Diabetic gastroparesis 8.0
intestinal neoplasm 8.0
colonic diverticulitis 8.0
Duodenogastric reflux 8.0
biliary obstruction 7.9
strangulated hernia 7.9
Acute diverticulitis 7.9
Intrahepatic cholestasis 7.9
Gallbladder carcinoma 7.8
muscle neoplasm 7.8
Tako-Tsubo cardiomyopathy 7.8
subphrenic abscess 7.7
lobular breast carcinoma 7.7
ascariasis 7.6
colon neoplasm 7.6
obstructive jaundice 7.6
adenocarcinoma of the gallbladder 7.6
Neutropenic enterocolitis 7.5
Emphysematous gastritis 7.5
Ascaris lumbricoides infection 7.4
Waterhouse-Friderichsen syndrome 7.4
Gallstone ileus 7.4
pancreatitis 7.3
paralytic ileus 7.3
empyema 7.3
gangrene 7.2
epithelial mesothelioma 7.2
sickle cell crisis 7.2
bile duct stenosis 7.1
omphalitis 7.1
acute pancreatitis 7.0
Hyperamylasemia 6.9
liver abscess 6.9
global aphasia 6.9
diverticulitis 6.8
appendicitis 6.8
infectious enteritis 6.7
adnexitis 6.6
head cancer 6.6
breast cancer stage 6.6
pylephlebitis 6.5
heavy chain disease 6.5
ureterolithiasis 6.5
recurrent melanoma 6.4
Postoperative infection 6.3
Primary liver cancer 6.3
Hemodynamic instability 6.3
ileus 6.3
hepatic adenoma 6.3
Invasive candidiasis 6.3
peritonitis 6.3
angioendotheliomatosis 6.2
VES 6.1
biliary tract cancer 6.1
mesenteric thrombosis 6.1
Clostridium difficile colitis 6.1
volvulus 6.1
biventricular failure 6.0
scrub typhus 5.9
RPC 5.8
Small intestine 5.8
perianal abscess 5.8
congenital hemolytic anemia 5.7
acute salpingitis 5.7
cholestasis 5.7
splenic infarction 5.7
bowel obstruction 5.7
acute alcoholic hepatitis 5.7
linitis plastica 5.7
Klatskin 5.7
Pneumoperitoneum 5.6
ischemic colitis 5.6
acute pericarditis 5.6
B-cell neoplasm 5.6
Laennec 5.6
Carcinosarcoma 5.6
hypoprothrombinemia 5.5
acute disease 5.5
drug-induced hepatitis 5.5
primary disorders 5.5
morbid obesity 5.4
actinomycosis 5.4
Peripartum cardiomyopathy 5.4
acute cystitis 5.4
Upper gastrointestinal bleeding 5.3
Richter's syndrome 5.3
neonatal jaundice 5.3
Munchausen syndrome 5.3
pyonephrosis 5.2
papillitis 5.2
pancreatic abscess 5.2
Caroli's disease 5.2
infectious hepatitis 5.1
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Symptom
Murphy's sign 12.3
peritoneal pain 11.2
liver pain 10.5
decreased bowel sounds 10.0
right upper quadrant pain 10.0
musculoskeletal chest pain 9.5
localized abdominal pain 9.3
Pneumobilia 8.8
Pain and tenderness 8.4
acute abdominal pain 7.8
acute abdomen 7.6
iliac fossa pain 7.2
generalized abdominal pain 6.9
epigastric pain 6.6
left upper quadrant pain 6.4
dark urine 6.3
abdominal pain 6.1
colic 6.0
renal colic 5.8
asterixis 5.8
Multimorbidity 5.6
rigors 5.4
lassitude 5.3
right lower quadrant pain 5.2
No adverse effect 5.2
abdominal discomfort 5.1
fever of unknown origin 5.0
abdominal fullness 4.8
belching 4.8
stomach pain 4.5
hyperemesis gravidarum 4.4
acute pain 4.3
night sweats 4.3
nausea 4.2
nausea and vomiting 4.0
groin pain 3.9
intestinal bleeding 3.8
consciousness disturbance 3.8
bloating 3.8
chills 3.7
vomiting 3.6
tense 3.4
decreased appetite 3.3
asthenia 3.1
anorexia 3.1
pain 3.0
shoulder pain 3.0
hepatomegaly 3.0
back pain 2.9
analgesia 2.7
anesthesia 2.7
discomfort 2.6
splenomegaly 2.5
hemiplegia 2.5
discomfort 2.5
heartburn 2.4
flank pain 2.4
stridor 2.3
dysuria 2.2
chest pain 2.2
spasm 2.2
pallor 2.2
tachypnea 2.2
constipation 2.2
Wind 2.1
hypercapnia 2.1
sore throat 2.1
respiratory distress 2.0
knee pain 2.0
cachexia 2.0
hemoptysis 1.9
flushing 1.8
myalgia 1.8
diarrhea 1.8
dyspnea 1.7
dysarthria 1.6
syncope 1.3
wheezing 1.3
low back pain 1.2
numbness 1.1
shortness of breath 1.1
Ill 1.0
paresis 1.0
hypotonia 1.0
fatigue 0.8
arthralgia 0.7
weakness 0.6
cough 0.5
angina 0.1
thinning 0.0
starvation -0.1
sleepiness -0.2
functional recovery -0.2
headache -0.3
overweight -1.2
collapse -1.3
seizures -2.8
Drug
Iprofenin 13.5
Sincalide 9.0
Gadobenate dimeglumine 8.4
Morphine sulfate 8.2
Lariam 8.0
Lariam 7.7
Temocillin 7.5
Rocephin 7.3
Gd-BOPTA 6.7
Dimethylformamide 6.5
Plavix 6.5
CTRX 6.4
Indocyanine green 6.4
Rocuronium 6.3
Surgicel 6.3
Ertapenem 6.1
Enfuvirtide 6.0
Voltaren 5.5
Piperacillin 5.5
Cellulose acetate 5.4
Eculizumab 5.0
Dalteparin 5.0
Zinat 4.9
Diclofenac sodium 4.7
Liraglutide 4.7
Gastro 4.7
PFT 4.5
Levonorgestrel 4.4
Everolimus 4.0
AGG 3.9
Cetuximab 3.6
PFA 3.5
Clopidogrel 3.4
Infliximab 3.3
Infliximab 3.3
AMC 3.3
Hypaque 3.2
Fluconazole 3.1
ampicillin 2.8
CPR 2.8
PTC 2.7
Norplant 2.7
Indomethacin 2.4
EPI 2.4
MDS 2.4
Estrogens 2.3
nitroglycerin 1.9
MOF 1.9
AZT 1.9
MRC 1.7
Portal 1.4
G-CSF 1.1
Histamine 1.0
CTX 1.0
CTX 1.0
Bifidobacterium 1.0
ROC 0.6
EE2 0.6
Spectrum 0.5
ENT 0.4
ABC 0.4
CTX 0.2
Dial -0.4
MAP -0.5
lactose -0.5
Cardiovasc -0.7
caffeine -0.9
Monit -1.6
Dermatol -2.9
Enzyme
PMT 4.8
prostaglandin synthetase 4.2
arylsulfatase A 4.2
TACE 3.8
Rex 3.6
CYP7A1 3.5
xanthine dehydrogenase 3.2
alkaline phosphatase 2.7
TdT 2.6
alanine aminotransferase 2.4
CD10 2.2
aspartate aminotransferase 1.9
thyroid peroxidase 1.9
sulfatase 1.8
enolase 1.6
phosphofructokinase 1.6
xanthine oxidase 1.4
beta-lactamase 1.4
gamma-glutamyl transpeptidase 1.3
adenosine deaminase 1.2
adenosine deaminase 1.1
CPR 1.1
acid phosphatase 0.8
urease 0.7
urease 0.6
beta-glucuronidase 0.6
catalase 0.3
peroxidase -0.2
collagenase -0.7
lipase -0.7
phosphodiesterase -0.7
creatine kinase -0.7
trypsin -0.9
lysozyme -0.9
superoxide dismutase -1.4
reverse transcriptase -1.5
luciferase -1.7
focal adhesion kinase -1.9
ACS -2.8
ERK -3.1
Compound
Aspoxicillin 9.8
Morphine sulfate 8.4
Pyrantel 8.4
Pyrantel pamoate 8.3
Cefmetazole 8.1
IDA 8.0
ethyl propionate 7.1
PGB2 7.0
Cephaloridine 7.0
Lincomycin 6.8
Lincomycin 6.7
5-methyltryptophan 6.6
Rocuronium 6.4
Diisopropyl 6.4
A101 6.4
Lomefloxacin 6.3
Cefuroxime 6.3
Ceftriaxone 6.2
Ajmaline 6.2
Histoacryl 6.1
EDAP 6.0
Levonorgestrel 5.7
Piperacillin 5.5
PALA 5.4
Cystathionine 5.3
Cystathionine 5.3
Loperamide 5.2
Cefepime 5.1
Meperidine 5.1
ANI 5.0
Aztreonam 5.0
Fosfomycin 5.0
A 71 4.9
TBE 4.9
PMT 4.8
Kanamycin 4.7
DHF 4.6
MPT 4.5
Ursodeoxycholic acid 4.2
Morphine 4.1
Albendazole 4.1
ASA 4.1
Cystine 4.1
Amikacin 3.9
GPT 3.8
TACE 3.8
Bismuth 3.6
A 42 3.5
Lewis X 3.3
Bilirubin 3.2
Hypaque 3.1
Lip 3.0
DES 3.0
LIN 3.0
Interleukin-2 3.0
Tetracycline 2.8
LPC 2.7
BRL 2.7
CCC 2.6
Indomethacin 2.6
CCC 2.6
Luminal 2.6
Gentamicin 2.6
PGD2 2.6
Prostaglandin 2.6
Prostaglandin 2.6
Glutamine 2.5
TCM 2.5
TCM 2.5
Parenteral 2.2
DSS 2.2
Malondialdehyde 2.1
barium 2.1
Methicillin 1.9
A 1 1.8
Melatonin 1.8
DTPA 1.7
6-12 1.7
Congo red 1.6
ALP 1.4
PGE 1.4
ACh 1.3
GAL 1.3
Cholesterol 1.2
oxalate 1.2
GSSG 1.0
Histamine 1.0
Optimal 1.0
homocysteine 1.0
diacetate 0.9
Clin 0.8
His 0.8
Isoproterenol 0.7
Lactate 0.7
prostacyclin 0.7
NIDA 0.7
Hemoglobin 0.7
PGE2 0.7
prostaglandin E1 0.6
H2S 0.6
TNM 0.5
Progesterone 0.4
DMF 0.4
CAT 0.3
CAT 0.3
chloroform 0.3
Sodium 0.3
Estrogen 0.3
CAT 0.2
CTX 0.2
MIC 0.1
N-acetylcysteine 0.1
salicylic acid 0.0
NADP 0.0
CO2 0.0
sulfate -0.1
Dec -0.2
urea -0.2
phenol -0.2
glutamine -0.2
xylose -0.4
TSH -0.4
Dial -0.5
salt -0.5
iodine -0.5
fluorine -0.6
ACTH -0.8
creatinine -0.8
Ile -0.9
GSH -0.9
GSH -0.9
caffeine -0.9
calcium -1.1
nitric oxide -1.1
hydroxide -1.1
EDTA -1.2
EDTA -1.2
Insulin -1.3
aluminum -1.3
carbonate -1.4
H2O2 -1.4
sodium -1.4
Pac -1.6
manganese -1.6
tryptophan -1.6
tryptophan -1.6
phosphate -1.6
tryptophan -1.7
glutamate -1.7
glucose -1.7
PEG -1.8
Cardiol -1.8
tryptophan -1.9
potassium -2.1
Phe -2.2
nitrogen -2.2
PEG -2.3
water -2.3
methionine -2.4
silver -2.4
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