Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149520 (acute cholecystitis)
 2,784 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The perioperative changes in epinephrin-, norepinephrine-, histamin-, C5a- and interleukin-6-levels were studied in 40 patients undergoing cholecystectomy for the diagnosis of acute cholecystitis. All relevant mediator levels could be determined in 38 patients. The outcome was not optimal in 16 of them (42%). In order to evaluate the predictive value of the mediators under investigation for the quality of the patients' outcome, a model based on the Bayes' theorem was developed. Using this model the outcome (optimal vs. not optimal) could be correctly predicted in 30 (79%) of our study patients. This kind of data analysis allows to define states of increased risk for a not optimal recovery based on biochemical parameters.
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PMID:[Prediction of rehabilitation outcome after surgical interventions based on biochemical parameters: a new concept in mediator research]. 1451 7

At examination of 160 patients with acute cholecystitis (ACH) it was stated that on 1st-2nd day after cholecystectomy the patients with complicated course of ACH have had a real increase of levels of interleukin-6, tumor necrosis factor-alpha, homocysteine, metabolites of nitric oxide, indexes of cytopathic hypoxia (hypoxanthine and xanthine, activity of adenosine deaminase, xanthine oxidase and xanthine dehydrogenase). These alterations were the most significant and lingering at the patients who has postoperative complications. Addition of levels of proinflammatory cytokines was over 50% and of indexes of cytopathic hypoxia--over 30-40% on the 1st-2nd day after operation what makes it possible to prognose the postoperative pyoinflammatory complications appearance at more that 60% of patients and to forecast favourable course of postoperative period with reliability over 90%--for its absence.
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PMID:[Dynamics of the cytokines, homocysteine contents, indices of oxydative and nitrosative stress and cytopathic hypoxia in patients after cholecystectomy for acute cholecystitis. Connection with rate of postoperative purulent-inflammatory complications]. 1562 40