Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0149520 (
acute cholecystitis
)
2,784
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The purpose of this study was to describe the outcome of patients undergoing surgery with recognized and unrecognized
factor VIII
inhibitor. The setting was a tertiary care center with a community-based general surgery training program. Two patients with acquired
factor VIII
inhibitor coagulopathy required cholecystectomy. Interventions included intravenous immunoglobulin (IVIG) and
factor VIII
transfusions. An elderly patient undergoing urgent open cholecystectomy for
acute cholecystitis
exsanguinated despite postoperative recognition and treatment of
factor VIII
inhibitor. A second patient with known
factor VIII
inhibitor underwent laparoscopic cholecystectomy with perioperative transfusions of
factor VIII
and IVIG. No hemorrhage occurred, but cost to the patient exceeded 50,000 dollars. Acquired
factor VIII
inhibitor coagulopathy is rare and potentially lethal. Preoperative recognition and appropriate hematologic intervention is crucial to achieve a successful outcome.
...
PMID:Cholecystectomy and acquired factor VIII inhibitor coagulopathy. 1548 1
