Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149520 (acute cholecystitis)
 2,784 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aseptic inflammation in the gallbladder wall was studied in vitro using rabbit gallbladders. Wall permeability changes, measured as changes in the transmural passage of radioactively labelled hippuran and biligraphin as well as enzyme (acid phosphatase) release from wall to lumen were registered as parameters permitting quantitative assessment of an inflammatory process. Lysolecithin, a surface-active substance of possible significance in the pathogenesis of acute cholecystitis was chosen as inflammation-inducing agent. When 6-20 mg/ml lysolecithin was instilled into the gallbladders, dose-dependent increases in permeability and enzyme release occurred. No effects as compared with controls were seen when 2 mg/ml was instilled. Lysolecithin-treated gallbladders showed morphological signs of inflammation as opposed to untreated. The data reported are consistent with earlier observations that lysolecithin may cause inflammatory lesions to the gallbladder wall. The experimental model used may prove useful in examining the effects of aggressive and protective agents upon the gallbladder mucous membrane.
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PMID:Lysolecithin-mediated inflammatory reaction in rabbit gallbladder. Permeability increase and enzyme liberation. 118 3

Functional condition of basic components of the microbicidal system (cation protein myeloperoxidase, acid phosphatase) and spontaneous NB-test of neutrophylic leukocytes' activity values were studied with the aid of cytochemical methods in 175 patients: with acute cholecystitis (133) and exacerbation of chronic one (42). As a result of performed examinations various changes of intraleukocytic components and activity of spontaneous HB-test, of neutrophils were established, which depended on phase, severity of the disease and morphological changes and manifestations of pathological process. The determined changes of intracellular components and activity of spontaneous HB-test values of leukocytes in patients with acute and chronic cholecystitis demonstrate the tension of nonspecific reactivity of the organism.
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PMID:[Functional-metabolic activity of leukocytes in patients with cholecystitis]. 1021 51