Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gicerin is a novel cell adhesion protein that belongs to the immunoglobulin superfamily. Gicerin protein adheres to neurite outgrowth factor, an extracellular matrix protein in the laminin family, and also exhibits homophilic adhesion. In the present study, we investigated the involvement of gicerin and neurite outgrowth factor in tracheal development and regeneration. In an early embryonic stage, gicerin protein was highly expressed in tracheal epithelial cells, but not in loosely arranged mesenchymal cells. During development, mesenchymal cells become condensed around the tracheal epithelium and then differentiate into muscle and cartilage; high levels of gicerin expression were observed in these cells. In the later embryonic and posthatching stages, no gicerin expression was detected in tracheal epithelium or cartilage. In addition, expression of gicerin increased transiently in the tracheal epithelium during the regeneration after tracheitis induced by the infectious bronchitis virus. Furthermore, a polyclonal antibody against gicerin inhibited the epithelial regeneration in tracheal organ cultures. These findings suggest that glcerin plays an important role in both tracheal development and regeneration.
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PMID:Involvement of gicerin, a cell adhesion molecule, in tracheal development and regeneration. 895 45

Gicerin is a novel cell adhesion molecule belonging to the immunoglobulin super-family. In this study, we examined the relationship between the expression of gicerin, and the regenerating process of collecting ducts and ureters of chickens with interstitial nephritis caused by a nephrotropic strain of infectious bronchitis virus (IBV). Immunohistochemical analysis showed that gicerin expression was found on the epithelial cells of collecting ducts and ureters in the embryonic kidneys, but was undetected in these regions following hatching. In the IBV-infected kidneys, gicerin was undetected in the degenerative epithelia of collecting ducts and ureters during the acute stage of infection, but became strongly re-expressed in these regions in the regenerating stage, and gicerin expression then became undetectable in the completely repaired epithelia. These findings suggest that gicerin expression is strictly regulated for use in the epithelial regeneration, as well as development of collecting ducts and ureters of chicken.
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PMID:The expression of gicerin, a cell adhesion molecule, in regenerating process of collecting ducts and ureters of the chicken kidney following infection with a nephrotropic strain of infectious bronchitis virus. 1848 5