Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The concentrations of three known elastase inhibitors (alpha 1 proteinase inhibitor, antileucoprotease, and alpha 2 macroglobulin) have been determined in the sputum of six patients with obstructive bronchitis over five consecutive days. Antileucoprotease was the major inhibitor measured and potentially could provide more than 80% of the elastase inhibition, whereas the contribution of alpha 2 macroglobulin was less than 0.2%. Comparison with the inhibitory capacity of the secretions active against human neutrophil elastase showed that the inhibitors could account for only about half of the inhibition measured. This suggests the presence of a substantial amount of unrecognised inhibitor. Corticosteroid treatment in 10 patients reduced the mean alpha 1 proteinase inhibitor concentration (p less than 0.025) from 18.6 micrograms/ml (SD 22.5) to 9.8 (6.6). Antileucoprotease, however, increased (p less than 0.05) from 20.5 micrograms/ml (24.3) to 39.3 (23.4). These changes were associated with an increase in elastase inhibition (p less than 0.025) from 180 (160) micrograms elastase/ml secretion to 310 (130), suggesting a beneficial effect of steroid treatment on the antielastases in lung secretions.
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PMID:Elastase inhibitors of sputum sol phase: variability, relationship to neutrophil elastase inhibition, and effect of corticosteroid treatment. 243 94

When examined for immunological status, complement, basic endogenic protease blockers parameters, patients with infiltrative destructive tuberculosis of the lungs (IDTL) and IDTL combination with exacerbation of chronic pyo-inflammatory bronchitis, exhibited disturbances in cellular and humoral immunity, complement activity, content of alpha 1 protease inhibitor and alpha 2 macroglobulin which aggravated in combined respiratory pathology. Nonspecific aerosol treatment with native protease inhibitors (contrykal or gordox) and thymalin aroused the efficacy of etiotropic treatment and promoted normalization of the above defense systems.
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PMID:[Immunological and nonspecific reactivity in patients with infiltrative pulmonary tuberculosis associated with chronic nonspecific lung diseases]. 756 59