Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

8 normals, 8 asthmatics and 8 bronchitics inhaled comparable doses of ipratropin and salbutamol. Five different flow-volume parameters were measured before and at intervals from 3 to 360 minutes after inhalation, on a total number of 2880 maximal effort expiratory flow-volume curves. Arterial blood gas tensions were measured before and 60 minutes after inhalation. In all parameters a significant larger effect (p less than 0.05) of ipratropin was found in normals, but in different time intervals. The parameter FEV1 and MEF at 50% of FVC showed the largest effect of salbutamol during the interval from 3 to 60 minutes in the asthma patients. None of the parameters showed significant difference in drug effects in the bronchitis patients. The findings suggested a more peripheral action of ipratropin than of salbutamol in the normals. No significant change in gas tensions were found after inhalation in any of the three groups.
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PMID:A double blind cross-over study of maximal expiratory flows and arterial blood gas tensions in normals, asthmatics and bronchitics after salbutamol and ipratropin. 15 94

Maximal mid-expiratory flow (MMEF), maximal expiratory flow volume (MEFV) curves obtained with a wedge spirometer, and nitrogen closing volumes were determined in 38 patients with mild airway obstruction. Seventeen patients had asthma in remission and 21 had bronchitis. In all of them the forced expiratory volume in one second was within the normal range. Results were compared with predicted data in the literature and with a group of normal control subjects. In the patients with asthma, compared to predicted flow rates, MMEF was abnormal in 5, MEFV curves were abnormal in at least 8; closing volume was abnormally increased in only one patient, and an abnormal slope of the alveolar plateau was present in 4 additional patients. In the patients with bronchitis, compared to predicted flow rates, -MEF was reduced in 5, MEFV curves were abnormal in at least 7; increased closing volumes were present in 6, and the slope of the alveolar plateau was abnormal in 3 other patients. When flow rates were compared with those of normal control subjects, MMEF was about as frequently abnormal as MEFV curves, suggesting that the discrepancy between abnormal MMEF AND MEFV curves was due to variability of the predicted data. The results indicated that flow rates can be abnormal in subjects with normal closing volumes and a normal slope of the alveolar plateau, and that MEFV curves can be more sensitive than closing volume in detecting abnormalities in patients with mild airway obstruction. The results suggested that the use of both MEFV curves and the closing volume test for screening would defect functional abnormalities more frequently than either test alone.
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PMID:Comparison of maximal mid-expiratory flow, flow volume curves, and nitrogen closing volumes in patients with mild airway obstruction. 112 86

A double blind vs placebo study was carried out to study the effect of letosteine on the symptoms and clinical course of paediatric patients suffering from acute febrile bronchitis. Forty children were recruited for the research: 20 were treated with letosteine in a dose of 25 mg x 3 g/die and 20 with placebo; treatment lasted 10 days. The following parameters were assessed during the trial: body temperature, cough, thoracic objectivity, respiratory function indices. The results of the study show that in the letosteine treated group there is a statistically significant decrease in fever, a favourable evolution of thoracic objectivity and an improvement in certain respiratory function parameters (MEF 75, PEF). It is concluded that treatment with letosteine leads to a significant increase in the rate of regression of thoracic symptomatology and a faster, more substantial reduction in fever in children suffering from acute bronchitis. This is probably the result of drug action on mucus viscosity, restoring optimal mucociliary clearance, and through action fostering the penetration of antibacterial substances into the mucus.
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PMID:[Clinical evaluation of letosteine activity in the treatment of acute febrile bronchitis in children. Double-blind controlled study versus placebo]. 269 29

In a 3-year follow-up we have investigated random samples of young men (initial age 20 to 24 years) by means of the modified BMRC questionnaire and maximal expiratory flow-volume curves. The participation in the second survey was relatively poor (51.9 p.c.). The lung function data of asymptomatic non-smokers were in good accordance with reference values of other authors. We found significant differences between smokers and non-smokers already in this age group. There was no correlation with the extent of smoking. Cessation of smoking resulted in improved ventilatory data, especially MEF 50. We found no close relation between bronchitis symptoms and ventilatory disturbances in these young men. Wheezing correlated better with lung function impairment. In young male adults the flow-volume curve seems to be somewhat more sensitive than conventional spirometry in contrast to the results in elder subjects.
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PMID:[Value of the maximal expiratory flow-volume diagram in a longitudinal study. 2. Results in young adults]. 376 18

In a 4-year follow-up we have measured the maximal expiratory flow-volume curve in a random sample of the population of a hydrogen chloride air-polluted area. At the first investigation the pressure transducer of our pneumotachograph had shown an unsatisfactory frequency characteristic. Therefore the initial flow of the flow-volume curve (PEF and MEF 75) were underestimated. The values for asymptomatic non-smokers of the restudy were in good accordance with reference values of other authors. On both occasions we found significant differences between smokers and non-smokers and between persons with and without bronchitis. The lung function data correlated also with tobacco consumption. There was no evidence for superiority of the maximal expiratory flow rates over the conventional spirometric parameters FEV1 and FVC.
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PMID:[Value of the maximal expiratory flow-volume diagram in a longitudinal study]. 408 57

The diagnostic value of different respiratory function tests in the respiratory distress syndrome was compared in 5 groups of subjects: healthy non-smokers, asymptomatic smokers, patients with bronchitis affecting the large bronchi, asthmatic patients between attacks, and patients with emphysema. Indices measured were the forced expiratory volume per second (FEV1), mean expiratory flow between 25 and 75% of vital capacity (MEF 25-75%), maximum instantaneous flow at 25-50-75% of vital capacity, and peak flow (Vmax 25-50-75%, PF), residual volume, expiratory resistance volume, and the curve of the alveolar plateau of expired nitrogen. The Vmax 50% and the MEF 25-75% appear to be sufficiently sensitive indices of bronchial obstruction in current practice, the MEF 25-75% being simple to measure, and presenting the advantage of not requiring complicated equipment. The Vmax 25% and the respiratory resistance volume present wide inter-individual variations, and this, together with their lack of reproducibility, limit their value in exploratory tests in isolated cases.
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PMID:[Comparative value of different respiratory function tests for the early diagnosis of the respiratory distress syndrome (author's transl)]. 708 68

In an epidemiological study a random sample (1,554 males aged 35 to 54 years) of the population of a hydrogen chloride air-polluted area was investigated by means of the modified MRC questionnaire and maximal expiratory flow-volume curves. The MEF-values were dependent on age and height. We stated no significant differences between potash miners and the remaining population. In contrast we found significant differences between smokers and non-smokers and also between persons with and without respiratory symptoms. Persons with bronchitis and chronic bronchitis most differed from reference groups in MEF 75 (flow at high lung volume). Comparing smokers with non-smokers MEF 25 attained the highest significance level. In our investigation the maximal expiratory flow-volume curve was only a little more sensitive than conventional spirometry.
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PMID:[Relevance of the maximal expiratory flow-volume curve in an epidemiological study]. 714 32