Gene/Protein
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Enzyme
Compound
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Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0149514 (
bronchitis
)
6,902
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Clerodendrum
is a plant with potent antioxidant activity and has been frequently employed as a traditional remedy against
bronchitis
, asthma, liver and stomach disorders. Three species of genus
Clerodendrum
namely
Clerodendrum indicum, C. colebrookianum
and
C. inerme
(Syn.
Volkameria inermis
) were investigated for their possible activity against oxidative stress induced liver injury. Apart from generation of Reactive Oxygen Species (ROS) in the WRL-68 cell line (human hepatic cell line),
in-vitro
and
in-vivo
antioxidant assays were also assessed. Features of immune cell proliferation (MTT) were analyzed thoroughly. Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier Transform Infrared Spectroscopy (FTIR) analyses have been performed to identify the active biological compounds. These active biological compounds were further subjected to molecular docking. The antioxidant activity of three
Clerodendrum
sp. was significantly high in DPPH, nitric oxide, hydroxyl radical and hydrogen peroxide etc. Biochemical parameters like catalase, superoxide dismutase (SOD) and reduced glutathione (GSH) were generated in excess due to CCl
4
administration, which was ameliorated by treating with
Clerodendrum
extract. The phytochemical
24,25-Dihydroxyvitamin D
shows excellent binding affinity in Autodock Vina. The present study provided convincing evidences that
C. indicum
and
C. inerme
showed good result but
C. colebrookianum
performed better by almost all means.
...
PMID:The antioxidant rich active principles of
Clerodendrum
sp. controls haloalkane xenobiotic induced hepatic damage in murine model. 3176 23
