Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

127 cases of tracheal dyskinesia were seen in infants and children out of which 87 were 1 to 12 months of age. The diagnosis was based on the existence of a collapse reducing the tracheal diameter of more than 50% on endoscopy. Endoscopic examination was performed without general anesthesia. This material represents 5,8% of the patients submitted to this procedure. 85 patients had "primitive" dyskinesia and 42 had major associated abnormalities. Uni or bilateral bronchial dyskinesia was associated in 43% of the cases. The four commonest presenting symptoms were a stridulous or wheezing respiration, recurrent bronchitis, chronic cough, cyanosis. The frequency of associated digestive troubles: gastroesophageal reflux aspiration was noteworthy. Several functional consequences were encountered: hypoxemia, hypercapnia, abnormalities of FRC, increased RL, lowering of dynamic compliance, alterations of perfusion and ventilation on scintiscans. The prognosis was good in primitive cases. Two deaths occurred, in the group with associated abnormalities. The pattern of the patient with primitive dyskinesia and that of the patient with dyskinesia and associated abnormalities are outlined. Some features remarkable in this series of patients are pointed out in a discussion of the pathophysiology of the syndrome. Increased transmural pressure is not a common cause of tracheal dyskinesia and infection as well. The possibility of a temporary intrinsic anomaly of the tracheal wall is suggested. Even if its exact mechanism remains unknown, tracheal dyskinesia is a distinct entity observed in infants and children. It appears as a common cause of recurrent bronchopulmonary disease in the young.
 ...
PMID:[Tracheal dyskinesia (tracheomalacia) in infants and children. Study of 127 cases diagnosed through endoscopic examination (author's transl)]. 626 18

The main symptoms of bronchial asthma are expiratory wheezing, and overinflation of the lungs. In children the so-called obstructive bronchitis has to be considered especially since prognosis and therapy are different as compared with adult conditions. Clinically it is very important to differentiate between the severe asthmatic attack and status asthmaticus since the latter does not respond to bronchodilatation. The malign asthma crisis is of increasing importance. Chronic overinflation of the lungs seems to be a special risk factor. The classification of bronchial asthma according to frequency of attacks is meaningful especially in view of social-medical aspects.
 ...
PMID:[Clinical aspects of bronchial asthma in childhood]. 634 46

Methacholine sensitivity was evaluated in 166 young subjects who had normal resting spirometric values but who presented problems suggesting lower airways hyperreactivity. Fifty-eight patients (35%) did not have significant sensitivity. The diagnosis of asthma was excluded in this subgroup. Forty-one patients (25%) had mild methacholine sensitivity, 49 (30%) had moderate sensitivity, and 18 (11%) had extreme methacholine sensitivity. Many patients who reacted had chief complaints of cough, bronchitis, or other low respiratory-tract symptoms and did not complain of wheezing. Methacholine challenge helped to clarify appropriate therapy in these individuals. One-year follow-up of these patients showed most patients to be continuing the therapeutic regimen that had been prescribed initially. Methacholine bronchoprovocation was a useful adjunct to management of this large outpatient population of children and young adults and deserves attention as a procedure relevant to patients care, not solely as an investigational test.
 ...
PMID:Methacholine bronchial challenge in children. 680 93

The prevalence of asthma between birth and seven years was determined by questionnaire in 875 children as part of the Dunedin Multidisciplinary Child Development Study. From the combinations of asthma and/or wheezing reported in association with bronchitis, hayfever, eczema and allergies, a diagnosis of certain or probable asthma was made in 12.6 percent of these children. A further 22.6 percent admitted to wheezing, but a diagnosis of asthma could not be made with any certainty. Bronchitis was reported frequently, usually associated with wheezing. Children with more obvious asthma showed a male preponderance and significant differences in body build and school attendance compared with asymptomatic children.
 ...
PMID:Asthma in seven year old children: a report from the Dunedin Multidisciplinary Child Development Study. 695 68

The authors report the onset of wheezing and dyspnea in a 32-year-old, nonasthmatic male who was receiving propranolol for chronic migraine headaches of 20 years' duration. The symptoms first appeared during the "cold season"; the diagnosis was bronchitis. After three months without propranolol, the patient, prompted by continuing migraine headaches, again took the drug (40 mg bid). Within 48 hours he complained of rhinitis that rapidly progressed to wheezing, resembling bronchitis. Other reports in the literature are discussed.
 ...
PMID:Propranolol-induced dyspnea in a nonasthmatic male. 714 May 15

Viral diagnosis was performed using radioimmunoassay (RIA) for virus antigen in nasopharyngeal secretions (NPS) and complement-fixation (CF) tests of paired sera from specimens of 90 children hospitalized for acute respiratory infection. Major respiratory viruses sought for by both methods (adenoviruses, influenza A and B viruses, parainfluenza virus type 3, respiratory syncytial virus) were detected in 40 (44%) of the patients; 15% of the diagnoses were made by NPS-RIA alone. Serologic diagnosis of other viral infections was confirmed in six additional cases. In the different clinical entities a viral diagnosis was established as follows: pneumonia, 50%; upper or middle respiratory infection with no wheezing, 43%; acute laryngitis, 54%; and wheezing bronchitis, 29%. In each clinical entity the virus-positive and virus-negative patients had similar total leukocyte counts, mean C-reactive protein levels and mean erythrocyte sedimentation rates. There was no difference in the duration of hospitalization between the patients with positive and negative viral studies. It was not possible to divide the patients into clinical subgroups according to the presence or absence of detectable viral infection.
 ...
PMID:Clinical evaluation of radioimmunoassay of nasopharyngeal secretions and serology for diagnosis of viral infections in children hospitalized for respiratory infections. 716 28

Retrospective and prospective studies were done on children with wheezing bronchitis on the small Pacific island of Niue. Wheezing bronchitis was found to be a common cause of morbidity, but not mortality in these children. Episodes of the disease were most common in children under the age of 4 years and tended to disappear as they became older. A case-control study indicated smoking by the mother (P less than 0.0001), positive stool examination for parasites (P less than 0.001), mother with a history of wheezing bronchitis (P less than 0.01) and father smoking (P less than 0.05) were all correlated with wheezing bronchitis. Skin testing and serologic results indicated that hypersensitivity to house dust mite (Dermatophagoides pteronyssinus) and plantain (Plantago lanceolata) antigens were also associated with having wheezing bronchitis. This study demonstrates the multifactorial etiology of wheezing bronchitis on a Pacific island.
 ...
PMID:Wheezing bronchitis in children on a South Pacific Island. 721 69

This prospective 5-yr follow-up study of 1,241 textile workers from three mills was designed to determine the pattern and course of byssinosis in India and to distinguish this disease from chronic bronchitis. The initial prevalence of byssinosis was 14% in carding sections, 10% in spinning sections, and 11% in winding sections. In these dusty sections, the prevalences of both byssinosis and bronchitis increased with a longer service. Among workers with byssinosis; 56% had work-related and exertional dyspnea, 54% had chest tightness, 20% had wheezing, and 36% had cough. There was a history of Monday sickness in 22%. During follow-up it was confirmed that the atypical presentation of byssinosis with cough was more common in the carding department. The yearly decrease in pulmonary function was correlated with duration and degree of exposure to cotton dust. Thus, the decrease was larger in carding workers and in workers with byssinosis plus cough than in those with byssinosis or bronchitis. The yearly decrease in the one-second forced expiratory volume was different (p less than 0.05) for subjects with nonspecific chest symptoms (88 ml) and subjects with work-related chest symptoms (114 ml). The decreases in forced vital capacity and one-second forced expiratory volume were larger for increased dust loads. Fewer pulmonary infiltrates were seen in radiographs of workers with byssinosis than in those of workers with bronchitis. The immunoglobulins studied in 86 textiles workers and 17 control subjects showed higher IgG values among workers with work-related symptoms, especially cough, but not among those with bronchitic symptoms (p less than 0.01). Our results suggested that byssinosis is an entity distinct from chronic bronchitis.
 ...
PMID:Distinguishing byssinosis from chronic obstructive pulmonary disease. Results of a prospective five-year study of cotton mill workers in India. 725 17

The role of genetic or familial factors in the development of bronchopulmonary dysplasia (BPD) has not been evaluated. Detailed histories concerning asthma, allergy, and other lung diseases were obtained on first and second degree relatives of 17 infants with BPD, and 21 infants who had hyaline membrane disease but who did not develop BPD (HMD group). All infants in the BPD and HMD groups had hyaline membrane disease requiring assisted ventilation and greater than 50% inspired oxygen in the first five days of life. The diagnosis of HMD and BPD were made on radiographic and clinical criteria. Of the 17 infants with BPD, 13 had first or second degree relatives with physician-diagnosed asthma, compared to seven of 21 in the HMD group (P less than .01). In addition, a significantly greater number of relatives of BPD infants (P less than .005) had been hospitalized for their asthma as compared to HMD relatives. There were no differences between the groups for allergic rhinitis, eczema, bronchitis, emphysema, chronic cough, smoking, or wheezing with respiratory illnesses. These results suggest the possibility that airways with a genetic predisposition for reactivity may become highly reactive following neonatal lung disorders and their treatment. These irritable airways may then contribute to the development, or progression, or both of BPD.
 ...
PMID:Family history of asthma in infants with bronchopulmonary dysplasia. 737 38

We have examined the prevalence of incidence of asthma and other wheezing syndromes in subjects in a longitudinal epidemiologic study. The point prevalence of asthma was 6.6%, with the highest rates occurring in children. Rates were also relatively high in older subjects, in most of whom "chronic bronchitis and/or emphysema" had been concomitantly diagnosed. Other wheezing was very common in this population sample; in most age groups, the point prevalence rates of some form of wheezing exceeded 30%. New asthma developed in 1.4% of the subjects who were followed over a period of approximately 4 yr. New attacks of shortness of breath with wheeze occurred in 10.3% of the subjects at risk over the same time period. The incidence of asthma was greatest in young children, was least in late adolescence, and increased again in early adult life. The incidence was 1.5 times greater in young boys than in young girls but was much greater in women older than 40 yr of age, perhaps reflecting the diagnostic biases of physicians. In subjects younger than 40 yr of age, onset of the disease was strongly associated with previously demonstrated allergy skin test reactivity. New disease in this age group occurred de novo, primarily within the first few years of life or during early adult life. Subjects in whom asthma developed after 40 yr of age usually had prior symptoms of chronic bronchial irritation and often had obvious spirometric abnormalities. The disease in these subjects was not associated with positive allergy skin test reactions. Because in these older subjects it does not appear possible to clearly distinguish "asthma" from "chronic bronchitis," the label "asthmatic bronchitis" appears to be a reasonable descriptive term for this syndrome.
 ...
PMID:The prevalence and incidence of asthma and asthma-like symptoms in a general population sample. 743 22


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>