Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Parents of children with cystic fibrosis have been reported to have a high prevalence of increased airway reactivity, but these studies were done in a select young, healthy, symptomless population. In the present study respiratory symptoms were examined in 315 unselected parents of children with cystic fibrosis and 162 parents of children with congenital heart disease (controls). The cardinal symptom of airway reactivity, wheezing, was somewhat more prevalent in cystic fibrosis parents than in controls, but for most subgroups this increased prevalence did not reach statistical significance. Among those who had never smoked, 38% of obligate heterozygotes for cystic fibrosis but only 25% of the controls reported wheezing (p less than 0.05). The cystic fibrosis parents who had never smoked but reported wheezing had lower FEV1 and FEF25-75, expressed as a percentage of the predicted value, than control parents; and an appreciable portion of the variance in pulmonary function was contributed by the interaction of heterozygosity for cystic fibrosis with wheezing. For cystic fibrosis parents, but not controls, the complaint of wheezing significantly contributed to the prediction of pulmonary function (FEV1 and FEF25-75). In addition, parents of children with cystic fibrosis reported having lung disease before the age of 16 more than twice as frequently as control parents. Other respiratory complaints, including dyspnoea, cough, bronchitis, and hay fever, were as common in controls as in cystic fibrosis heterozygotes. These data are consistent with the hypothesis that heterozygosity for cystic fibrosis is associated with increased airway reactivity and its symptoms, and that the cystic fibrosis heterozygotes who manifest airway reactivity and its symptoms may be at risk for poor pulmonary function.
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PMID:Pulmonary abnormalities in obligate heterozygotes for cystic fibrosis. 343 35

A cross-sectional study to assess prevalence of respiratory abnormality was conducted among 107 South African foundry workers. The prevalence of pneumoconiosis was 10.3% overall, increasing to 38% for workers with more than 15 years of service. Dyspnea was present in 38% of workers, chronic simple bronchitis in 15.9%, and asthmatic symptoms in 27%. Pneumoconiosis was not associated with higher prevalence rates of other respiratory abnormalities. The high overall prevalence of respiratory symptoms might be explained by exposure to environmental pollutants other than dust.
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PMID:A respiratory epidemiological survey of workers in a small South African foundry. 349 78

An epidemic of nephritis occurred among soldiers in World War I, predominantly those in the trenches. Characterized by the sudden onset of albuminuria, hypertension, edema, and dyspnea, atypical features such as bronchitis, an evanescent course, low early mortality, and frequent relapses distinguished it from poststreptococcal glomerulonephritis. Pathologic features included glomerular ischemia, capillary thrombi, endocapillary proliferation, and frequently epithelial crescents, suggesting an underlying vasculitis. The cause was not established, but a postinfectious, possibly postviral, etiology seems most plausible. Trench nephritis was the major nephrologic problem of World War I, accounting for 5% of medical admissions and more than 10% of military hospital bed occupancy at that time.
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PMID:Trench nephritis: a retrospective perception. 351 20

A cross-sectional epidemiological study was carried out among 141 male subjects exposed to inorganic manganese (Mn) in a Mn oxide and salt producing plant (mean age 34.3 years; duration of exposure, mean 7.1 years, range 1-19 years). The results were compared with those of a matched control group of 104 subjects. The intensity of Mn exposure was moderate as reflected by the airborne Mn levels and the concentrations of Mn in blood (Mn-B) and in urine (Mn-U). A significantly higher prevalence of cough in cold season, dyspnea during exercise, and recent episodes of acute bronchitis was found in the Mn group. Lung ventilatory parameters (forced vital capacity, FVC; forced expiratory volume in one second, FEV1; peak expiratory flow rate, PEFR) were only mildly altered in the Mn group (smokers) and the intensity and the prevalence of these changes were not related to Mn-B, Mn-U, or duration of exposure. There was no synergistic effect between Mn exposure and smoking on the spirometric parameters. Except for a few nonspecific symptoms (fatigue, tinnitus, trembling of fingers, increased irritability), the prevalence of the other subjective complaints did not differ significantly between the control and Mn groups. Psychomotor tests were more sensitive than the standardized neurological examination for the early detection of adverse effects of Mn on the central nervous system (CNS). Significant alterations were found in simple reaction time (visual), audioverbal short-term memory capacity, and hand tremor (eye-hand coordination, hand steadiness). A slight increase in the number of circulating neutrophils and in the values of several serum parameters (ie, calcium, ceruloplasmin, copper, and ferritin) was also found in the Mn group. There were no clear-cut dose-response relationships between Mn-U or duration of Mn exposure and the prevalence of abnormal CNS or biological findings. The prevalences of disturbances in hand tremor and that of increased levels of serum calcium were related to Mn-B. The response to the eye-hand coordination test suggests the existence of a Mn-B threshold at about 1 microgram Mn/100 ml of whole blood. This study demonstrates that a time-weighted average exposure to airborne Mn dust (total dust) of about 1 mg/m3 for less than 20 years may present preclinical signs of intoxication.
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PMID:Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indices. 357 89

This study compared recalled physical and emotional sensations during episodes of acute dyspnea across pulmonary disease groups. The convenience sample consisted of 68 subjects with emphysema-bronchitis, asthma, vascular, and restrictive disease. Temporal patterns of physical and emotional sensations before and during episodes of dyspnea were identified. The frequency of sensations was remarkably similar across disease categories with few significant differences identified. Rather than the disease category, the frequency, intensity, and periodicity of the symptom of dyspnea had the greatest effect on the quality and frequency of sensations reported. The intensity of usual dyspnea reported on a visual analog scale varied significantly among groups, p = .026, with asthmatics having the lowest mean score and vascular subjects the highest. Females reported significantly greater usual dyspnea than males, p = .005. The variables of pulmonary disease group, gender, fatigue, and total network of social support were significantly related to usual dyspnea, and pulmonary group, gender, and attendance at Better Breathers classes were significantly related to worst dyspnea.
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PMID:The sensations of pulmonary dyspnea. 363 51

Curiously enough, a kind of curse combined with therapeutic fatalism still hovers over bronchial asthma and a sense of hopelessness may be encountered when faced with this illness. This pessimism is totally unfounded. However, our therapeutic possibilities depend partly on a better understanding of the asthma syndrome. In the past, this condition may not have been recognised for what it is, that is to say a multi factorial syndrome resulting from the innate and the acquired, from specific (allergic) and/or non-specific factors. Undoubtedly, too much responsibility has been placed on the allergic factor in asthma. Although important, it has made us overlook the fact that, allergic or not, asthma is an inflammatory illness of the bronchi provoked by the liberation of mediators. The role of histamine has been well known for a long time and we now realise the importance of the actions of the metabolites of arachidonic acid (prostaglandins and thromboxanes on the one hand, leukotrienes on the other). The characteristics bronchial hyperreactivity observed in asthma may certainly be congenital but this factor may also be acquired as in professional and post-viral asthma. If bronchial asthma remains under-diagnosed and under-treated in France and in Europe it is due to the fact that the artificial distinction between paroxysmal (bronchitis called "asthmatic"), and persistent (that is to say a so-called asthmatic illness), is is often maintained. There is no real ground for maintaining this distinction. Every child with wheezy dyspnea must therefore be the object of a thorough, initial medical examination, including in particular a respiratory function exploration followed by the institution of a long-term, coherent therapeutic strategy.
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PMID:[Present physiopathological concepts of asthma in adults]. 370 54

A rare case of arteriovenous fistula between an internal mammary artery and a pulmonary artery is presented. The clinical history of recurrent bronchitis and dyspnoea during exercise, the presence of right parasternal murmur with normal heart size and normal blood gases justified the execution of an arteriovenous thoracic angiography which revealed the presence of a cirsoid aneurysm supplied by the internal and external mammary arteries. Diagnostic investigation and surgical indication in patients with the rare fistulous communication between the internal mammary artery and the systemic or pulmonary circulation are analysed.
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PMID:Internal mammary artery to pulmonary artery fistula. 378 82

In a working population of 912 men, aged 22 to 54 years, 8.3% reported a history of childhood respiratory illness before 16 years of age. Those reporting a history of bronchitis or pneumonia (BP) before 2 years of age had significantly lower FEV1 values than those who did not report such a history, whereas those reporting BP at a later age, or primary tuberculosis, did not have lower values. The observed association was unlikely to be due to preferential recall bias, since BP before 2 years of age was not associated with a higher reported prevalence of current respiratory symptoms of cough, phlegm, or dyspnea, and the observed association remained after exclusion of those with a history of wheezing or asthma. Furthermore, the relation remained significant after taking into account parental smoking, Pi phenotype and a history of eczema in childhood. These results suggest that BP before 2 years of age, a period of rapid alveolar multiplication, may be related to the occurrence of adult chronic air-flow limitation.
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PMID:Relationships between functional measurements and childhood respiratory diseases according to the age of onset. 381 75

The authors consider that infants and young children with recurrent obstructive bronchitis require systematic follow-up care and treatment. To evaluate the severity of the disease, a rating scale was developed. Using this criteria, the severity of the disease in 132 infants and young children was evaluated. The patients were divided into a group of more severely ill and a group of less severely ill patients. The members of the more severely ill group were given long-term prophylactic treatment with ketotifen at a dose of 0.5 to 1.0 mg twice daily, in addition to standard symptomatic medication. Treatment with ketotifen afforded a decrease, although insignificant, in the number of coughing attacks, a significant decrease in the number of episodes of dyspnoea (p less than 0.025) and a significant decrease in the number of episodes of airway obstruction (p less than 0.0005). The authors conclude that patients with recurrent severe obstructive bronchitis should be given prophylactic treatment with ketotifen either during autumn and winter or throughout the year, depending on the severity of the symptoms.
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PMID:Wheezy bronchitis: results of treatment with ketotifen. 382 38

The results of changes in dyspnea and pulmonary function are reported in 27 emphysematous patients followed up for about 10 years after removal of giant bullae, which occupied at least 50% of a hemithorax. In 10 patients bilateral bullectomy was done. The spirographic improvement depends on the type of bulla. Resection of bullae at open communication with the bronchial tree resulted predominantly in improvement of forced expiratory volume as a percentage of vital capacity, whereas after closed bullae were resected, the increase in vital capacity was most apparent. Dyspnea lessened in all patients. Seven older patients died of ventilatory insufficiency. Preoperatively they were clinically and functionally severely disabled. They improved markedly after bullectomy, and their mean survival time was more than 7 years. In all 27 patients improvement of dyspnea and pulmonary function lasted several years and only gradually returned to preoperative values and beyond. No giant bullae recurred in the observation period; neither was there an accelerated progression of the emphysematous process. Our present selection criteria, based on previous experience, are as follows: giant bullae occupying at least 50% of a hemithorax, definite displacement of adjacent lung tissue, exclusion of the presence of vanishing lung syndrome, and absence of chronic purulent bronchitis.
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PMID:Bullectomy for giant bullae in emphysema. 394 61


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