Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several epidemiological studies have provided evidence that exposure to auto vehicular traffic increases the prevalence of bronchitis, cough and deficits in lung function and may exacerbate pre-existing asthma, especially in children. The aim of this study was to investigate the role of road traffic pollution on respiratory health in a large sample of Italian school children. Eighteen percent of the SIDRIA-2 sample reported high traffic density in the zone of residence; 60% and 20% of subjects reported a very frequent transit of cars and lorries, respectively on the street of residence. High frequency of lorry traffic in the street of residence was associated with significantly increased risks for chronic cough or phlegm and sinusitis symptoms. These results, confirming previous findings (SIDRIA, 1994-95), show that children living near streets with intense traffic of heavy vehicles are at higher risk for adverse respiratory effects, especially for productive cough.
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PMID:[Outdoor risk factors and adverse effects on respiratory health in childhood]. 1612 57

The causality of observed associations between air pollution and respiratory health in children is still subject to debate. If reduced air pollution exposure resulted in improved respiratory health of children, this would argue in favor of a causal relation. We investigated whether a rather moderate decline of air pollution levels in the 1990s in Switzerland was associated with a reduction in respiratory symptoms and diseases in school children. In nine Swiss communities, 9,591 children participated in cross-sectional health assessments between 1992 and 2001. Their parents completed identical questionnaires on health status and covariates. We assigned to each child an estimate of regional particles with an aerodynamic diameter < 10 microg/m3 (PM10) and determined change in PM10 since the first survey. Adjusted for socioeconomic, health-related, and indoor factors, declining PM10 was associated in logistic regression models with declining prevalence of chronic cough [odds ratio (OR) per 10-microg/m3 decline = 0.65, 95% confidence interval (CI), 0.54-0.79], bronchitis (OR = 0.66; 95% CI, 0.55-0.80), common cold (OR = 0.78; 95% CI, 0.68-0.89), nocturnal dry cough (OR = 0.70; 95% CI, 0.60-0.83), and conjunctivitis symptoms (OR = 0.81; 95% CI, 0.70-0.95). Changes in prevalence of sneezing during pollen season, asthma, and hay fever were not associated with the PM10 reduction. Our findings show that the reduction of air pollution exposures contributes to improved respiratory health in children. No threshold of adverse effects of PM10 was apparent because we observed the beneficial effects for relatively small changes of rather moderate air pollution levels. Current air pollution levels in Switzerland still exceed limit values of the Swiss Clean Air Act; thus, children's health can be improved further.
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PMID:Decline of ambient air pollution levels and improved respiratory health in Swiss children. 1626 23

Guidelines from the Global Initiative for Asthma (GINA) mention several medications for the treatment of asthma. These medications include oral and inhaled beta-2 agonists, oral and inhaled corticosteroids, xanthines, leukotriene receptor antagonists, and their combinations. In addition to asthma, these drugs are commonly prescribed to treat other respiratory diseases, such as acute bronchitis, chronic cough, lower respiratory infection, or even bronchopneumonia. We analyzed differences in prescribing patterns between pediatric patients with and those without asthma, as coded in the claim records from the National Health Insurance Research Database. Oral beta-2 agonists were the most frequently monotherapy in both groups of patients (52.6-77.6% vs 62.8-84. 8%). Oral beta-2 agonists combined with xanthines or oral corticosteroids combined with an oral beta-2 agonist were the most frequent combination therapies in both groups. Inhaled corticosteroids were used in 3.1-11.0% of patients with asthma; the rate varied by patient age. In conclusion, prescribing patterns were similar in pediatric patients with and those without asthma.
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PMID:Prescribing patterns of anti-asthma drugs in pediatric patients. 1638 35

Diseases of the airway are common and make up a significant proportion of the respiratory physician's workload. The major contributors to this situation, such as asthma, chronic obstructive pulmonary disease (COPD), and chronic cough, all result from airway inflammation and often have an overlapping clinical picture, which in some instances makes accurate clinical diagnosis difficult. Asthma is a condition characterized by variable airflow obstruction, airway hyper-responsiveness, and airway inflammation, which is usually eosinophilic. However, the relationship between eosinophilic inflammation and asthma is complex, with only a weak correlation between the severity of airway inflammation and the markers of the severity of asthma, such as Pc20 and FEV1. Eosinophilic bronchitis is characterized by a chronic cough and sputum eosinophilia without airway hyper-responsiveness or variable airflow obstruction. The asthma phenotype is characterized by microlocalization of mast cells in the airway smooth muscle, emphasizing the importance of airway smooth muscle dysfunction in asthma. COPD has generally been considered to be a neutrophilic disease, in contrast to asthma. However, there is increasing evidence that a significant subgroup exists consisting of patients with stable COPD who have chronic airway eosinophilia with a more steroid-responsive disease. This article covers the role of eosinophils in the airway disorders asthma, COPD, and eosinophilic bronchitis.
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PMID:Eosinophilic airway disorders. 1661 63

Cough is a normal protective mechanism which occurs many times every day. Cough with a viral infection lasts up to 2 weeks in 70-80% of children. Cough present for more than 4 weeks may be due to a recognized specific cause or non specific and considered protracted bronchitis. Chronic cough in children is different to that in adults and rarely due to GE reflux, postnasal drip or asthma. Treatment addresses the specific cause and symptomatic treatment is rarely needed or effective.
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PMID:Acute and chronic cough. 1679 99

Cough is the most common complaint that leads patients to seek medical attention. Especially chronic persistent cough is annoying, and requires appropriate diagnosis and treatment. Recent cough guidelines and original papers on cough epidemiology from various countries show remarkable differences in the aetiology of chronic cough among countries, especially between US, UK and Japan. Entities associated with rhinosinus disease (post-nasal drip/upper airway cough syndrome reported from the US, rhinitis or rhinosinusitis from the UK, and sinobronchial syndrome from Japan), and eosinophilic lower airway disorders (cough variant asthma, non-asthmatic eosinophilic bronchitis and atopic cough) are most confusing and might involve significant overlap. In this article, issues related to chronic cough aetiology are discussed, including geographic issues, e.g. 'simple' geography or difference in race, and difference in patient characteristics possibly arising from difference in the medical system.
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PMID:Geography and cough aetiology. 1716 94

Narcotic antitussives such as codeine reveal the antitussive effect primarily via the mu-opioid receptor in the central nervous system (CNS). The kappa-opioid receptor also seems to contribute partly to the production of the antitussive effect of the drugs. There is controversy as to whether delta-receptors are involved in promoting an antitussive effect. Peripheral opioid receptors seem to have certain limited roles. Although narcotic antitussives are the most potent antitussives at present, certain types of coughs, such as chronic cough, are particularly difficult to suppress even with codeine. In guinea pigs, coughs elicited by mechanical stimulation of the bifurcation of the trachea were not able to be suppressed by codeine. In gupigs with sub-acute bronchitis caused by SO2 gas exposure, coughing is difficult to inhibit with centrally acting antitussives such as codeine. Some studies suggest that neurokinins are involved in the development of codeine-resistant coughs. However, evidence supporting this claim is still insufficient. It is very important to characterize opiate-resistant coughs in experimental animals, and to determine which experimentally induced coughs correspond to which types of cough in humans. In this review, we describe the mechanisms of antitussive effects of narcotic antitussives, addressing codeine-sensitive and -resistant coughs, and including our own results.
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PMID:Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs. 1762 Jan 11

Asthma is one of the most common aetiologies of chronic cough. In a subgroup of asthmatics, cough may be the predominant or sole symptom. This condition is referred to as cough variant asthma (CVA). The diagnosis of CVA often presents a challenge since physical examination and spirometric tests may be normal. Up to 50% of patients with CVA have associated eosinophilic bronchitis, with the degree of eosinophilia being similar to that of other asthmatics. Demonstration of bronchial hyperresponsiveness by methacholine inhalation challenge, elevated level of exhaled nitric oxide and sputum eosinophilia support the presence of CVA, but the diagnosis is confirmed only upon resolution of the cough with specific antiinflammatory treatment.
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PMID:[Syndrom Corrao--cough variant asthma]. 1764 48

Cough is an important defensive reflex of the respiratory tract needed to clear and protect the upper airways; however, it may become exaggerated and interfere with quality of life. Although chronic cough may be successfully treated when associated with the common causes such as asthma and eosinophilic bronchitis, gastrooesophageal reflux disease and post-nasal drip syndrome or rhinosinusitis, increasingly, idiopathic cough or cough with no associated cause is recognised. Chronic cough is often associated with an increased response to tussive agents such as capsaicin, used as an index of the cough reflex. Some airway receptors mediate or influence cough through activation of vagal afferent pathways which converge on brain stem respiratory networks and of supramedullary centres. Plastic changes in intrinsic and synaptic excitability at the brain stem, spinal or ganglionic level may be the mechanism by which the cough reflex is enhanced in chronic cough. Subjective and objective measurements of cough in the clinic are now available but a major unmet need in chronic cough is the availability of effective antitussives. Future directions in chronic cough include the pathophysiological mechanisms of the enhanced cough reflex, and the discovery of effective antitussives that can successfully alleviate chronic cough.
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PMID:Chronic cough: future directions in chronic cough: mechanisms and antitussives. 1771 16

The respiratory effects of diphenylmethane diisocyanate (MDI)-based resins and ureaformol- and formophenolic-based resins, used in coal mining, are unknown. This cross-sectional study of 354 miners evaluated respiratory health in miners with MDI-related symptoms (IS) and ureaformol/formophenolic-related symptoms (UFS). The protocol included clinical examination, chest radiograph, questionnaire on respiratory symptoms, smoking habit, job history, resin handling, and spirometry. Resin handling concerned 27.7% of the miners. IS affected 5.6%, and 1.4% also after work. UFS affected 22.6%, and 2.3% also after work. Wheezing affected 35.6%; chronic cough, expectoration, or bronchitis about 10%; dyspnea 5.4%; and asthma 2.8%. The miners with UFS had significantly more frequent chronic cough, expectoration, chronic bronchitis, dyspnea, and wheezing, whereas those with IS at and after work had markedly lower FVC, FEV1, MMEF, FEF50%, and FEF25%. These findings raise the possibility of deleterious effects of exposures to MDI and ureaformol/formophenolic resins on respiratory health and lung function in coal miners during their working life.
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PMID:Associations of symptoms related to isocyanate, ureaformol, and formophenolic exposures with respiratory symptoms and lung function in coal miners. 1771 75


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