Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using precipitation method, low-density (LDL) and high-density (HDL2 and HDL3) lipoproteins were isolated from blood serum of human (donors, patients with ischemic heart) diseases--IHD, with bronchial asthma--BA, with chronic obstructive bronchitis--COB), of mammals predisposed (pig, rabbit) and resistant (rat, mink, Arctic fox) to atherosclerosis, of birds (hen, pigeon), of bony fish (trout, white-fish, pike-perch, pike, bream, burbot), and of cartilaginous fish (sturgeon, white sturgeon). From each lipoprotein group, lipids were extracted, separated by thin-layer chromatography, and analyzed quantitatively by the spectrophotometric method. In phosphatidylcholine and HDL2 cholesterol esters, bound fatty acids (FA) were determined by the method of gas-liquid chromatography. The main amount of total cholesterol has been established to be concentrated in human LDL, especially in the cases of IHD, and in LDL in mammals predisposed to atherosclerosis. In mammals resistant to atherosclerosis and in fish the almost entire cholesterol was revealed in HDL. The phospholipid content in HDL was lower in patients with pathologies and in mammals predisposed to atherosclerosis, while the highest content--in fish and mammals resistant to atherosclerosis. In homoiothermal animals and in human the main FA amount in HDL was represented by the omega6-series. Acids of the omega3-series amounted to a negligible percentage, especially in IHD. On the contrary, the HDL FA composition of poikilothermal animals (fish) had a very high content of polyunsaturated FA of the omega3-series. A conclusion is made that composition of lipid components in animal lipoproteins by the example of several studied species and of human has a non-stable character and is submitted to changes. Their most pronounced modifications with a negative trend took place in human LDL and HDL in IHD.
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PMID:[Content of the main lipid components in blood serum lipoproteins of human and of various animal species]. 1767 8

Lipid composition of blood serum and total lipids of low density lipoproteins (LDL) and high density lipoproteins (HDL2 and HDL3) were studied in human (donors, patients with ischemic heart disease, bronchial asthma, chronic obstructive bronchitis, as well as with a combined pathology), in mammals predisposed to atherosclerosis (pig, rabbit) and resistant to atherosclerosis (rat, mink, Arctic fox), in birds (hen, pigeon), in teleost fish (white fish, pikeperch, pike, bream, burbot) and cartilaginous fish (sturgeon, housen). It has been established that the most enriched in lipids is the blood serum of animals, particularly of cartilaginous fish. Twice lower is the lipid content in blood serum of donors than of animals. However, in the vascular, bronchial-pulmonary, and combined human pathologies the lipid level rises statistically significantly. In human and in animals predisposed to atherosclerosis the main mass of lipid is located in LDL, whereas in animals resistant to this disease--in HDL. The ratio of the human lipid content in LDL/HDL increases from 1.4 (in donors) to 2.7 in pathological states--in ischemic heart disease and its combination with chronic obstructive disease. In animals, a decrease of this ratio is noted from 1.0 to 0.2 in cartilaginous fish. By the example of one taxon (fish) there is established a regularity that indicates that evolution of lipoproteins occurred with an increase of the lipid amount in the "younger" LDL and with a decrease of concentration of the "colder" HDL.
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PMID:[Comparative biochemical analysis of blood serum lipoproteins from human and various animal species]. 1895 12