Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0149514 (bronchitis)
 6,902 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The alpha-1-antitrypsin values in bronchial secretion in fifty infants suffering from spastic bronchitis and/or bronchopneumonia were determined longitudinally. It was found that alpha-1-antitrypsin is regularly present in bronchial secretion. However, since alpha-1-antitrypsin was present only in the second sample of bronchial secretion in some investigated infants, it is necessary to determine it twice during the acute respiratory diseases at intervals of 3 days from appearance of the first clinical symptoms. Alpha-1-antitrypsin is present in bronchial secretion during the acute respiratory diseases in infants as long as physical finding exists on lungs. That points to the fact that this protein in bronchial secretion does not behave only as acute phase reactant but it represents a component of nonspezific defence mechanism of respiratory tract against infection. The alpha-1-antitrypsin determination in bronchial secretion in infants with acute respiratory diseases is of clinical importance since it can be used as the indicator for application of enzymatic secretolytics during these diseases.
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PMID:The values of alpha-1-antitrypsin in bronchial secretion in infants with spastic bronchitis and bronchopneumonia. 13 96

Corticosteroids caused a reduction in the ratio of sol-phase sputum concentration to serum concentration of albumin in 12 patients with chronic obstructive bronchitis, suggesting a reduction in protein transudation. Alpha-1-antitrypsin values followed the same pattern as those of albumin in both the control and treatment periods, confirming the similar behaviour of the two proteins. The alpha 1-antichymotrypsin ratios were on average three times higher than those of albumin in the control period, confirming the presence of local mechanisms in the lung for preferentially concentrating this protein. The sputum-to-serum ratio of alpha 1-antichymotrypsin, however, rose during steroid treatment with the result that there was a selective increase in this protease inhibitor, which may be of potential benefit to such patients.
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PMID:Effect of corticosteroids on sputum sol-phase protease inhibitors in chronic obstructive pulmonary disease. 698 37